Commentary on using the SF-36 or MOS-HIV in studies of persons with HIV disease

The purpose was to compare and comment on use of the SF-36 and MOS-HIV instruments in studies of persons with HIV disease. Three medical information databases were searched to identify examples of HIV studies that included the MOS-HIV or SF-36. Thirty-nine and 14 published articles were identified for illustration in comparing the use of the MOS-HIV and SF-36 in HIV disease, respectively. Support for the reliability and construct validity of the MOS-HIV and SF-36 was found. Ceiling and floor effects were reported for both the MOS-HIV and SF-36; however, ceiling effects were more common for the MOS-HIV, in part due to fewer items in the physical, social, and role functioning domains. The MOS-HIV measures three domains hypothesized to be associated with the health deterioration of HIV disease not measured by the SF-36; however, these domains may not assess aspects of HIV disease that typify the majority of the persons with HIV disease today. National norms for the U.S. adult population (and other nations) are available for the SF-36. In addition, the SF-36 has been used in a wide variety of patient populations, enabling comparisons of HIV-infected persons with persons with other health conditions. No national norms for the MOS-HIV are available. We conclude that there is currently insufficient evidence in the literature to recommend the use of the MOS-HIV over the SF-36 in HIV-infected persons. Although the SF-36 is not targeted at HIV, it may be preferable to use the SF-36 over the MOS-HIV due to fewer ceiling effects, availability of national norms, and the vast amount of data for other populations in the U.S. and around the world. Head-to-head comparisons demonstrating the unique value of the MOS-HIV over the SF-36 are clearly needed. More importantly, additional work needs to be directed at comparing the MOS-HIV and other putatively HIV-targeted instruments to one another to help demarcate aspects of HRQOL that are truly generic versus specific to HIV disease. Using both a generic and targeted HRQOL measure is a good general strategy, but this has not been a typical practice in studies of HIV because the MOS-HIV is so similar in content to the SF-36

Concert recording 2018-03-02

[Track 1]. Quartet in A major, TWV 43:A1. Soave ; Allegro ; Andante ; Vivace / Georg Phillip Telemann -- [Track 2]. Du bist verflucht, o Shreckensstimmel, TWV 1:385. Aria: Du bist verflucht o Shreckensstimme ; Recitative: So ist\u27s: Seitdem bei Edens Baum des Baum des ersten Menschen erste Sunde ; Aria: Frohlocket, ihr seligen Kinder der Freien! / Telemann -- [Track 3]. Seele, lernce dich erkennen, TWV 1:1258. Aria: Seele, lerne dich erkennen! ; Recitative: Ein Vogelchen, dem noch die Glieder ; Aria: So will ich dich mit Freuden kussen / Telemann -- [Track 4]. Sonatae unarum fidium: Sonata no. 4 in D major. Ciaccona ; Variatio ; Sarabande ; Gigue ; Adagio e recitativo ; Allegro / Johann Heinrich Schmelzer -- [Track 5]. Auf ehernen Mauern, TWV 1:96. Aria; Auf ehernen Mauern, auf marmornen Grunden ; Recitative: So lange noch der Unbestand den Schuchternen ; Aria: Ja, ja, wiederholt nur eure Tucke? / Telemann -- [Track 6]. Nouveaux Quatuors: Quartet no. 6 in E minor, TWV 43:34. Prelude; tres vite ; Gay ; Vite ; Gracieusement ; Distrait ; Modere / Telemann

Mixed-Methods Analysis of Supports and Barriers for Rural College Students

This article outlines an exploratory sequential mixed-methods study on the environmental supports and barriers for students attending a rural college. Data collected through six focus group interviews (N = 19) indicated 20 themes associated with student success; faculty practices with students; administrative issues; or president, cabinet, and board of trustee vision. An 86-item survey, grounded in qualitative themes, yielded evidence of convergence and divergence for an initial sample of 256 students

Childcare, choice and social class: Caring for young children in the UK

This paper draws on the results of two qualitative research projects examining parental engagements with the childcare market in the UK. Both projects are located in the same two London localities. One project focuses on professional middle class parents, and the other on working class families, and we discuss the key importance of social class in shaping parents' differential engagement with the childcare market, and their understandings of the role childcare plays in their children's lives. We identify and discuss the different "circuits" of care (Ball et al 1995) available to and used by families living physically close to each other, but in social class terms living in different worlds. We also consider parents' relationships with carers, and their social networks. We conclude that in order to fully understand childcare policies and practices and families' experiences of care, an analysis which encompasses social class and the workings of the childcare market is needed

