Avaliação dos resultados de componente femoral cônico de fixação proximal não cimentado em fêmur tipo C de Dorr

Orientador :Monografia (especialização) - Universidade Federal do Paraná, Setor de ..., Curso de Especialização em ...Inclui referência

Parâmetros para avaliação morfológica da parte distal do acetábulo em 300 quadris adultos

Orientador: Prof. Dr. Luiz Antônio Munhoz da CunhaDissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Clínica Cirúrgica. Defesa: Curitiba, 20/05/2016Inclui referências: f 41-43Área de concentraçãoResumo: Introdução: A parte distal do acetábulo (PDA) tem sido investigada como estabilizador do quadril em posições de flexão, com possíveis implicações na patogenia do impacto femoroacetabular e da instabilidade do quadril. Entretanto, é necessário um maior entendimento da morfologia normal e dos parâmetros para avaliar a PDA. Objetivos: Definir os parâmetros para avaliar a morfologia da PDA. Especificamente, os objetivos foram determinar: 1) a largura do corno anterior (CA) e corno posterior (CP) do acetábulo; 2) a inclinação da superfície articular do CA (ângulo gama) e CP (ângulo delta); 3) o ângulo de abertura anterior da PDA; (4) possíveis diferenças entre os gêneros masculino e feminino. Material e Métodos: Paquímetros digitais foram utilizados para realizar medidas diretamente em acetábulos de 300 ossos inominados de esqueletos adultos. Na sequência, os ossos inominados direito e esquerdo de cada esqueleto foram montados ao sacro e 150 pelves foram fotografadas digitalmente em posições padronizadas. Parâmetros angulares foram então aferidos em cada acetábulo utilizando o programa de computador Adobe Photoshop. Resultados: A largura média do CA foi de 14,8mm (variando de 9,44 a 20,88mm). A largura média do CP foi de 19,72mm (variando de 13,16 a 25,86mm). As larguras do CA e do CP foram maiores em acetábulos masculinos comparados aos femininos (p<0.001). Entretanto, não houve diferença entre gêneros quando a largura do CA foi corrigida ao diâmetro acetabular. O ângulo gama médio foi de 43,58 (variando de 24,70 a 64 ). O ângulo delta médio foi de 36,07 (variando de 16,10 a 53,20 ). O ângulo de abertura anterior da PDA foi em média 25,33 (variando de 10.90 a 43.10 ). Conclusão: O CA do acetábulo apresenta largura menor e inclinação maior da superfície articular em comparação ao CP. Os diâmetros dos cornos acetabulares não diferiram entre homens e mulheres quando corrigidos à dimensão acetabular, porém houve diferença entre os gêneros nas inclinações das superfícies articulares da parte distal do acetábulo.Abstract: Background: The inferior acetabulum (IA) has been studied as a stabilizer of the hip in flexed positions with potential implications in femoroacetabular impingement and hip instability. However, there is a need for a better understanding of the normal morphology and parameters for the assessment of the IA. Purposes: To define parameters to assess the IA morphology and their normal range. Specifically, the objectives were to assess: 1) the width of the anterior horn (AH) and posterior horn (PH) of the acetabulum; 2) the inclination of the articular surface of the AH (gamma angle) and PH (delta angle); (3) the anterior opening angle of the IA; (4) differences between genders. Methods: Measurements were directly taken from acetabula in 300 adult innominate bones utilizing digital calipers. In sequence, the right and left innominate bones were assembled to sacrum in each skeleton and 150 pelvises were digitally photographed in standardized positions. Angular parameters of the acetabulum were then measured utilizing the Adobe Photoshop software. Results: The mean width of the AH was 14,8mm (range, 9,44 to 20,88mm). The mean width of the PH was 19.72mm (range, 13,16 to 25,86mm). The AH and PH width was higher in male than female acetabula (p<0.001). However, no genderrelated difference was observed in the width of the AH when corrected to the acetabular size. The mean gamma angle was 43,58 (range, 24,70 to 64 ). The mean delta angle was 36,07 (range, 16,10 to 53,20 ). The mean anterior opening angle of the IA was 25.33 (range, 10.90 to 43.10 ). Conclusion: The articular surface of the AH has a smaller width but a larger inclination in comparison to the PH. The widths of the acetabular horns corrected by the acetabular diameter are not different between male and female, however, the inclination of the articular surfaces of the IA were different between genders

Diagnostic value of angiopoietin-1 and -2 as markers for disease severity in hemolytic uremic syndrome in children

Introduction: Hemolytic uremic syndrome (HUS) is defined as a triad of microangiopathic hemolytic anemia (MHA), thrombocytopenia, and acute renal failure. It is the most common cause of acute renal failure in children, and the incidence of this syndrome is increasing worldwide. Angiopoietin-1 and -2 each competitively bind to the endothelial Tie-2 receptor and play an important role in regulating endothelial cell function. The aim of this study was investigating the clinical significance of serum levels of angiopoietin (Ang) 1 and 2 in enterohemorrhagic Escherichia Coli (EHEC)-induced HUS and determining their correlation with disease severity.Patients and Methods: Forty eight children aged between 1-16 years were included in the study and were divided into two groups, 24 patients with diagnosis of hemolytic uremic syndrome induced by EHEC infection and 24 healthy children as a control group. Serum samples were obtained from healthy control group and patients with EHEC-induced HUS at time of diagnosis. Serum samples from the patients were obtained for analysis for angiopoietin-1 and -2 by enzyme-linked immunosorbent assay.Results: Our findings indicated that, serum Ang-1 levels might be useful for the prediction of the development of HUS. In HUS phase, in addition to more significant decrease of serum Ang-1 levels, serum Ang-2 level increased. These changes might be useful for the diagnosis of HUS and also be useful as a marker of disease activity of HUS.Conclusion: Serum angiopoietin-1 and angiopoietin-2 levels and the Ang-2/Ang-1 ratio may be promising indicators of disease activity in HUS

How Does Forecasting Affect the Convergence of DRL Techniques in O-RAN Slicing?

The success of immersive applications such as virtual reality (VR) gaming and metaverse services depends on low latency and reliable connectivity. To provide seamless user experiences, the open radio access network (O-RAN) architecture and 6G networks are expected to play a crucial role. RAN slicing, a critical component of the O-RAN paradigm, enables network resources to be allocated based on the needs of immersive services, creating multiple virtual networks on a single physical infrastructure. In the O-RAN literature, deep reinforcement learning (DRL) algorithms are commonly used to optimize resource allocation. However, the practical adoption of DRL in live deployments has been sluggish. This is primarily due to the slow convergence and performance instabilities suffered by the DRL agents both upon initial deployment and when there are significant changes in network conditions. In this paper, we investigate the impact of time series forecasting of traffic demands on the convergence of the DRL-based slicing agents. For that, we conduct an exhaustive experiment that supports multiple services including real VR gaming traffic. We then propose a novel forecasting-aided DRL approach and its respective O-RAN practical deployment workflow to enhance DRL convergence. Our approach shows up to 22.8%, 86.3%, and 300% improvements in the average initial reward value, convergence rate, and number of converged scenarios respectively, enhancing the generalizability of the DRL agents compared with the implemented baselines. The results also indicate that our approach is robust against forecasting errors and that forecasting models do not have to be ideal.Comment: This article has been accepted for presentation in IEEE GLOBECOM 202

Thermophysical and thermal cyclic behavior of nano-enhanced molten salts for concentrated solar power

There are definite trends towards maximizing the utilization efficiency of solar energy through concentrated solar power (CSP) by using molten salts, which have enhanced the efficiency of CSP plants since they replaced thermal oil as heat transfer fluids (HTF) and as thermal energy storage (TES). However, these molten salts have limited TES properties. These thermophysical properties can be enhanced by adding a small amount of nanoparticles to the base salt, which may enhance the overall efficiency of the CSP systems. The purpose of this work is to characterize HITEC with various nanoparticles and assess the impact of varying nanoparticle concentrations on the thermophysical properties of the formulated Nano-Enhanced HITEC Molten Salt (NEHMS) samples. It also seeks to examine the long-term thermal cycle stability of these properties as well as to assess the impact of the improved thermophysical properties of NEHMS on electricity price and the efficiency of the CSP plant. NEHMS were synthesized using CuO, TiO2, and h-BN nanoparticles separately at different concentrations (0.1, 0.5, and 1.0 wt.%). The NEHMS samples were characterized for compatibility and nanostructure analysis. The thermophysical properties and thermal cyclic behaviour of the nano-HITEC samples were evaluated to find the optimum sample. Furthermore, the impact of improving thermophysical properties on efficiency and electricity cost was assessed. The wet preparation method was used to formulate HITEC and NEHMS samples. The compatibility of HITEC with the nanoparticles was analysed with FTIR spectroscopy. DSC was utilized to evaluate the specific heat capacity, melting point, and latent heat of HITEC and NEHMS samples. Thermal stability was measured by TGA while the characterization analysis was performed using FESEM, and EDX. The thermal cyclic stability of the optimum samples was done in this study to evaluate the stability of the enhanced properties after 100 cycles. Also, the simulation was used to examine the effect of applying the optimum samples on the efficiency of the CSP plant and the cost of producing electricity and compared the results of the optimum sample with those of the currently used HTF and TES solar salt. The results showed that 0.1wt.% nanoparticles is the optimum concentration which resulted in the best thermophysical properties enhancement. The heat capacity was enhanced by 5.6%, 27%, and 5.5%, latent heat by 30%, 72%, and 78%, and thermal stability by 9%, 7%, and 5% for HITEC with 0.1 wt.% CuO, 0.1 wt.% h-BN, and 0.1 wt.% TiO2 nanoparticles respectively. The morphological analysis revealed a good dispersion of nanoparticles in HITEC and the formation of a bright chain-like nanostructure due to nanoparticle dispersion. The FTIR showed the stability of the nanofluid mixture without any chemical reaction between HITEC and the used nanoparticles. The thermal cyclic stability showed the stability of the nanocomposite and the enhanced properties. The CSP efficiency evaluation revealed that employing the optimum sample would improve CSP plant efficiency by 1.4%, and lower power costs by 0.13 ¢/kWh. The outcomes of this research reduce the gap of finding the optimum salt for CSP systems which may result in a reduction of the electricity price and an increase in the dependency on solar energy as a clean electricity source. This study contributes to the 10-10 MYSTIE (No.1 Energy, and No.10 Environment and Biodiversity) and the 17 SDGs (No.7 Affordable and Clean Energy, and No.13 Climate Action)

Study of serum levels of visfatin amongst pre-diabetic obese patients

Background: Insulin resistance, pre-diabetes, and obesity have all been linked to excess adiposity. Proinflammatory adipokine visfatin is thought to play a key role in type 2 diabetes inflammation. Objective: This study aimed to estimate visfatin level among prediabetic obese patients and to observe and detect the interplay between visfatin, insulin resistance and obesity.Patients and methods: 96 adult subjects were studied in case-control research at Internal Medicine Department and Clinical Pathology Department, Zagazig University Hospital. The study was carried out from January 2021 to November 2021. Subjects were divided into 3 groups: Group (1) included 24 healthy individuals as a control group, group (2) included 48 prediabetic individuals and group (3) that included 24 patients type 2 diabetes who never been treated in any of these. Serum visfatin was assessed in all participants.Results: Diabetes mellitus (DM) patients had higher visfatin levels than those with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG). Visfatin had a significant positive correlation with BMI, WC, FBS, PPS, HA1c, LDL, fasting insulin, and HOMA IR, while HDL had a significant negative correlation.Conclusion: Visfatin levels were significantly linked to type 2 diabetes. HOMA-IR, fasting insulin, and BMI all showed a strong positive correlation with visfatin levels, suggesting that it may be a useful biomarker for detecting type 2 diabetes

PIMASERTIB and SEROUS RETINAL DETACHMENTS

© by Ophthalmic Communications Society, Inc.Purpose: To report a case of multifocal serous retinal detachments associated with pimasertib. Methods: The authors report a 26-year-old patient who developed bilateral multifocal serous retinal detachments appearing 2 days after starting pimasertib (as part of a clinical trial investigating its use in low-grade metastatic ovarian cancer) and rapidly resolving 3 days after stopping it. Conclusion: The mechanism of MEK inhibitor induced visual toxicity remains unclear. The pathophysiology of multifocal serous retinal detachments as a complication of pimasertib is still poorly understood. Copyringhtpublished_or_final_versio

An Analytical Study Of Educational Administration Master Theses Approved In Al_Quds University

This study aims at identifying the reality of Educational Administration master theses approved in Al Quds University master’s program in Educational Administration during (1998-2021). The study population consisted of the (370) master theses approved during the program, while the study sample was a simple random sample of (100) theses. The researcher used descriptive approach to analyze the contents of these theses. The results of study showed, through a content analysis card, that the quantitative descriptive approach (with one variable) is the most common approach used by (89%). Master thesis revolved around school administration was the most common thesis by (33%). Subjects of education economics was researched modestly in the master thesis by (0%). In connection with samples, the random sample, particularly stratified, was the most common sample used by (55%). Comprehensive survey was limitedly used by (19%). The questionnaire was the most frequently used tool in the thesis by (94). Pearson correlation with arbitrator’s credibility was the most common method used to verify the credibility of the study. Cronbach Alfa is the most common method used to verify reliability of study tools. Percentage of thesis male supervisors was very high by (96), in comparison to female supervisors, whose percentage was (4%). Female researchers’ percentage was (60%), which is higher than male researchers’ percentage of (40%). Most thesis used statistical inference by (81%), T-Test, and One Way Anova by (81%). Neither Second Way Anova, nor Manova were used in the thesis. Analysis results showed also other matters

Application of Sulfur-2,4-dinitrophenylhydrazine as Modifier for Producing an Advantageous Concrete

