312 research outputs found
Lieb-Robinson Bounds for Harmonic and Anharmonic Lattice Systems
We prove Lieb-Robinson bounds for the dynamics of systems with an infinite
dimensional Hilbert space and generated by unbounded Hamiltonians. In
particular, we consider quantum harmonic and certain anharmonic lattice
systems
The statistical mechanics of complex signaling networks : nerve growth factor signaling
It is becoming increasingly appreciated that the signal transduction systems
used by eukaryotic cells to achieve a variety of essential responses represent
highly complex networks rather than simple linear pathways. While significant
effort is being made to experimentally measure the rate constants for
individual steps in these signaling networks, many of the parameters required
to describe the behavior of these systems remain unknown, or at best,
estimates. With these goals and caveats in mind, we use methods of statistical
mechanics to extract useful predictions for complex cellular signaling
networks. To establish the usefulness of our approach, we have applied our
methods towards modeling the nerve growth factor (NGF)-induced differentiation
of neuronal cells. Using our approach, we are able to extract predictions that
are highly specific and accurate, thereby enabling us to predict the influence
of specific signaling modules in determining the integrated cellular response
to the two growth factors. We show that extracting biologically relevant
predictions from complex signaling models appears to be possible even in the
absence of measurements of all the individual rate constants. Our methods also
raise some interesting insights into the design and possible evolution of
cellular systems, highlighting an inherent property of these systems wherein
particular ''soft'' combinations of parameters can be varied over wide ranges
without impacting the final output and demonstrating that a few ''stiff''
parameter combinations center around the paramount regulatory steps of the
network. We refer to this property -- which is distinct from robustness -- as
''sloppiness.''Comment: 24 pages, 10 EPS figures, 1 GIF (makes 5 multi-panel figs + caption
for GIF), IOP style; supp. info/figs. included as brown_supp.pd
Simulation of truncated normal variables
We provide in this paper simulation algorithms for one-sided and two-sided
truncated normal distributions. These algorithms are then used to simulate
multivariate normal variables with restricted parameter space for any
covariance structure.Comment: This 1992 paper appeared in 1995 in Statistics and Computing and the
gist of it is contained in Monte Carlo Statistical Methods (2004), but I
receive weekly requests for reprints so here it is
Isotopic characterization of nitrogen oxides (NO\u3ci\u3ex\u3c/i\u3e), nitrous acid (HONO), and nitrate (\u3ci\u3ep\u3c/i\u3eNO3-) from laboratory biomass burning during FIREX
New techniques have recently been developed and applied to capture reactive nitrogen species, including nitrogen oxides (NOx D NOCNO2), nitrous acid (HONO), nitric acid (HNO3), and particulate nitrate (pNO3 ), for accurate measurement of their isotopic composition. Here, we report – for the first time – the isotopic composition of HONO from biomass burning (BB) emissions collected during the Fire Influence on Regional to Global Environments Experiment (FIREX, later evolved into FIREX-AQ) at the Missoula Fire Science Laboratory in the fall of 2016. We used our newly developed annular denuder system (ADS), which was verified to completely capture HONO associated with BB in comparison with four other high-timeresolution concentration measurement techniques, including mist chamber–ion chromatography (MC–IC), open-path Fourier transform infrared spectroscopy (OP-FTIR), cavityenhanced spectroscopy (CES), and proton-transfer-reaction time-of-flight mass spectrometry (PTR-ToF)
Serum Galactose-Deficient IgA1 Level Is Not Associated with Proteinuria in Children with IgA Nephropathy
Introduction. Percentage of galactose-deficient IgA1 (Gd-IgA1) relative to total IgA in serum was recently reported to correlate with proteinuria at time of sampling and during follow-up for pediatric and adult patients with IgA nephropathy. We sought to determine whether this association exists in another cohort of pediatric patients with IgA nephropathy. Methods. Subjects were younger than 18 years at entry. Blood samples were collected on one or more occasions for determination of serum total IgA and Gd-IgA1. Gd-IgA1 was expressed as serum level and percent of total IgA. Urinary protein/creatinine ratio was calculated for random specimens. Spearman's correlation coefficients assessed the relationship between study variables. Results. The cohort had 29 Caucasians and 11 African-Americans with a male : female ratio of 1.9 : 1. Mean age at diagnosis was 11.7 ± 3.7 years. No statistically significant correlation was identified between serum total IgA, Gd-IgA1, or percent Gd-IgA1 versus urinary protein/creatinine ratio determined contemporaneously with biopsy or between average serum Gd-IgA1 or average percent Gd-IgA1 and time-average urinary protein/creatinine ratio. Conclusion. The magnitude of proteinuria in this cohort of pediatric patients with IgA nephropathy was influenced by factors other than Gd-IgA1 level, consistent with the proposed multi-hit pathogenetic pathways for this renal disease
Bayesian Methods for Exoplanet Science
Exoplanet research is carried out at the limits of the capabilities of
current telescopes and instruments. The studied signals are weak, and often
embedded in complex systematics from instrumental, telluric, and astrophysical
sources. Combining repeated observations of periodic events, simultaneous
observations with multiple telescopes, different observation techniques, and
existing information from theory and prior research can help to disentangle the
systematics from the planetary signals, and offers synergistic advantages over
analysing observations separately. Bayesian inference provides a
