65 research outputs found
Testosterone, Sex Hormone-Binding Globulin and the Metabolic Syndrome in Men: An Individual Participant Data Meta-Analysis of Observational Studies
Peer reviewe
Fathers’ narratives on support and agency: a case study of fathers in a Finnish child welfare NGO
Correcting oral contraceptive pharmacokinetic alterations due to obesity: a randomized controlled trial
Detection of Rotavirus in Faecal Specimens by Enzyme Immunoassay, Latex Agglutination and Electron Microscopy
Lack of Association between Genetic Polymorphism of CYP11B2 and Hypertension in Japanese: The Suita Study.
The associations of endogenous testosterone and sex hormone-binding globulin with glycosylated hemoglobin levels, in community dwelling men. The Tromsø Study
The C282Y polymorphism of the hereditary hemochromatosis gene is associated with increased sex hormone-binding globulin and normal testosterone levels in men
BackgroundHereditary hemochromatosis resulting either from homozygosity for the C282Y polymorphism of the HFE gene, or compound heterozygosity for C282Y and H63D, manifests with liver disease and hypogonadism. However, it is unclear whether men who are heterozygotes for C282Y or H63D exhibit subtle abnormalities of sex hormone status.AimsTo evaluate whether heterozygosity for either of the HFE gene polymorphisms C282Y or H63D is associated with circulating testosterone and SHBG in men.Subjects and methodsWe performed a cross-sectional analysis of 388 community-dwelling men. Men were genotyped for C282Y and H63D. Sera were analysed for testosterone and SHBG, and insulin resistance was estimated using a homeostatic model (HOMA2-IR).ResultsMean age of men in the cohort was 56.9 yr. Men who were heterozygous for the C282Y polymorphism in the HFE gene had higher SHBG levels than men who did not carry this polymorphism (mean ± SE, 38.2 ± 1.64 vs 32.8 ± 0.71 nmol/l, p=0.006). Total and free testosterone levels did not differ in the two groups. In multivariate analysis adjusting for potential confounders including age, waist circumference, testosterone, and HOMA2-IR, C282Y heterozygosity remained associated with SHBG levels (pConclusionThe C282Y polymorphism is associated with SHBG levels in men who do not manifest iron overload. Further studies are needed to clarify potential mechanisms and determine the clinical relevance of this finding.B.B. Yeap, J. Beilin, Z. Shi, M.W. Knuiman, J.K. Olynyk, S.A.P. Chubb, D.G. Bruce, and E.A. Milwardhttp://www.ncbi.nlm.nih.gov/pubmed/2016046
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