Assessing the Prevalence of Gendered Ageism Among Long-Term Care Employees

Ageism, discrimination based on age, particularly against older adults, intersects with other forms of discrimination, including sexism. In long-term care settings, gendered ageism can manifest in various ways, influencing both the quality and type of care older adults receive based on their gender. Understanding and addressing ageism in these settings is essential to ensuring the dignity, respect, and quality of life for older adults. The purpose of this mixed methods study was to explore long-term care (LTC) employees’ attitudes towards age and gender. A theoretical framework of feminist disability theory and compulsory youthfulness allows for an intersectional critique of ageism, sexism, and ableism and how each contributes to the oppression of long-living adults (age 80 and over) and disabled long-living adults. Triangulation of data was achieved through surveys, interviews, and artifacts. Sixty employees completed an on-line survey consisting of demographic questions (age, race, gender, years employed in LTC, highest level of education, employment) and the Fraboni Scale of Ageism during the Coronavirus pandemic between August 21, 2020 and September 22, 2020. Data were analyzed using an independent samples t-test, One Way ANOVA, and One Sample Median Test. Twenty-one of these employees also participated in a phone interview during the time period of survey collection. Interview data were analyzed using open coding, axial coding, then thematic analysis. Cultural artifacts available to the primary researcher, and relating to the study, were noted. Considering the primary researcher was not allowed to enter the facility, the types of artifacts collected included social media posts via Twitter, Facebook, and the organization’s blog. Blog and social media posts ranged from September 1, 2020 to February 1, 2021. Mixing of qualitative and quantitative data was completed for the final results by merging them via side by side comparison table. Quantitative findings indicated there was a statistical difference in FSA scores for younger adults (M = 49.33, SD = 6.08), adults (M = 52.97, SD = 8.66), and older adults (M = 46.76, SD = 7.85). Middle age adults had significantly higher FSA scores than younger adults and older adults. Qualitative data provided the strongest connection that sexist and ageist attitudes exist among employees as it demonstrated that some employees had different expectations of residents based on the residents’ gender. A review of social media and policy artifacts concluded there was no resident perspective present in research topics, research trials, blog posts, or community events. Overall, findings indicated employees’ interactions with, and attitudes towards, residents were influenced by themes of compassionate ageism, ableism, and identity, which resulted in meta-theme caregiver validation and reward. Although most employees felt a deep connection with residents, they detached themselves from the aging process, instead seeking affirmation and recognition from residents through gratitude and positive interactions. Results from this study indicated certain power dynamics and suggested that employees actively sought positive care interactions with residents. Most employees preferred to care for residents who appeared to need assistance, were appreciative, and interacted with the employee in a positive way. When this occurred, employees enjoyed relationships with these residents and caring for them on a continuous basis. Essentially, employees preferred to care for someone who conformed to that employee’s expectations for care

Cytoplasmic dynein nomenclature

A variety of names has been used in the literature for the subunits of cytoplasmic dynein complexes. Thus, there is a strong need for a more definitive consensus statement on nomenclature. This is especially important for mammalian cytoplasmic dyneins, many subunits of which are encoded by multiple genes. We propose names for the mammalian cytoplasmic dynein subunit genes and proteins that reflect the phylogenetic relationships of the genes and the published studies clarifying the functions of the polypeptides. This nomenclature recognizes the two distinct cytoplasmic dynein complexes and has the flexibility to accommodate the discovery of new subunits and isoforms

Coupling high-frequency stream metabolism and nutrient monitoring to explore biogeochemical controls on downstream nitrate delivery

Instream biogeochemical process measurements are often short-term and localized. Here we use in situ sensors to quantify the net effects of biogeochemical processes on seasonal patterns in baseflow nitrate retention at the river-reach scale. Dual-station high-frequency in situ nitrate measurements, were coupled with high-frequency measurements of stream metabolism and dissolved inorganic carbon, in a tributary of the Buffalo National River, Arkansas. Nitrate assimilation was calculated from net primary production, and combined with mass-balance measurements, to estimate net nitrification and denitrification. The combined net effects of these instream processes (assimilation, denitrification, and nitrification) removed >30–90% of the baseflow nitrate load along a 6.5 km reach. Assimilation of nitrate by photoautotrophs during spring and early summer was buffered by net nitrification. Net nitrification peaked during the spring. After midsummer, there was a pronounced switch from assimilatory nitrate uptake to denitrification. There was clear synchronicity between the switch from nitrate assimilation to denitrification, a reduction in river baseflows, and a shift in stream metabolism from autotrophy to heterotrophy. The results show how instream nitrate retention and downstream delivery is driven by seasonal shifts in metabolic pathways; and how continuous in situ stream sensor networks offer new opportunities for quantifying the role of stream biota in the dynamics, fate, and transport of nitrogen in fluvial systems

Twelve‐hour tides in the winter northern polar mesosphere and lower thermosphere

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94767/1/jgra16221.pd

The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure