Multifacet holographic optical elements

New types of holographic optical elements, combining the flexibility of computer generated holograms with the large space bandwidth product and high diffraction efficiency of interferometrically recorded volume phase holograms, are demonstrated. The optical elements are recorded by subdividing a volume hologram film surface into numerous small areas (facets), each of which is individually exposed under computer control. Each facet is used to produce a portion of the desired final wavefront. Three different optical elements are demonstrated

Is nonhelical hydromagnetic turbulence peaked at small scales?

Nonhelical hydromagnetic turbulence without an imposed magnetic field is considered in the case where the magnetic Prandtl number is unity. The magnetic field is entirely due to dynamo action. The magnetic energy spectrum peaks at a wavenumber of about 5 times the minimum wavenumber in the domain, and not at the resistive scale, as has previously been argued. Throughout the inertial range the spectral magnetic energy exceeds the kinetic energy by a factor of about 2.5, and both spectra are approximately parallel. At first glance, the total energy spectrum seems to be close to k^{-3/2}, but there is a strong bottleneck effect and it is suggested that the asymptotic spectrum is k^{-5/3}. This is supported by the value of the second order structure function exponent that is found to be \zeta_2=0.70, suggesting a k^{-1.70} spectrum.Comment: 6 pages, 6 figure

Combination PPARγ and RXR Agonist Treatment in Melanoma Cells: Functional Importance of S100A2

Nuclear hormone receptors, including RXR and PPARγ, represent novel therapeutic targets in melanoma. We have previously shown that the DRO subline of the amelanotic melanoma A375 responds to rexinoid and thiazolidinedione (TZD) treatment in vitro and in vivo. We performed microarray analysis of A375(DRO) after TZD and combination rexinoid/TZD treatment in which the calcium binding protein S100A2 had increased expression after rexinoid or TZD treatment and a synergistic increase to combination treatment. Increased S100A2 expression is dependent on an intact PPARγ receptor, but it is not sufficient to mediate the antiproliferative effects of rexinoid/TZD treatment. Over expression of S100A2 enhanced the effect of rexinoid and TZD treatment while inhibition of S100A2 expression attenuated the response to rexinoid/TZD treatment, suggesting that S100A2 is necessary for optimal response to RXR and PPARγ activation by respective ligands. In summary, we have identified potential downstream mediators of rexinoid and TZD treatment in a poorly differentiated melanoma and found that alterations in S100A2 expression affect RXR and PPARγ signaling in A375(DRO) cells. These studies provide insight into potential mechanisms of tumor response or resistance to these novel therapies

The scaling properties of dissipation in incompressible isotropic three-dimensional magnetohydrodynamic turbulence

The statistical properties of the dissipation process constrain the analysis of large scale numerical simulations of three dimensional incompressible magnetohydrodynamic (MHD) turbulence, such as those of Biskamp and Muller [Phys. Plasmas 7, 4889 (2000)]. The structure functions of the turbulent flow are expected to display statistical self-similarity, but the relatively low Reynolds numbers attainable by direct numerical simulation, combined with the finite size of the system, make this difficult to measure directly. However, it is known that extended self-similarity, which constrains the ratio of scaling exponents of structure functions of different orders, is well satisfied. This implies the extension of physical scaling arguments beyond the inertial range into the dissipation range. The present work focuses on the scaling properties of the dissipation process itself. This provides an important consistency check in that we find that the ratio of dissipation structure function exponents is that predicted by the She and Leveque [Phys. Rev. Lett 72, 336 (1994)] theory proposed by Biskamp and Muller. This supplies further evidence that the cascade mechanism in three dimensional MHD turbulence is non-linear random eddy scrambling, with the level of intermittency determined by dissipation through the formation of current sheets.Comment: 9 pages, 6 figures. Figures embedded in text. Typos corrected in text and references. Published in Physics of Plasmas. Abstract can be found at:http://link.aip.org/link/?php/12/02230

