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Mapping The Interstellar Medium With Near-Infrared Diffuse Interstellar Bands
We map the distribution and properties of the Milky Way's interstellar medium as traced by diffuse interstellar bands (DIBs) detected in near-infrared stellar spectra from the SDSS-III/APOGEE survey. Focusing exclusively on the strongest DIB in the H band, at lambda similar to 1.527 mu m, we present a projected map of the DIB absorption field in the Galactic plane, using a set of about 60,000 sightlines that reach up to 15 kpc from the Sun and probe up to 30 mag of visual extinction. The strength of this DIB is linearly correlated with dust reddening over three orders of magnitude in both DIB equivalent width (Wpm) and extinction, with a power law index of 1.01 +/- 0.01, a mean relationship of W-DIB/A(v) = 0.1 angstrom mag(-1) and a dispersion of similar to 0.05 angstrom mag(-1) at extinctions characteristic of the Galactic midplane. These properties establish this DIB as a powerful, independent probe of dust extinction over a wide range of Av values. The subset of about 14,000 robustly detected DIB features have a W-DIB distribution that follows an exponential trend. We empirically determine the intrinsic rest wavelength of this transition to be lambda(0) = 15 272.42 angstrom and use it to calculate absolute radial velocities of the carrier, which display the kinematical signature of the rotating Galactic disk. We probe the DIB carrier distribution in three dimensions and show that it can be characterized by an exponential disk model with a scale height of about 100 pc and a scale length of about 5 kpc. Finally, we show that the DIB distribution also traces large-scale Galactic structures, including the Galactic long bar and the warp of the outer disk.NSF Astronomy & Astrophysics Postdoctoral Fellowship AST-1203017NSF AST-1109665Alfred P. Sloan FoundationNational Science FoundationU.S. Department of Energy Office of ScienceUniversity of ArizonaBrazilian Participation GroupBrookhaven National LaboratoryUniversity of CambridgeCarnegie Mellon UniversityUniversity of FloridaFrench Participation GroupGerman Participation GroupHarvard UniversityInstituto de Astrofisica de CanariasMichigan State/Notre Dame/JINA Participation GroupJohns Hopkins UniversityLawrence Berkeley National LaboratoryMax Planck Institute for AstrophysicsMax Planck Institute for Extraterrestrial PhysicsNew Mexico State UniversityNew York UniversityOhio State UniversityPennsylvania State UniversityUniversity of PortsmouthPrinceton UniversitySpanish Participation GroupUniversity of TokyoUniversity of UtahVanderbilt UniversityUniversity of VirginiaUniversity of WashingtonYale UniversitySpanish Ministry of Economy and Competitiveness AYA-2011-27754McDonald Observator
A simple umbelliferone based fluorescent probe for the detection of nitroreductase
A simple nitrobenzyl-umbelliferone (NCOU1) was synthesised containing a nitroreductase (NTR) trigger moiety. The presence of NTR, resulted in the fragmentation of the parent molecule and release of the highly emissive fluorophore umbelliferone via an NTR-catalyzed reduction of the nitro group. In the presence of the NTR enzyme, NCOU1 gave rise to a 5-fold increase in fluorescence intensity at 455 nm and was selective for NTR over other reductive enzymes. These results indicate that NCOU1 can be used as a simple assay for the detection of NTR
What the resonance peak cannot do
In certain cuprates, a spin 1 resonance mode is prominent in the magnetic
structure measured by neutron scattering. It has been proposed that this mode
is responsible for significant features seen in other spectroscopies, such as
photoemission and optical absorption, which are sensitive to the charge
dynamics, and even that this mode is the boson responsibile for ``mediating''
the superconducting pairing. We show that its small (measured) intensity and
weak coupling to electron-hole pairs (as deduced from the measured lifetime)
disqualifies the resonant mode from either proposed role.Comment: 4 pages, no figur
Recommendations of the LHC Dark Matter Working Group: Comparing LHC searches for heavy mediators of dark matter production in visible and invisible decay channels
Weakly-coupled TeV-scale particles may mediate the interactions between
normal matter and dark matter. If so, the LHC would produce dark matter through
these mediators, leading to the familiar "mono-X" search signatures, but the
mediators would also produce signals without missing momentum via the same
vertices involved in their production. This document from the LHC Dark Matter
