The response of the Western Equatorial Pacific ocean to Westerly wind bursts during november 1989 to january 1990

Several 5 to 10 m s-1 westerly wind bursts of 10-15 days' duration occurred in the Western Equatorial Pacific during november 1989 to January 1990. The response to these wind bursts was characterized by a 400- to 600 km wide eastward jet in the upper 100-150 m along the equator between 135°E and the date line. Flow in this jet accelarated to speeds of over 100 cm s-1 within 1 week after the onset of westerly winds in november 1989 in association with super thyphoon Irma. In addition, a 20 to 40 cm s-1 westward counterflow developed between 2°N and 2°S below the surface jet separating it from the eastward flow of the Equatorial undercurrent in the thermocline. Changes in surface layer zonal volume transport in the Western Pacific due to westerly wind bursts were 25-56 Sv based on comparison of three shipboard velocity transects in november and december 1989. Although fluctuations in current speeds in the thermocline were generally smaller and less directly related to local wind forcing than those in the surface layer, the Equatorial undercurrent decelerated to less than 20 cm s-1 (i.e., less than half its speed before the onset of westerlies) by early december 1989. (D'après résumé d'auteur

High-temperature deformation behavior of a gamma TiAl alloy-microstructural evolution and mechanisms

The present investigation was carried out in the context of the internal-variable theory of inelastic deformation and the dynamic-materials model (DMM), to shed light on the high-temperature deformation mechanisms in TiAl. A series of load-relaxation tests and tensile tests were conducted on a fine-grained duplex gamma TiAl alloy at temperatures ranging from 800 degreesC to 1050 degreesC. Results of the load-relaxation tests, in which the deformation took place at an infinitesimal level (epsilon congruent to 0.05), showed that the deformation behavior of the alloy was well described by the sum of dislocation-glide and dislocation-climb processes. To investigate the deformation behavior of the fine-grained duplex gamma TiAl alloy at a finite strain level, processing maps were constructed on the basis of a DMM. For this purpose, compression tests were carried out at temperatures ranging from 800 degreesC to 1250 degreesC using strain rates ranging from 10 to 10(-4)/s. Two domains were identified and characterized in the processing maps obtained at finite strain levels (0.2 and 0.6). One domain was found in the region of 980 degreesC and 10(-3)/s with a peak efficiency (maximum efficiency of power dissipation) of 48 pct and was identified as a domain of dynamic recrystallization (DRx) from microstructural observations. Another domain with a peak efficiency of 64 pct was located in the region of 1250 degreesC and 10(-4)/s and was considered to be a domain of superplasticity.ope

Developing an instrument to assess the endoscopic severity of ulcerative colitis : The Ulcerative Colitis Endoscopic Index of Severity (UCEIS)

Full list of Investigators is given at the end of the article.Background: Variability in endoscopic assessment necessitates rigorous investigation of descriptors for scoring severity of ulcerative colitis (UC). Objective: To evaluate variation in the overall endoscopic assessment of severity, the intra- and interindividual variation of descriptive terms and to create an Ulcerative Colitis Endoscopic Index of Severity which could be validated. Design: A two-phase study used a library of 670 video sigmoidoscopies from patients with Mayo Clinic scores 0-11, supplemented by 10 videos from five people without UC and five hospitalised patients with acute severe UC. In phase 1, each of 10 investigators viewed 16/24 videos to assess agreement on the Baron score with a central reader and agreed definitions of 10 endoscopic descriptors. In phase 2, each of 30 different investigators rated 25/60 different videos for the descriptors and assessed overall severity on a 0-100 visual analogue scale. κ Statistics tested inter- and intraobserver variability for each descriptor. A general linear mixed regression model based on logit link and β distribution of variance was used to predict overall endoscopic severity from descriptors. Results: There was 76% agreement for 'severe', but 27% agreement for 'normal' appearances between phase I investigators and the central reader. In phase 2, weighted κ values ranged from 0.34 to 0.65 and 0.30 to 0.45 within and between observers for the 10 descriptors. The final model incorporated vascular pattern, (normal/patchy/ complete obliteration) bleeding (none/mucosal/luminal mild/luminal moderate or severe), erosions and ulcers (none/erosions/superficial/deep), each with precise definitions, which explained 90% of the variance (pR2, Akaike Information Criterion) in the overall assessment of endoscopic severity, predictions varying from 4 to 93 on a 100-point scale (from normal to worst endoscopic severity). Conclusion: The Ulcerative Colitis Endoscopic Index of Severity accurately predicts overall assessment of endoscopic severity of UC. Validity and responsiveness need further testing before it can be applied as an outcome measure in clinical trials or clinical practice.publishersversionPeer reviewe

Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking

Lung cancer is the leading cause of cancer-related deaths worldwide, and lung squamous carcinomas (LUSC) represent about 30% of cases. Molecular aberrations in lung adenocarcinomas have allowed for effective targeted treatments, but corresponding therapeutic advances in LUSC have not materialized. However, immune checkpoint inhibitors in sub-populations of LUSC patients have led to exciting responses. Using computational analyses of The Cancer Genome Atlas, we identified a subset of LUSC tumors characterized by dense infiltration of inflammatory monocytes (IMs) and poor survival. With novel, immunocompetent metastasis models, we demonstrated that tumor cell derived CCL2-mediated recruitment of IMs is necessary and sufficient for LUSC metastasis. Pharmacologic inhibition of IM recruitment had substantial anti-metastatic effects. Notably, we show that IMs highly express Factor XIIIA, which promotes fibrin cross-linking to create a scaffold for LUSC cell invasion and metastases. Consistently, human LUSC samples containing extensive cross-linked fibrin in the microenvironment correlated with poor survival

Meta-analysis of type 2 Diabetes in African Americans Consortium

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, sex, study site, and principal components. Meta-analysis of approximately 2.6 million genotyped and imputed SNPs in all studies was conducted using an inverse variance-weighted fixed effect model. Replications were performed to follow up 21 loci in up to 6,061 cases and 5,483 controls in African Americans, and 8,130 cases and 38,987 controls of European ancestry. We identified three known loci (TCF7L2, HMGA2 and KCNQ1) and two novel loci (HLA-B and INS-IGF2) at genome-wide significance (4.15 × 10(-94)<P<5 × 10(-8), odds ratio (OR)  = 1.09 to 1.36). Fine-mapping revealed that 88 of 158 previously identified T2D or glucose homeostasis loci demonstrated nominal to highly significant association (2.2 × 10(-23) < locus-wide P<0.05). These novel and previously identified loci yielded a sibling relative risk of 1.19, explaining 17.5% of the phenotypic variance of T2D on the liability scale in African Americans. Overall, this study identified two novel susceptibility loci for T2D in African Americans. A substantial number of previously reported loci are transferable to African Americans after accounting for linkage disequilibrium, enabling fine mapping of causal variants in trans-ethnic meta-analysis studies.Peer reviewe