89 research outputs found
Threshold Effects in Multi-channel Coupling and Spectroscopic Factors in Exotic Nuclei
In the threshold region, the cross section and the associated overlap
integral obey the Wigner threshold law that results in the Wigner-cusp
phenomenon. Due to flux conservation, a cusp anomaly in one channel manifests
itself in other open channels, even if their respective thresholds appear at a
different energy. The shape of a threshold cusp depends on the orbital angular
momentum of a scattered particle; hence, studies of Wigner anomalies in weakly
bound nuclei with several low-lying thresholds can provide valuable
spectroscopic information. In this work, we investigate the threshold behavior
of spectroscopic factors in neutron-rich drip-line nuclei using the Gamow Shell
Model, which takes into account many-body correlations and the continuum
effects. The presence of threshold anomalies is demonstrated and the
implications for spectroscopic factors are discussed.Comment: Accepted in Physical Review C Figure correcte
Nuclear rupture at sites of high curvature compromises retention of DNA repair factors.
The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix-all of which sustain forces, but their relationships to DNA damage are obscure. We show that nuclear rupture with cytoplasmic mislocalization of multiple DNA repair factors correlates with high nuclear curvature imposed by an external probe or by cell attachment to either aligned collagen fibers or stiff matrix. Mislocalization is greatly enhanced by lamin A depletion, requires hours for nuclear reentry, and correlates with an increase in pan-nucleoplasmic foci of the DNA damage marker γH2AX. Excess DNA damage is rescued in ruptured nuclei by cooverexpression of multiple DNA repair factors as well as by soft matrix or inhibition of actomyosin tension. Increased contractility has the opposite effect, and stiff tumors with low lamin A indeed exhibit increased nuclear curvature, more frequent nuclear rupture, and excess DNA damage. Additional stresses likely play a role, but the data suggest high curvature promotes nuclear rupture, which compromises retention of DNA repair factors and favors sustained damage
Differential expression of the brassinosteroid receptor-encoding BRI1 gene in Arabidopsis
Abstract Brassinosteroid (BR)-regulated growth and
development in Arabidopsis depends on BRASSINOSTEROID
INSENSITIVE 1 (BRI1), the BR receptor that
is responsible for initiating the events of BR signalling.
We analysed the temporal and spatial regulation of BRI1
expression using stable transgenic lines that carried BRI1
promoter:reporter fusions. In both seedlings and mature
plants the tissues undergoing elongation or differentiation
showed elevated BRI1 gene activity, and it could be
demonstrated that in the hypocotyl this was accompanied
by accumulation of the BRI1 transcript and its receptor
protein product. In seedlings the BRI1 promoter was also
found to be under diurnal regulation, determined primarily
by light repression and a superimposed circadian control.
To determine the functional importance of transcriptional
regulation we complemented the severely BR insensitive
bri1-101 mutant with a BRI1-luciferase fusion construct
that was driven by promoters with contrasting specificities.
Whereas the BRI1 promoter-driven transgene fully restored the wild phenotype, expression from the photosynthesisassociated
CAB3 and the vasculature-specific SUC2 and
ATHB8 promoters resulted in plants with varying morphogenic
defects. Our results reveal complex differential regulation
of BRI1 expression, and suggest that by influencing
the distribution and abundance of the receptor this regulation
can enhance or attenuate BR signalling
A Comprehensive Mechanism of Fibrin Network Formation Involving Early Branching and Delayed Single- to Double-Strand Transition from Coupled Time-Resolved X-ray/Light-Scattering Detection
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Immunosuppressant-associated neurotoxicity responding to olanzapine.
Immunosuppressants, particularly tacrolimus, can induce neurotoxicity in solid organ transplantation cases. A lower clinical threshold to switch from tacrolimus to another immunosuppressant agent has been a common approach to reverse this neurotoxicity. H
Competency-based medical education and scholarship: Creating an active academic culture during residency.
The competency-based medical education movement has been adopted in several medical education systems across the world. This has the potential to result in a more active involvement of residents in the educational process, inasmuch as scholarship is regar
The role of virtual states in the appearance of two-neutron halo
The existence of loosely bound, spatially extended states in a two-particle plus core
system is studied. The description is given in the Schrödinger picture by treating
the interactions in the scattering length approximation. The treatment supports the
statement that the most favourable case for the appearance of the two-neutron halo is the
existence of large negative neutron-core scattering length (a virtual
state) besides the n-n virtual state
Immunosuppressant-Associated Neurotoxicity Responding to Olanzapine
Immunosuppressants, particularly tacrolimus, can induce neurotoxicity in solid organ transplantation cases. A lower clinical threshold to switch from tacrolimus to another immunosuppressant agent has been a common approach to reverse this neurotoxicity. However, immunosuppressant switch may place the graft at risk, and, in some cases, continuation of the same treatment protocol may be necessary. We report a case of immunosuppressant-associated neurotoxicity with prominent neuropsychiatric manifestation and describe psychiatric intervention with olanzapine that led to clinical improvement while continuing tacrolimus maintenance
Recommended from our members
Competency-based medical education and scholarship: Creating an active academic culture during residency.
The competency-based medical education movement has been adopted in several medical education systems across the world. This has the potential to result in a more active involvement of residents in the educational process, inasmuch as scholarship is regar
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