Working Group suggests how to compare searches for these two types of signals
in case of vector and axial-vector mediators, based on a workshop that took
place on September 19/20, 2016 and subsequent discussions. These suggestions
include how to extend the spin-1 mediated simplified models already in
widespread use to include lepton couplings. This document also provides
analytic calculations of the relic density in the simplified models and reports
an issue that arose when ATLAS and CMS first began to use preliminary numerical
calculations of the dark matter relic density in these models.Comment: 19 pages, 4 figures; v2: author list and LaTeX problem fixe
Chemical Cartography with APOGEE: Large-scale Mean Metallicity Maps of the Milky Way
We present Galactic mean metallicity maps derived from the first year of the
SDSS-III APOGEE experiment. Mean abundances in different zones of
Galactocentric radius (0 < R < 15 kpc) at a range of heights above the plane (0
< |z| < 3 kpc), are derived from a sample of nearly 20,000 stars with
unprecedented coverage, including stars in the Galactic mid-plane at large
distances. We also split the sample into subsamples of stars with low and
high-[{\alpha}/M] abundance ratios. We assess possible biases in deriving the
mean abundances, and find they are likely to be small except in the inner
regions of the Galaxy. A negative radial gradient exists over much of the
Galaxy; however, the gradient appears to flatten for R < 6 kpc, in particular
near the Galactic mid-plane and for low-[{\alpha}/M] stars. At R > 6 kpc, the
gradient flattens as one moves off of the plane, and is flatter at all heights
for high-[{\alpha}/M] stars than for low-[{\alpha}/M] stars. Alternatively,
these gradients can be described as vertical gradients that flatten at larger
Galactocentric radius; these vertical gradients are similar for both low and
high-[{\alpha}/M] populations. Stars with higher [{\alpha}/M] appear to have a
flatter radial gradient than stars with lower [{\alpha}/M]. This could suggest
that the metallicity gradient has grown steeper with time or, alternatively,
that gradients are washed out over time by migration of stars.Comment: 16 pages, 12 figures, submitted to A
Tracing chemical evolution over the extent of the Milky Way's Disk with APOGEE Red Clump Stars
We employ the first two years of data from the near-infrared, high-resolution
SDSS-III/APOGEE spectroscopic survey to investigate the distribution of
metallicity and alpha-element abundances of stars over a large part of the
Milky Way disk. Using a sample of ~10,000 kinematically-unbiased red-clump
stars with ~5% distance accuracy as tracers, the [alpha/Fe] vs. [Fe/H]
distribution of this sample exhibits a bimodality in [alpha/Fe] at intermediate
metallicities, -0.9<[Fe/H]<-0.2, but at higher metallicities ([Fe/H]=+0.2) the
two sequences smoothly merge. We investigate the effects of the APOGEE
selection function and volume filling fraction and find that these have little
qualitative impact on the alpha-element abundance patterns. The described
abundance pattern is found throughout the range 5<R<11 kpc and 0<|Z|<2 kpc
across the Galaxy. The [alpha/Fe] trend of the high-alpha sequence is
surprisingly constant throughout the Galaxy, with little variation from region
to region (~10%). Using simple galactic chemical evolution models we derive an
average star formation efficiency (SFE) in the high-alpha sequence of ~4.5E-10
1/yr, which is quite close to the nearly-constant value found in
molecular-gas-dominated regions of nearby spirals. This result suggests that
the early evolution of the Milky Way disk was characterized by stars that
shared a similar star formation history and were formed in a well-mixed,
turbulent, and molecular-dominated ISM with a gas consumption timescale (1/SFE)
of ~2 Gyr. Finally, while the two alpha-element sequences in the inner Galaxy
can be explained by a single chemical evolutionary track this cannot hold in
the outer Galaxy, requiring instead a mix of two or more populations with
distinct enrichment histories.Comment: 18 pages, 17 figures. Accepted for publication in Ap
Type Ia Supernova Distances at z > 1.5 from the Hubble Space Telescope Multi-Cycle Treasury Programs: The Early Expansion Rate
We present an analysis of 15 Type Ia supernovae (SNe Ia) at redshift z > 1 (9
at 1.5 < z < 2.3) recently discovered in the CANDELS and CLASH Multi-Cycle
Treasury programs using WFC3 on the Hubble Space Telescope. We combine these
SNe Ia with a new compilation of 1050 SNe Ia, jointly calibrated and corrected
for simulated survey biases to produce accurate distance measurements. We
