Targeting mitochondrial 18 kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype

Abstract The aim of the present study was to establish mitochondrial cholesterol trafficking 18 kDa translocator protein (TSPO) as a potential therapeutic target, capable of increasing macrophage cholesterol efflux to (apo)lipoprotein acceptors. Expression and activity of TSPO in human (THP-1) macrophages were manipulated genetically and by the use of selective TSPO ligands

(E)-N′-(5-Bromo-2-methoxy­benzyl­idene)-4-chloro­benzohydrazide

The title Schiff base compound, C15H12BrClN2O2, crystallizes with two independent mol­ecules in the asymmetric unit. The mol­ecules adopt an E configuration with respect to the C=N double bond. The dihedral angles between the benzene rings are 24.4 (2) and 9.4 (2)° in the two mol­ecules. The crystal structure is stabilized by inter­molecular N—H⋯O hydrogen bonds, forming chains running along the b axis

{6-[(2-Anilinoeth­yl)imino­meth­yl]-2-eth­oxyphenolato}(thio­cyanato-κN)­copper(II)

In the title complex, [Cu(C17H19N2O2)(NCS)], the CuII atom is chelated by the phenolate O atom, the imine N atom and the amine N atom of the N,N′,O-tridentate 2-eth­oxy-6-[(2-anilino­ethyl)­iminometh­yl]phenolate ligand, and by the N atom of a thio­cyanate anion, forming a distorted CuON3 square-planar geometry. The dihedral angle between the aromatic rings of the ligand is 67.9 (4)°. In the crystal, inversion dimers linked by pairs of N—H⋯O hydrogen bonds occur, generating R 2 2(8) loops

Bis{2-[2-(isopropyl­ammonio)ethyl­imino­meth­yl]-5-methoxy­phenolato}copper(II) bis­(perchlorate)

In the title compound, [Cu(C13H20N2O2)2](ClO4)2, the CuII atom in the complex dication is chelated by two phenolate O atoms and two imine N atoms from two zwitterionic 2-[2-(isopropyl­ammonio)ethyl­imino­meth­yl]-5-methoxy­phenolate ligands, forming a distorted square-planar geometry. One of the perchlorate anions is disordered over two sites with occupancies of 0.611 (15) and 0.389 (15). Intra­molecular N—H⋯O hydrogen bonds are observed in the complex dication. In the crystal structure, the perchlorate anions are linked to complex dications by inter­molecular N—H⋯O hydrogen bonds