Beta lives - some statistical perspectives on the capital asset pricing model

This note summarizes some technical issues relevant to the use of the idea of excess return in empirical modelling. We cover the case where the aim is to construct a measure of expected return on an asset and a model of the CAPM type is used. We review some of the problems and show examples where the basic CAPM may be used to develop other results which relate the expected returns on assets both to the expected return on the market and other factors

On the Saturation of Astrophysical Dynamos: Numerical Experiments with the No-cosines flow

In the context of astrophysical dynamos we illustrate that the no-cosines flow, with zero mean helicity, can drive fast dynamo action and study the dynamo's mode of operation during both the linear and non-linear saturation regime: It turns out that in addition to a high growth rate in the linear regime, the dynamo saturates at a level significantly higher than normal turbulent dynamos, namely at exact equipartition when the magnetic Prandtl number is on the order of unity. Visualization of the magnetic and velocity fields at saturation will help us to understand some of the aspects of the non-linear dynamo problem.Comment: 8 pages, 5 figures, submitted to the proceedings of "Space Climate 1" to be peer-reviewed to Solar Physic

Patient/Family Education for Newly Diagnosed Pediatric Oncology Patients

There is a paucity of data to support evidence-based practices in the provision of patient/family education in the context of a new childhood cancer diagnosis. Since the majority of children with cancer are treated on pediatric oncology clinical trials, lack of effective patient/family education has the potential to negatively affect both patient and clinical trial outcomes. The Children’s Oncology Group Nursing Discipline convened an interprofessional expert panel from within and beyond pediatric oncology to review available and emerging evidence and develop expert consensus recommendations regarding harmonization of patient/family education practices for newly diagnosed pediatric oncology patients across institutions. Five broad principles, with associated recommendations, were identified by the panel, including recognition that (1) in pediatric oncology, patient/family education is family-centered; (2) a diagnosis of childhood cancer is overwhelming and the family needs time to process the diagnosis and develop a plan for managing ongoing life demands before they can successfully learn to care for the child; (3) patient/family education should be an interprofessional endeavor with 3 key areas of focus: (a) diagnosis/treatment, (b) psychosocial coping, and (c) care of the child; (4) patient/family education should occur across the continuum of care; and (5) a supportive environment is necessary to optimize learning. Dissemination and implementation of these recommendations will set the stage for future studies that aim to develop evidence to inform best practices, and ultimately to establish the standard of care for effective patient/family education in pediatric oncology

DNA adducts in human urinary bladder and other tissues.

Tobacco smoking is associated with an increased risk of cancer in a number of organs, including bladder and lung. Tobacco smoke contains at least 50 known chemical carcinogens that exert their biological effects through their covalent binding to cellular DNA. Examining human DNA for the presence of altered nucleotides is a means of monitoring exposure to genotoxic chemicals. DNA isolated from 73 human bladder biopsies has been analyzed by 32P-postlabeling for the presence of aromatic/hydrophobic adducts. Butanol extraction of DNA digests resulted in up to a 3-fold greater recovery of adducts than nuclease P1 digestion. Among 16 nonsmokers, adduct levels were in the range 3.2-20.8/10(8) nucleotides (mean 9.7). Eight ex-smokers had values in the range 2.6-12.3 (mean 7.1). Thirteen smokers had adduct levels between 1.3 and 26.7 adducts/10(8) nucleotides (mean 9.5, not different from nonsmokers). Six cigar smokers had higher levels of adducts (mean 12.1, range 7.3-15.0), but pipe smokers did not (five samples, mean 8.6, range 2.9-12.7). A further 8 samples from nonsmokers and 17 from smokers were examined in more detail. Although most of the DNA binding appears not to be smoking related, the levels of one adduct were found to be on average 2-fold higher in smokers (p < 0.005, one-tailed t test). Studies on tissues of the respiratory tract demonstrate a correlation between DNA adduct levels and exposure to tobacco smoke. Evidence to date on the influence of smoking on adducts in peripheral blood cells is equivocal; some studies demonstrate a significant effect, whereas others do not.(ABSTRACT TRUNCATED AT 250 WORDS