present unbiased constraints on the expansion rate at six redshifts in the
range 0.07 < z < 1.5 based only on this combined SN Ia sample. The added
leverage of our new sample at z > 1.5 leads to a factor of ~3 improvement in
the determination of the expansion rate at z = 1.5, reducing its uncertainty to
~20%, a measurement of H(z=1.5)/H0=2.67 (+0.83,-0.52). We then demonstrate that
these six measurements alone provide a nearly identical characterization of
dark energy as the full SN sample, making them an efficient compression of the
SN Ia data. The new sample of SNe Ia at z > 1 usefully distinguishes between
alternative cosmological models and unmodeled evolution of the SN Ia distance
indicators, placing empirical limits on the latter. Finally, employing a
realistic simulation of a potential WFIRST SN survey observing strategy, we
forecast optimistic future constraints on the expansion rate from SNe Ia.Comment: 14 pages, 5 figures, 7 tables; submitted to Ap
Type Ia Supernova Rate Measurements To Redshift 2.5 From CANDELS: Searching For Prompt Explosions In The Early Universe
dThe Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS) was a multi-cycle treasury program on the Hubble Space Telescope (HST) that surveyed a total area of -0.25 deg2 with -900 HST orbits spread across five fields over three years. Within these survey images we discovered 65 supernovae (SNe) of all types, out to z 2.5. We classify -24 of these as Type Ia SNe (SNe Ia) based on host galaxy redshifts and SN photometry (supplemented by grism spectroscopy of six SNe). Here we present a measurement of the volumetric SN Ia rate as a function of redshift, reaching for the first time beyond z =- 2 and putting new constraints on SN Ia progenitor models. Our highest redshift bin includes detections of SNe that exploded when the universe was only -3 Gyr old and near the peak of the cosmic star formation history. This gives the CANDELS high redshift sample unique leverage for evaluating the fraction of SNe Ia that explode promptly after formation ( 40 Myr. However, mild tension is apparent between ground-based low-z surveys and space-based high-z surveys. In both CANDELS and the sister HST program CLASH (Cluster Lensing And Supernova Survey with Hubble), we find a low rate of SNe Ia at z > 1. This could be a hint that prompt progenitors are in fact relatively rare, accounting for only 20% of all SN Ia explosions-though further analysis and larger samples will be needed to examine that suggestion. Key words: infrared: general - supernovae:Astronom
Adding Spin Functionality to Traditional Optoelectronics via Chiral Perovskite
Spin polarized current generation and injection into semiconductors at room
temperature are key to enable a broader range of opto-spintronic
functionalities, yet the inherent efficiency of spin injection across commonly
used semiconductor-ferromagnet interfaces is limited. Here, we demonstrate
efficient spin injection into commercially viable III-V light emitting diodes
(LED) by integrating chiral halide perovskite layers with (AlxGa1-x)0.5In0.5P
multiple quantum wells (MQW). Spin polarized current is injected via chirality
induced spin selectivity (CISS) and the spin accumulation in the III-V
semiconductor is detected via the emission of circularly polarized light with a
degree of circular polarization of up to ~ 15%. X-ray photoemission
spectroscopy (XPS) and transmission electron microscopy (TEM) cross sectional
imaging indicate a pristine perovskite/III-V interface. These findings
demonstrate chiral perovskite semiconductors transform well-developed
semiconductor platforms to enable control over spin, charge, and light
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons. Understanding the mechanisms that influence Htt cellular degradation may target treatments designed to activate mutant Htt clearance pathways. We find that Htt is phosphorylated by the inflammatory kinase IKK, enhancing its normal clearance by the proteasome and lysosome. Phosphorylation of Htt regulates additional post-translational modifications, including Htt ubiquitination, SUMOylation, and acetylation, and increases Htt nuclear localization, cleavage, and clearance mediated by lysosomal-associated membrane protein 2A and Hsc70. We propose that IKK activates mutant Htt clearance until an age-related loss of proteasome/lysosome function promotes accumulation of toxic post-translationally modified mutant Htt. Thus, IKK activation may modulate mutant Htt neurotoxicity depending on the cell's ability to degrade the modified species
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