Solar Nebula Magnetohydrodynamics

The dynamical state of the solar nebula depends critically upon whether or not the gas is magnetically coupled. The presence of a subthermal field will cause laminar flow to break down into turbulence. Magnetic coupling, in turn, depends upon the ionization fraction of the gas. The inner most region of the nebula ($\lesssim 0.1$ AU) is magnetically well-coupled, as is the outermost region ($\gtrsim 10$ AU). The magnetic status of intermediate scales ($\sim 1$ AU) is less certain. It is plausible that there is a zone adjacent to the inner disk in which turbulent heating self-consistently maintains the requisite ionization levels. But the region adjacent to the active outer disk is likely to be magnetically ``dead.'' Hall currents play a significant role in nebular magnetohydrodynamics. Though still occasionally argued in the literature, there is simply no evidence to support the once standard claim that differential rotation in a Keplerian disk is prone to break down into shear turbulence by nonlinear instabilities. There is abundant evidence---numerical, experimental, and analytic---in support of the stabilizing role of Coriolis forces. Hydrodynamical turbulence is almost certainly not a source of enhanced turbulence in the solar nebula, or in any other astrophysical accretion disk.Comment: 19 pages, LaTEX, ISSI Space Sciences Series No.

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser(487) in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-α1 (AMP-activated protein kinase-α1), leading to inhibition of phosphorylation by upstream kinases at the activating site, Thr(172). Surprisingly, the equivalent site on AMPK-α2, Ser(491), is not an Akt target and is modified instead by autophosphorylation. Stimulation of HEK (human embryonic kidney)-293 cells with IGF-1 caused reduced subsequent Thr(172) phosphorylation and activation of AMPK-α1 in response to the activator A769662 and the Ca(2+) ionophore A23187, effects we show to be dependent on Akt activation and Ser(487) phosphorylation. Consistent with this, in three PTEN (phosphatase and tensin homologue deleted on chromosome 10)-null tumour cell lines (in which the lipid phosphatase PTEN that normally restrains the Akt pathway is absent and Akt is thus hyperactivated), AMPK was resistant to activation by A769662. However, full AMPK activation could be restored by pharmacological inhibition of Akt, or by re-expression of active PTEN. We also show that inhibition of Thr(172) phosphorylation is due to interaction of the phosphorylated ST loop with basic side chains within the αC-helix of the kinase domain. Our findings reveal that a previously unrecognized effect of hyperactivation of Akt in tumour cells is to restrain activation of the LKB1 (liver kinase B1)–AMPK pathway, which would otherwise inhibit cell growth and proliferation

Detecting Differential Rotation and Starspot Evolution on the M dwarf GJ 1243 with Kepler

We present an analysis of the starspots on the active M4 dwarf GJ 1243, using four years of time series photometry from Kepler. A rapid $P = 0.592596\pm0.00021$ day rotation period is measured due to the $\sim$2.2\% starspot-induced flux modulations in the light curve. We first use a light curve modeling approach, using a Monte Carlo Markov Chain sampler to solve for the longitudes and radii of the two spots within 5-day windows of data. Within each window of time the starspots are assumed to be unchanging. Only a weak constraint on the starspot latitudes can be implied from our modeling. The primary spot is found to be very stable over many years. A secondary spot feature is present in three portions of the light curve, decays on 100-500 day timescales, and moves in longitude over time. We interpret this longitude shearing as the signature of differential rotation. Using our models we measure an average shear between the starspots of 0.0047 rad day$^{-1}$, which corresponds to a differential rotation rate of $\Delta\Omega = 0.012 \pm 0.002$ rad day$^{-1}$. We also fit this starspot phase evolution using a series of bivariate Gaussian functions, which provides a consistent shear measurement. This is among the slowest differential rotation shear measurements yet measured for a star in this temperature regime, and provides an important constraint for dynamo models of low mass stars.Comment: 13 pages, 7 figures, ApJ Accepte

Medical education on fitness to drive : a survey of all UK medical schools

Aim: To identify the extent to which medical aspects of fitness to drive (FTD) are taught within UK medical schools. Methods: A survey of all 32 UK medical schools. In-depth interviews with a range of staff at two medical schools; telephone survey of 30 schools. Results: Two thirds of schools reported specific teaching on medical aspects of FTD but few covered it in any depth or in relation to specific medical conditions. Only one school taught FTD in relation to elderly medicine. FTD was an examination topic at only 12 schools. Conclusion: Teaching on FTD is inconsistent across UK medical schools. Many new doctors will graduate with limited knowledge of medical aspects of FTD

Developing a systems and informatics based approach to lifestyle monitoring within eHealth:part I - technology and data management

Lifestyle monitoring forms a subset of telecare in which data derived from sensors located in the home is used to identify variations in behaviour which are indicative of a change in care needs. Key to this is the performance of the sensors themselves and the way in which the information from multiple sources is integrated within the decision making process. The paper therefore considers the functions of the key sensors currently deployed and places their operation within the context of a proposed multi-level system structure which takes due cognisance of the requisite informatics framework

Chaos in Turbulence Driven by the Magnetorotational Instability

Chaotic flow is studied in a series of numerical magnetohydrodynamical simulations that use the shearing box formalism. This mimics important features of local accretion disk dynamics. The magnetorotational instability gives rise to flow turbulence, and quantitative chaos parameters, such as the largest Lyapunov exponent, can be measured. Linear growth rates appear in these exponents even when the flow is fully turbulent. The extreme sensitivity to initial conditions associated with chaotic flows has practical implications, the most important of which is that hundreds of orbital times are needed to extract a meaningful average for the stress. If the evolution time in a disk is less than this, the classical $\alpha$ formalism will break down.Comment: 6 pages, 8 figures. To be appear in MNRA