39 research outputs found
Comparing Apples with Apples: Robust Detection Limits for Exoplanet High-Contrast Imaging in the Presence of non-Gaussian Noise
Over the past decade, hundreds of nights have been spent on the worlds
largest telescopes to search for and directly detect new exoplanets using
high-contrast imaging (HCI). Thereby, two scientific goals are of central
interest: First, to study the characteristics of the underlying planet
population and distinguish between different planet formation and evolution
theories. Second, to find and characterize planets in our immediate Solar
neighborhood. Both goals heavily rely on the metric used to quantify planet
detections and non-detections.
Current standards often rely on several explicit or implicit assumptions
about the noise. For example, it is often assumed that the residual noise after
data post-processing is Gaussian. While being an inseparable part of the
metric, these assumptions are rarely verified. This is problematic as any
violation of these assumptions can lead to systematic biases. This makes it
hard, if not impossible, to compare results across datasets or instruments with
different noise characteristics.
We revisit the fundamental question of how to quantify detection limits in
HCI. We focus our analysis on the error budget resulting from violated
assumptions. To this end, we propose a new metric based on bootstrapping that
generalizes current standards to non-Gaussian noise. We apply our method to
archival HCI data from the NACO-VLT instrument and derive detection limits for
different types of noise. Our analysis shows that current standards tend to
give detection limit that are about one magnitude too optimistic in the
speckle-dominated regime. That is, HCI surveys may have excluded planets that
can still exist.Comment: After first iteration with the referee, resubmitted to AJ. Comments
welcome
CROCODILE \\ Incorporating medium-resolution spectroscopy of close-in directly imaged exoplanets into atmospheric retrievals via cross-correlation
The investigation of the atmospheres of closely separated, directly imaged
gas giant exoplanets is challenging due to the presence of stellar speckles
that pollute their spectrum. To remedy this, the analysis of medium- to
high-resolution spectroscopic data via cross-correlation with spectral
templates (cross-correlation spectroscopy) is emerging as a leading technique.
We aim to define a robust Bayesian framework combining, for the first time,
three widespread direct-imaging techniques, namely photometry, low-resolution
spectroscopy, and medium-resolution cross-correlation spectroscopy in order to
derive the atmospheric properties of close-in directly imaged exoplanets. Our
framework CROCODILE (cross-correlation retrievals of directly imaged
self-luminous exoplanets) naturally combines the three techniques by adopting
adequate likelihood functions. To validate our routine, we simulated
observations of gas giants similar to the well-studied ~Pictoris~b
planet and we explored the parameter space of their atmospheres to search for
potential biases. We obtain more accurate measurements of atmospheric
properties when combining photometry, low- and medium-resolution spectroscopy
into atmospheric retrievals than when using the techniques separately as is
usually done in the literature. We find that medium-resolution () K-band cross-correlation spectroscopy alone is not suitable to constrain
the atmospheric properties of our synthetic datasets; however, this problem
disappears when simultaneously fitting photometry and low-resolution () spectroscopy between the Y and M bands. Our framework allows the
atmospheric characterisation of directly imaged exoplanets using the
high-quality spectral data that will be provided by the new generation of
instruments such as VLT/ERIS, JWST/MIRI, and ELT/METIS
Predictors of Venous Thromboembolic Events Associated with Central Venous Port Insertion in Cancer Patients
Insertion of central venous port (CVP) catheter in the cancer population is associated with increased incidence of venous thromboembolic events (VTE). However, trials have shown limited benefit of antithrombotic treatment to prevent catheter-related venous thrombosis. This prospective observational cohort study was designed to assess the incidence of VTE closely related to CVP implantation in patients with cancer and undergoing chemotherapy, and to identify a high risk subgroup of patients. Between February 2006 and December 2011, 1097 consecutive cancer patients with first CVP implantation were included. Catheter-related VTE were defined as deep venous thrombosis in the arm, with or without pulmonary embolism (PE), or isolated PE. The incidence of CVP-associated VTE was 5.9% (IC95 4.4â7.3%) at 3 months, and 11.3% (IC95 9.4â13.2%) at 12 months. The incidence of any VTE was 7.6% (IC95 6.0â9.3%) at 3 months, and 15.3% (IC95 13.1â17.6%) at 12 months. High Khorana risk score and lung cancer were significant predictors of 3 month VTE. In conclusion, this large cohort study of patients with first CVP catheter implantation confirms the high incidence of VTE associated with the CVP implantation and allow identifying high risk patients who may benefit from thromboprophylaxis
Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000â14 (CONCORD-3) : analysis of individual data from 258 cancer registries in 61 countries
Background Leukaemias comprise a heterogenous group of haematological malignancies. In CONCORD-3, we analysed
data for children (aged 0â14 years) and adults (aged 15â99 years) diagnosed with a haematological malignancy
during 2000â14 in 61 countries. Here, we aimed to examine worldwide trends in survival from leukaemia, by age and
morphology, in young patients (aged 0â24 years).