في هذا المسعى الاستقصائي ، تم تطوير نوع جديد من الخرسانة يشتمل على تعديل الكبريت -2.4-ثنائي نيتروفينيل هيدرازين ، وتم استكشاف خصائصه المتنوعة. تم إنتاج هذه الخرسانة المبتكرة عن طريق تعديل الكبريت -2.4-ثنائي نيتروفينيل هيدرازين ومجموعة من المكونات. تم تصنيع الكبريت -2،4-دينيتروفينيل هيدرازين المعدّل والذي تم إنشاؤه حديثًا . تم فحص نسيج السطح الناتج باستخدام تقنيات SEM و .EDS تم احتساب نسب المكونات و الصفات الخرسانية والكيميائية والفيزيائية المشتقة من الكبريت -2.4-ثنائي نيتروفينيل هيدرازين المعدل ، المقاومة الكيميائية ومقاومة التآكل للخرسانة ، ثبات الخرسانة ضد امتصاص الماء ، مقاومة الخرسانة ضد التجمد ، الخصائص الفيزيائية والميكانيكية ، المتانة ، معامل المرونة ، وتم تقييم معامل التمدد الحراري للخرسانة المشبعة بالكبريت. أثبتت النتائج أن قيمة معامل التمدد الحراري للخرسانة المعدلة للكبريت -2.4-دينيتروفينيل هيدرازين كانت 14.8 × 10-6.0 درجة مئوية. كان متوسط ​​التشوه للخرسانة التي تم تحليلها 0.0026-0.0051 ، مما يشير إلى أداء تشوه متفوق مقارنة بالخرسانة التقليدية. أظهرت الخرسانة ذات الأحجام التراكمية الأصغر كثافة أكبر، 2283 كجم / م 3. تناقصت كثافة الخرسانة تدريجياً مع زيادة حجم الركام. كان ثبات الخرسانة المعدلة الكبريت -2 ، 4-دينيتروفينيل هيدرازين مرتفعًا بشكل ملحوظ في مختلف البيئات غير المناسبة . كشف تحليل EDS أن ذرات الكربون شكلت 56.63٪ من الكتلة الكلية ، بينما شكل الكبريت 33.91٪ من الكتلة الكلية. أظهرت نتائج SEM التي تم الحصول عليها أن معدل الكبريت -2.4-ثنائي نيتروفينيل هيدرازين أظهر بنية مسامية أكثر ، خالية من التكوينات البلورية. شهد تعديل الكبريت -2 ، 4-دينيتروفينيل هيدرازين خسارة الكتلة الحرارية على مرحلة واحدة ، مع فقدان الكتلة التي تكون ماصة للحرارة بطبيعتها. تحققت نتائج الأشعة تحت الحمراء من وجود مجموعات وظيفية أمينية (حلقة ميلامين متصلة) وإنشاء سلاسل كبريت بوليمر.In this investigative endeavor, a novel concrete variety incorporating sulfur-2,4-dinitrophenylhydrazine modification was developed, and its diverse attributes were explored. This innovative concrete was produced using sulfur-2,4-dinitrophenylhydrazine modification and an array of components. The newly created sulfur-2,4-dinitrophenylhydrazine modifier was synthesized. The surface texture resulting from this modifier was examined using SEM and EDS techniques. The component ratios within concrete, chemical and physical traits derived from the sulfur-2,4-dinitrophenylhydrazine modifier, chemical and corrosion resistance of concrete, concrete stability against water absorption, concrete resilience against freezing, physical and mechanical properties, durability, elastic modulus, and thermal expansion coefficient of the examined sulfur-infused concrete were assessed. The acquired results also substantiated that the thermal expansion coefficient value for sulfur-2,4-dinitrophenylhydrazine modified concrete was 14.8×10-6/0C. The average deformation of the analyzed concrete was 0.0026-0.0051, indicating a superior deformation performance compared to conventional concretes. Concrete with smaller aggregate sizes exhibited greater density, specifically 2283 kg/m3. The concrete density decreased gradually with an increase in aggregate size. The stability of sulfur-2,4-dinitrophenylhydrazine modified concrete was remarkably high in various aggressive environments. EDS analysis revealed that carbon atoms constituted 56.63% of the total mass, while sulfur made up 33.91% of the total mass. The obtained SEM outcomes demonstrated that the sulfur-2,4-dinitrophenylhydrazine modifier exhibited a more porous structure, devoid of crystalline formations. The sulfur-2,4-dinitrophenylhydrazine modification experienced a single-stage thermal mass loss, with the mass loss events being endothermic in nature. The IR findings verified the presence of amino functional groups (connected melamine ring) and the establishment of polymer sulfur chains