3,984 research outputs found
Identity studies: Multiple perspectives and implications for corporate-level marketing
Purpose – Provides a comprehensive review of the identity literature drawing on perspectives from marketing (corporate identity concept) and organisational behaviour (organisational identity) so as to provide an up-to –date overview of identity scholarship.
Findings – Reveals a growing congruency between scholars of marketing and organisational behaviour in their comprehension of identity. Identifies four principal schools of thought relating to identity which differ in terms of conceptualisation, locus of analysis and explanandum (corporate identity, visual identity, an organisation’s identity and organisational identity). Our review confirms the importance of identity especially in relation to the concepts underpinning the nascent field of corporate-level marketing.
Practical implications – the importance of taking a multidisciplinary perspective in the comprehension and management of identity in organisational contexts.
Originality/Value – The first major review of identity studies that synthesises the marketing and organisational behaviour approaches to identity. Offers pointers in terms of the research agenda to be followed
Structural Simplification of Bedaquiline: the Discovery of 3-(4-(N,N-dimethylaminomethyl)phenyl)quinoline Derived Antitubercular Lead Compounds
Bedaquiline (BDQ) is a novel and highly potent last-line antituberculosis drug that was approved by the US FDA in 2013. Owing to its stereo-structural complexity, chemical synthesis and compound optimization are rather difficult and expensive. This study describes the structural simplification of bedaquiline while preserving antitubercular activity. The compound's structure was split into fragments and reassembled in various combinations while replacing the two chiral carbon atoms with an achiral linkage instead. Four series of analogues were designed; these candidates retained their potent antitubercular activity at sub-microgram per mL concentrations against both sensitive and multidrug-resistant (MDR) Mycobacterium tuberculosis strains. Six out of the top nine MIC-ranked candidates were found to inhibit mycobacterial ATP synthesis activity with IC50 values between 20 and 40 μm, one had IC50>66 μm, and two showed no inhibition, despite their antitubercular activity. These results provide a basis for the development of chemically less complex, lower-cost bedaquiline derivatives and describe the identification of two derivatives with antitubercular activity against non-ATP synthase related targets
On the Calibration of a Size-Structured Population Model from Experimental Data
The aim of this work is twofold. First, we survey the techniques developed in
(Perthame, Zubelli, 2007) and (Doumic, Perthame, Zubelli, 2008) to reconstruct
the division (birth) rate from the cell volume distribution data in certain
structured population models. Secondly, we implement such techniques on
experimental cell volume distributions available in the literature so as to
validate the theoretical and numerical results. As a proof of concept, we use
the data reported in the classical work of Kubitschek [3] concerning
Escherichia coli in vitro experiments measured by means of a Coulter
transducer-multichannel analyzer system (Coulter Electronics, Inc., Hialeah,
Fla, USA.) Despite the rather old measurement technology, the reconstructed
division rates still display potentially useful biological features
Non-intubated uniportal anatomical lung resection: a propensity score matched analysis shows faster recovery is possible even in the early experience
OBJECTIVES: Non-intubated uniportal video-assisted thoracoscopic surgery (VATS) has gained considerable interest for major lung resections in recent years. However, characteristics of the learning curve and whether benefits can be shown in the early experience of adapting this technique have hitherto not been investigated ...postprin
Terahertz quantum cascade laser as local oscillator in a heterodyne receiver
Terahertz quantum cascade lasers have been investigated with respect to their performance as a local oscillator in a heterodyne receiver. The beam profile has been measured and transformed in to a close to Gaussian profile resulting in a good matching between the field patterns of the quantum cascade laser and the antenna of a superconducting hot electron bolometric mixer. Noise temperature measurements with the hot electron bolometer and a 2.5 THz quantum cascade laser yielded the same result as with a gas laser as local oscillator. (C) 2005 Optical Society of America
Composition of gut microbiota in infants in China and global comparison
published_or_final_versio
A hysteretic multiscale formulation for nonlinear dynamic analysis of composite materials
This article has been made available through the Brunel Open Access Publishing Fund.A new multiscale finite element formulation
is presented for nonlinear dynamic analysis of heterogeneous
structures. The proposed multiscale approach utilizes
the hysteretic finite element method to model the microstructure.
Using the proposed computational scheme, the micro-basis functions, that are used to map the microdisplacement components to the coarse mesh, are only evaluated once and remain constant throughout the analysis procedure. This is accomplished by treating inelasticity at the micro-elemental level through properly defined hysteretic evolution equations. Two types of imposed boundary conditions are considered for the derivation of the multiscale basis functions, namely the linear and periodic boundary conditions. The validity of the proposed formulation as well as its computational efficiency are verified through illustrative numerical experiments
HiNO: An Approach for Inferring Hierarchical Organization from Regulatory Networks
BACKGROUND: Gene expression as governed by the interplay of the components of regulatory networks is indeed one of the most complex fundamental processes in biological systems. Although several methods have been published to unravel the hierarchical structure of regulatory networks, weaknesses such as the incorrect or inconsistent assignment of elements to their hierarchical levels, the incapability to cope with cyclic dependencies within the networks or the need for a manual curation to retrieve non-overlapping levels remain unsolved. METHODOLOGY/RESULTS: We developed HiNO as a significant improvement of the so-called breadth-first-search (BFS) method. While BFS is capable of determining the overall hierarchical structures from gene regulatory networks, it especially has problems solving feed-forward type of loops leading to conflicts within the level assignments. We resolved these problems by adding a recursive correction approach consisting of two steps. First each vertex is placed on the lowest level that this vertex and its regulating vertices are assigned to (downgrade procedure). Second, vertices are assigned to the next higher level (upgrade procedure) if they have successors with the same level assignment and have themselves no regulators. We evaluated HiNO by comparing it with the BFS method by applying them to the regulatory networks from Saccharomyces cerevisiae and Escherichia coli, respectively. The comparison shows clearly how conflicts in level assignment are resolved in HiNO in order to produce correct hierarchical structures even on the local levels in an automated fashion. CONCLUSIONS: We showed that the resolution of conflicting assignments clearly improves the BFS-method. While we restricted our analysis to gene regulatory networks, our approach is suitable to deal with any directed hierarchical networks structure such as the interaction of microRNAs or the action of non-coding RNAs in general. Furthermore we provide a user-friendly web-interface for HiNO that enables the extraction of the hierarchical structure of any directed regulatory network. AVAILABILITY: HiNO is freely accessible at http://mips.helmholtz-muenchen.de/hino/
Towards Real-Time Head Pose Estimation: Exploring Parameter-Reduced Residual Networks on In-the-wild Datasets
Head poses are a key component of human bodily communication and thus a
decisive element of human-computer interaction. Real-time head pose estimation
is crucial in the context of human-robot interaction or driver assistance
systems. The most promising approaches for head pose estimation are based on
Convolutional Neural Networks (CNNs). However, CNN models are often too complex
to achieve real-time performance. To face this challenge, we explore a popular
subgroup of CNNs, the Residual Networks (ResNets) and modify them in order to
reduce their number of parameters. The ResNets are modifed for different image
sizes including low-resolution images and combined with a varying number of
layers. They are trained on in-the-wild datasets to ensure real-world
applicability. As a result, we demonstrate that the performance of the ResNets
can be maintained while reducing the number of parameters. The modified ResNets
achieve state-of-the-art accuracy and provide fast inference for real-time
applicability.Comment: 32nd International Conference on Industrial, Engineering & Other
Applications of Applied Intelligent Systems (IEA/AIE 2019
Narrow band imaging-assisted transurethral resection for non-muscle invasive bladder cancer significantly reduces residual tumour rate
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