Methods We analysed data from 258 population-based cancer registries in 61 countries participating in CONCORD-3
that submitted data on patients diagnosed with leukaemia. We grouped patients by age as children (0â14 years),
adolescents (15â19 years), and young adults (20â24 years). We categorised leukaemia subtypes according to the
International Classification of Childhood Cancer (ICCC-3), updated with International Classification of Diseases
for Oncology, third edition (ICD-O-3) codes. We estimated 5-year net survival by age and morphology, with 95% CIs,
using the non-parametric Pohar-Perme estimator. To control for background mortality, we used life tables by
country or region, single year of age, single calendar year and sex, and, where possible, by race or ethnicity. All-age
survival estimates were standardised to the marginal distribution of young people with leukaemia included in the
analysis.
Findings 164563 young people were included in this analysis: 121328 (73·7%) children, 22963 (14·0%) adolescents, and
20272 (12·3%) young adults. In 2010â14, the most common subtypes were lymphoid leukaemia (28205 [68·2%] patients)
and acute myeloid leukaemia (7863 [19·0%] patients). Age-standardised 5-year net survival in children, adolescents, and
young adults for all leukaemias combined during 2010â14 varied widely, ranging from 46% in Mexico to more than
85% in Canada, Cyprus, Belgium, Denmark, Finland, and Australia. Individuals with lymphoid leukaemia had better
age-standardised survival (from 43% in Ecuador to â„80% in parts of Europe, North America, Oceania, and Asia) than
those with acute myeloid leukaemia (from 32% in Peru to â„70% in most high-income countries in Europe,
North America, and Oceania). Throughout 2000â14, survival from all leukaemias combined remained consistently
higher for children than adolescents and young adults, and minimal improvement was seen for adolescents and young
adults in most countries.
Interpretation This study offers the first worldwide picture of population-based survival from leukaemia in children,
adolescents, and young adults. Adolescents and young adults diagnosed with leukaemia continue to have lower
survival than children. Trends in survival from leukaemia for adolescents and young adults are important indicators
of the quality of cancer management in this age group.peer-reviewe
Documents relatifs aux missions "volantes" dirigées en Valais par le P. Honoré de Chambéry, capucin, (1649-1651)
Human-Avatar Interaction in Virtual Environment to Assess and Train Sensorimotor: Application to the Slap Shot in Hockey
International audienceHere we present the conception, implementation and application of a virtual environment simulator dedicated to the assessment and training of slap shot performance in hockey. The simulator is based on human-avatar interaction, namely a real shooter and a virtual goalkeeper whose behavior is dependent on that of the shooter. The synthesis of the virtual goalkeeper relied on a high-quality model and realistic, motion-captured movements. A regression model based on Kriging was used to predict in real-time the shooter's behavior in order to trigger the blocking moves of the virtual goalkeeper at the right time. Our model provided accurate predicted values as well as an estimation of the reliability of these values, which allowed us to optimize the behavioral animation of the virtual goalkeeper. We then ran a validation experiment testing the effectiveness of our simulator. The simulator proved very useful both to assess the initial performance of the players and to train and improve this performance. In particular, training as little as 3 hours with our simulator gave rise to substantial and significant improvements (up to 22 percent) of the redirection threshold, i.e., the minimum time required to successfully redirect a shot during movement execution when the outcome is imperiled. Importantly, in comparison with âclassicalâ training methods, our simulator better triggers (precisely and timely) the movements of the goalkeeper based on the movements of the shooter
Diketopyrrolopyrrole oligomers and compositions, comprising diketopyrrolopyrrole oligomers
info:eu-repo/semantics/publishe