37 research outputs found

    Electrical stimulation of the auditory nerve: the effect of electrode position on neural excitation

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    Publisher’s permission requested and denied.Histological studies have shown that the Melbourne/Cochlear electrode array lies along the outer wall of the scala tympani and is therefore some distance from the residual VIIIth nerve elements. In order to investigate the influence of electrode position on neural excitation we systematically varied the position of the electrode array within the cat scala tympani while recording electrically evoked auditory brainstem responses (EABRs). Using both normal hearing and long-term deafened animals, we observed significant reductions in EABR thresholds as the electrode array was moved from the outer wall towards the modiolus. Further threshold reductions were observed when the array was placed underneath the osseous spiral lamina (OSL) close to the peripheral dendrites. These changes were independent of the bipolar inter-electrode separation, and were observed over a wide range of cochlear pathologies varying from normal to a moderate spiral ganglion cell loss. Interestingly, the one animal exhibiting extensive neural loss showed no correlation between EABR threshold and electrode position. There was also a general decrease in the gradient of the EABR input-output function as the electrode array was moved closer to the neural elements. This was, however, only statistically significant when the electrode was positioned adjacent to the peripheral dendrites. Significant reductions in EABR threshold were also observed as the inter-electrode spacing of the bipolar electrodes was increased. The gradient of the EABR input-output function also increased with increasing inter-electrode spacing, although again, this was only significant when the electrode array was positioned close to the neural elements. The present results indicate that the optimum placement of a Melbourne/Cochlear electrode array is adjacent to the peripheral dendrites. However, such a site would be difficult to achieve in practice while minimizing insertion trauma. An array lying adjacent to the modiolus would be a safe alternative while ensuring a significant reduction in threshold compared with the existing site (outer wall). This placement should result in more localized neural excitation patterns, an increase in the number of bipolar electrodes available, together with an increase in their dynamic range. These changes may lead to further improvements in speech perception among cochlear implant patients

    The influence of electrode geometry on the electrically evoked auditory brain stem response

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    The electrically-evoked auditory brainstem response (EABR) consists of a series of far-field potentials that reflect synchronous neural activity within the auditory brainstem in response to a transient electrical stimulus. The EABR appears relatively simply organized in terms of its amplitude and latency behaviour. The growth in amplitude of wave IV of the EABR, for example, reflects changes in the amplitude of the electrically-evoked VIII nerve compound action potential as a function of stimulus intensity. In addition, single unit population studies have shown a monotonic relationship between the growth in EABR amplitude and the number of nerve fibres being stimulated (Merzenich and White, 1977). The EABR can therefore, provide an insight into the response of the auditory nerve to electrical stimulation. We have used this technique to investigate the efficacy of electrical stimulation of the auditory nerve using a variety of stimulating electrode geometries

    Simulating river discharge in a snowy region of Japan using output from a regional climate model

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    Snowfall amounts have fallen sharply along the eastern coast of the Sea of Japan since the mid-1980s. Toyama Prefecture, located approximately in the center of the Japan Sea region, includes high mountains of the northern Japanese Alps on three of its sides. The scarcity of meteorological observation points in mountainous areas limits the accuracy of hydrological analysis. With the development of computing technology, a dynamical downscaling method is widely applied into hydrological analysis. In this study, we numerically modeled river discharge using runoff data derived by a regional climate model (4.5-km spatial resolution) as input data to river networks (30-arcseconds resolution) for the Toyama Prefecture. The five main rivers in Toyama (the Oyabe, Sho, Jinzu, Joganji, and Kurobe rivers) were selected in this study. The river basins range in area from 368 to 2720 km2. A numerical experiment using climate comparable to that at present was conducted for the 1980s and 1990s. The results showed that seasonal river discharge could be represented and that discharge was generally overestimated compared with measurements, except for Oyabe River discharge, which was always underestimated. The average correlation coefficient for 10-year average monthly mean discharge was 0.8, with correlation coefficients ranging from 0.56 to 0.88 for all five rivers, whereas the Nash-Sutcliffe efficiency coefficient indicated that the simulation accuracy was insufficient. From the water budget analysis, it was possible to speculate that the lack of accuracy of river discharge may be caused by insufficient accuracy of precipitation simulation
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