self-consistent statistical framework that addresses both the necessity for
complex systematics models, and the need to combine prior information and
heterogeneous observations. This chapter offers a brief introduction to
Bayesian inference in the context of exoplanet research, with focus on time
series analysis, and finishes with an overview of a set of freely available
programming libraries.Comment: Invited revie
Scientific Opportunities with an X-ray Free-Electron Laser Oscillator
An X-ray free-electron laser oscillator (XFELO) is a new type of hard X-ray
source that would produce fully coherent pulses with meV bandwidth and stable
intensity. The XFELO complements existing sources based on self-amplified
spontaneous emission (SASE) from high-gain X-ray free-electron lasers (XFEL)
that produce ultra-short pulses with broad-band chaotic spectra. This report is
based on discussions of scientific opportunities enabled by an XFELO during a
workshop held at SLAC on June 29 - July 1, 2016Comment: 21 pages, 12 figure
Plasma Dynamics
Contains reports on ten research projects divided into two sections.National Science Foundation (Grant ENG79-07047)U.S. Air Force - Office of Scientific Research (Grant AFOSR-77-3143)U.S. Department of Energy (Contract DE-ACO2-78ET51013)U.S. Department of Energy (Contract DE-ASO2-78ET53073.AO02)U.S. Department of Energy (Contract ET-78-S-02-4682)U.S. Department of Energy (Contract DE-AS02-78ET53074)U.S. Department of Energy (Contract DE-ASO2-78ET53050)U.S. Department of Energy (Contract DE-AS02-78ET51002)U.S. Department of Energy (Contract DE-ASO2-78ET53076
Structure-based classification and ontology in chemistry
<p>Abstract</p> <p>Background</p> <p>Recent years have seen an explosion in the availability of data in the chemistry domain. With this information explosion, however, retrieving <it>relevant </it>results from the available information, and <it>organising </it>those results, become even harder problems. Computational processing is essential to filter and organise the available resources so as to better facilitate the work of scientists. Ontologies encode expert domain knowledge in a hierarchically organised machine-processable format. One such ontology for the chemical domain is ChEBI. ChEBI provides a classification of chemicals based on their structural features and a role or activity-based classification. An example of a structure-based class is 'pentacyclic compound' (compounds containing five-ring structures), while an example of a role-based class is 'analgesic', since many different chemicals can act as analgesics without sharing structural features. Structure-based classification in chemistry exploits elegant regularities and symmetries in the underlying chemical domain. As yet, there has been neither a systematic analysis of the types of structural classification in use in chemistry nor a comparison to the capabilities of available technologies.</p> <p>Results</p> <p>We analyze the different categories of structural classes in chemistry, presenting a list of patterns for features found in class definitions. We compare these patterns of class definition to tools which allow for automation of hierarchy construction within cheminformatics and within logic-based ontology technology, going into detail in the latter case with respect to the expressive capabilities of the Web Ontology Language and recent extensions for modelling structured objects. Finally we discuss the relationships and interactions between cheminformatics approaches and logic-based approaches.</p> <p>Conclusion</p> <p>Systems that perform intelligent reasoning tasks on chemistry data require a diverse set of underlying computational utilities including algorithmic, statistical and logic-based tools. For the task of automatic structure-based classification of chemical entities, essential to managing the vast swathes of chemical data being brought online, systems which are capable of hybrid reasoning combining several different approaches are crucial. We provide a thorough review of the available tools and methodologies, and identify areas of open research.</p
Highly Unsaturated Fatty Acid Synthesis in Atlantic Salmon: Characterization of ELOVL5- and ELOVL2-like Elongases
Fish species vary in their capacity to biosynthesize the n-3 long-chain polyunsaturated fatty acids (LC-PUFA) eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids that are crucial to the health of higher vertebrates. The synthesis of LC-PUFA involves enzyme-mediated fatty acyl desaturation and elongation. Previously, a cDNA for an elongase, now termed elovl5a, had been cloned from Atlantic salmon. Here we report on the cloning of two new elongase cDNAs: a second elovl5b elongase, corresponding to a 294 aa protein, and an elovl2-like elongase, coding for a 287 aa protein, characterized for the first time in a non-mammalian vertebrate. Heterologous expression in yeast showed that the salmon Elovl5b elongated C18 and C20 PUFA, with low activity towards C22, while Elovl2 elongated C20 and C22 PUFA with lower activity towards C18 PUFA. All three transcripts showed predominant expression in the intestine and liver, followed by the brain. Elongase expression showed differential nutritional regulation. Levels of elovl5b and particularly of elovl2, but not of elovl5a, transcripts were significantly increased in liver of salmon fed vegetable oils (VO) compared to fish fed fish oil (FO). Intestinal expression showed a similar pattern. Phylogenetic comparisons indicate that, in contrast to salmon and zebrafish, Acanthopterygian fish species lack elovl2 which is consistent with their neglible ability to biosynthesise LC-PUFA and to adapt to VO dietary inclusion, compared to predominantly freshwater salmonids. Thus the presence of elovl2 in salmon explains the ability of this species to biosynthesise LC-HUFA and may provide a biotechnological tool to produce enhanced levels of LC-PUFA, particularly DHA, in transgenic organisms
- …