m6A mRNA Methylation: A New Circadian Pacesetter

The purpose of m6A methylation of RNA, first observed in the 1970s, has been a longstanding mystery. Fustin et al. now show that it regulates RNA processing and determines the period and oscillatory stability of the mammalian circadian clockwork

Hibernation Proteins: Preparing for Life in the Freezer

Hibernation is an extreme response to a seasonal environment, yet we know almost nothing about how it is timed or how vital cellular functions are sustained in the face of plummeting body temperature. In this issue of Cell, Kondo et al. (2006) identify a liver-derived protein complex as an essential coordinator of this adaptation to the depredations of winter

Area laws in quantum systems: mutual information and correlations

The holographic principle states that on a fundamental level the information content of a region should depend on its surface area rather than on its volume. This counterintuitive idea which has its roots in the nonextensive nature of black-hole entropy serves as a guiding principle in the search for the fundamental laws of Planck-scale physics. In this paper we show that a similar phenomenon emerges from the established laws of classical and quantum physics: the information contained in part of a system in thermal equilibrium obeys an area law. While the maximal information per unit area depends classically only on the number of microscopic degrees of freedom, it may diverge as the inverse temperature in quantum systems. A rigorous relation between area laws and correlations is established and their explicit behavior is revealed for a large class of quantum many-body states beyond equilibrium systems.Comment: 5 pages, 2 figures, published version with appendi

Impact of foot progression angle modification on plantar loading in individuals with diabetes mellitus and peripheral neuropathy

AIMS: To determine if participants can reduce foot progression angle (FPA), and if FPA reduction decreases regional plantar stresses and forces in individuals with diabetes. METHODS: DESIGN: Three-group cross-sectional design with repeated measures. SUBJECTS: twenty-eight participants either with diabetes mellitus (DM), diabetes and peripheral neuropathy with (DMPN+NPU) or without a prior history of ulceration (DMPN−NPU) were studied. INTERVENTION: Participants were first instructed to walk over a 3.6 m walkway at their preferred FPA, and then to walk with their foot aligned parallel with the line of gait progression at their self-selected speed. Dynamic plantar kinetics in six masked regions were collected using an EMED-st-P-2 pedobarograph. MAIN MEASURES: Primary outcome measures were FPA, peak plantar pressure (PPP), and force-time integral (FTI). A repeated measures ANOVA was conducted to determine group differences in FPA for both walking conditions. Regional differences in PPPs and FTIs between preferred and corrected walking conditions were analyzed using repeated measures ANCOVA. RESULTS: Participants showed a reduction in FPA magnitude on the ‘Involved’ foot between the preferred and corrected walking conditions (p<0.01). There were no differences in PPPs or FTIs in any mask between walking conditions (p>0.05). CONCLUSION: Results from this investigation offer important evidence that people with diabetes can modify their FPA with a simple intervention of visual and verbal cueing. Future research should examine if gait retraining strategies in regular footwear more effectively offload areas of elevated regional plantar stresses and forces in adults with diabetes mellitus and peripheral neuropathy

Controlling Change Within Complex Systems Through Pliability

As systems become larger, more complex, and operate for longer periods of time, some change within the system often becomes inevitable. Particularly in systems of systems, with diverse stakeholders, evolutionary development and managerial independence, it is not unusual for constituent systems to change in form or the way they operate. Changeability, the ability of a system to change, is often considered to be a desirable attribute that allows systems to be robust and to adapt in response to changes in context. However, involuntary changes, such as those that occur as a result of a disturbance, are more often problematic than favorable. In some ways, the survivability of a system depends on its ability to prevent, mitigate and recover from unintentional changes within the system brought about by disturbances. For certain large systems of systems, where there are complex interactions and a diverse set of stakeholders, even voluntary changes may be frowned upon, since it may be an expensive and time consuming process to approve changes. This paper discusses pliability, a new “-ility” that places constraints on the changes a system is allowed to make. Pliability is the ability of a system to change, without “breaking” or violating an architecture that the system architects intended and validated. Like changeability, pliability increases robustness by allowing systems to voluntarily change in response to changing contexts, and increases survivability by increasing the likelihood that unintentional changes are still within the set of allowable instances. It also distinguishes allowable changes from those that would require validation and approval from decision makers, making it easier to actually implement those changes in large, complex systems

A taxonomy of perturbations: Determining the ways that systems lose value

Disturbances and disruptions, both internal and external to the system, are a major concern for system architects who are responsible for ensuring that their systems maintain value robustness no matter what occurs. These perturbations can have multiple causes and can affect a system in multiple ways. This paper presents a taxonomy of disturbances and disruptions to assist system architects and researchers in identifying the ways in which systems can fail to deliver value. By doing so, this taxonomy falls into a larger research effort to develop survivability design principles that will help system architects design systems that prevent, mitigate and recover from disturbances

Investigating alternative concepts of operations for a maritime security system of systems

For complex systems of systems, such as those required to perform maritime security, system architects have numerous choices they may select from, both in the components and in the way the system operates. Component choices, such as the length of a wing or the number of ground control stations, are often considered in tradespace studies, but this paper highlights the operational choices that are often overlooked. Using an unmanned vehicle system of systems as an example, the importance of considering operational choices as well as the highly interdependent nature of operational and component choices is demonstrated, further strengthening the case for careful consideration of operational variables early in the concept phase of the design process. Finally, a high-level methodology for generating and evaluating operational choices is introduced

Revisiting the Question: Are Systems of Systems just (traditional) Systems or are they a new class of Systems?

This paper revisits a question asked and debated widely over the past decade: are Systems of Systems (SoS) just traditional systems or are they a new class of systems? Many have argued that SoS are a new class of systems, but little research has been available to provide evidence of this. In this paper we share highlights of recent research to show SoS not only have a different structure than systems and thus need to be engineered differently, but also may possess different attributes for beyond first use properties (the “illities”) such as flexibility and adaptability as compared to systems. By examining historical examples and by using a maritime security SoS as a research test bed, this paper shows that the “ility” called survivability had some design strategies that were directly mapped from systems and also allowed new strategies that only made sense for a SoS (e.g. vigilance). The paper also shows that some design strategies have a different implementation and meaning (e.g. margin) at the level of a system compared to SoS level. We conclude the answer to the question “Are SoS’s just systems?” is both yes and no. They are manifestly systems but possess properties not found in traditional systems. This is shown to true of the meta-property of survivability as applied against a directed SoS