The White Cliff Edge of Dover

Media reports suggest that Michel Barnier has confidentially informed MEPs that Brexit talks are now “frozen”[1] and preparations on the continent for a no-deal Brexit are being accelerated. This is in stark contrast to official UK government documentation, which claims that “A scenario in which the UK leaves the EU without agreement (a ‘no deal’ scenario) remains unlikely given the mutual interests of the UK and the EU in securing a negotiated outcome”[2]

A spatial decomposition based math-heuristic approach to the asset protection problem

This paper addresses the highly critical task of planning asset protection activities during uncontrollable wildfires known in the literature as the Asset Protection Problem (APP). In the APP each asset requires a protective service to be performed by a set of emergency response vehicles within a specific time period defined by the spread of fire. We propose a new spatial decomposition based math-heuristic approach for the solution of large-scale APPs. The heuristic exploits the property that time windows are geographically correlated as fire spreads across a landscape. Thus an appropriate division of the landscape allows the problem to be decomposed into smaller more tractable sub-problems. The main challenge then is to minimise the difference between the final locations of vehicles from one division to the optimal starting locations of the next division. The performance of the proposed approach is tested on a set of benchmark instances from the literature and compared to the most recent Adaptive Large Neighborhood Search (ALNS) algorithm developed for the APP. The results show that our proposed solution approach outperforms the ALNS algorithm on all instances with comparable computation time. We also see a trend with the margin of out-performance becoming more significant as the problems become larger

A study of the effects of environmental and ablator performance uncertainties on heat shielding requirements for hyperbolic entry vehicles. Volume 2 - Summary of calculations

Calculated ablative quantities for nylon phenolic heat shielding materials of hyperbolic reentry vehicle

Data Analytics

This chapter sets out to illustrate the dictum that there is (almost) nothing new under the sun. More specifically, its goal is to make the unfamiliar familiar within the field of data analytics. The need for such a treatment can be gauged from the plethora of terms currently vying for attention in the contemporary data analysis landscape, which can be puzzling even for seasoned researchers. These terms include: data mining, data science, data analytics, machine learning, deep learning, neural networks, and artificial intelligence. Hybrid terms such as ‘big data analytics’ are also emerging. As for the current front-runner term, data analytics, the evidence provided by the number of search engine hits reveals multiple competing versions subdivided by application domains, ranging from business analytics and crime analytics, to performance analytics, visual analytics, and many more. There is also an emerging software sub-industry providing tools for data analytics, many of which are named after the company which originally developed them

Brexit? What the members of the Regional Studies Association think about Brexit

Drawing on findings from an international survey of RSA member’s attitudes towards Brexit, this insights articles explores what RSA members consider to be the likely impacts of Brexit on the economy and higher education sectors of the UK and EU

Tumor site immune markers associated with risk for subsequent basal cell carcinomas.

BackgroundBasal cell carcinoma (BCC) tumors are the most common skin cancer and are highly immunogenic.ObjectiveThe goal of this study was to assess how immune-cell related gene expression in an initial BCC tumor biopsy was related to the appearance of subsequent BCC tumors.Materials and methodsLevels of mRNA for CD3ε (a T-cell receptor marker), CD25 (the alpha chain of the interleukin (IL)-2 receptor expressed on activated T-cells and B-cells), CD68 (a marker for monocytes/macrophages), the cell surface glycoprotein intercellular adhesion molecule-1 (ICAM-1), the cytokine interferon-γ (IFN-γ) and the anti-inflammatory cytokine IL-10 were measured in BCC tumor biopsies from 138 patients using real-time PCR.ResultsThe median follow-up was 26.6 months, and 61% of subjects were free of new BCCs two years post-initial biopsy. Patients with low CD3ε CD25, CD68, and ICAM-1 mRNA levels had significantly shorter times before new tumors were detected (p = 0.03, p = 0.02, p = 0.003, and p = 0.08, respectively). Furthermore, older age diminished the association of mRNA levels with the appearance of subsequent tumors.ConclusionsOur results show that levels of CD3ε, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new BCC tumors

On-grid batteries for large-scale energy storage: Challenges and opportunities for policy and technology

ABSTRACT</jats:p

Pressure-induced amorphization and polyamorphism in one-dimensional single crystal TiO2 nanomaterials

The structural phase transitions of single crystal TiO2-B nanoribbons were investigated in-situ at high-pressure using the synchrotron X-ray diffraction and the Raman scattering. Our results have shown a pressure-induced amorphization (PIA) occurred in TiO2-B nanoribbons upon compression, resulting in a high density amorphous (HDA) form related to the baddeleyite structure. Upon decompression, the HDA form transforms to a low density amorphous (LDA) form while the samples still maintain their pristine nanoribbon shape. HRTEM imaging reveals that the LDA phase has an {\alpha}-PbO2 structure with short range order. We propose a homogeneous nucleation mechanism to explain the pressure-induced amorphous phase transitions in the TiO2-B nanoribbons. Our study demonstrates for the first time that PIA and polyamorphism occurred in the one-dimensional (1D) TiO2 nanomaterials and provides a new method for preparing 1D amorphous nanomaterials from crystalline nanomaterials.Comment: 4 figure