Coulomb-assisted braiding of Majorana fermions in a Josephson junction array

We show how to exchange (braid) Majorana fermions in a network of superconducting nanowires by control over Coulomb interactions rather than tunneling. Even though Majorana fermions are charge-neutral quasiparticles (equal to their own antiparticle), they have an effective long-range interaction through the even-odd electron number dependence of the superconducting ground state. The flux through a split Josephson junction controls this interaction via the ratio of Josephson and charging energies, with exponential sensitivity. By switching the interaction on and off in neighboring segments of a Josephson junction array, the non-Abelian braiding statistics can be realized without the need to control tunnel couplings by gate electrodes. This is a solution to the problem how to operate on topological qubits when gate voltages are screened by the superconductor

Global distribution of total ozone and lower stratospheric temperature variations

International audienceThis study gives an overview of interannual variations of total ozone and 50 hPa temperature. It is based on newer and longer records from the 1979 to 2001 Total Ozone Monitoring Spectrometer (TOMS) and Solar Backscatter Ultraviolet (SBUV) instruments, and on US National Center for Environmental Prediction (NCEP) reanalyses. Multiple linear least squares regression is used to attribute variations to various natural and anthropogenic explanatory variables. Usually, maps of total ozone and 50 hPa temperature variations look very similar, reflecting a very close coupling between the two. As a rule of thumb, a 10 Dobson Unit (DU) change in total ozone corresponds to a 1 K change of 50 hPa temperature. Large variations come from the linear trend term, up to -30 DU or -1.5 K/decade, from terms related to polar vortex strength, up to 50 DU or 5 K (typical, minimum to maximum), from tropospheric meteorology, up to 30 DU or 3 K, or from the Quasi-Biennial Oscillation (QBO), up to 25 DU or 2.5 K. The 11-year solar cycle, up to 25 DU or 2.5 K, or El Niño/Southern Oscillation (ENSO), up to 10 DU or 1 K, are contributing smaller variations. Stratospheric aerosol after the 1991 Pinatubo eruption lead to warming up to 3 K at low latitudes and to ozone depletion up to 40 DU at high latitudes. Variations attributed to QBO, polar vortex strength, and to a lesser degree to ENSO, exhibit an inverse correlation between low latitudes and higher latitudes. Variations related to the solar cycle or 400 hPa temperature, however, have the same sign over most of the globe. Variations are usually zonally symmetric at low and mid-latitudes, but asymmetric at high latitudes. There, position and strength of the stratospheric anti-cyclones over the Aleutians and south of Australia appear to vary with the phases of solar cycle, QBO or ENSO

Primary Prevention of First-Ever Stroke in Primary Health Care: A Clinical Practice Study Based on Medical Register Data in Sweden

Background. The aim of this study was to investigate whether established risk factors for stroke in patients admitted to health care for first-ever stroke had been detected and treated in primary health care. Methods. In a retrospective study in Nacka municipality, Stockholm County, Sweden, with about 70 000 inhabitants, we included all men and women admitted to health care due to first-ever stroke between October 1999 and March 2001. Data on 187 such patients, with a mean age of 75 years, were obtained from medical registers. Main outcome measures were detection and treatment of risk factors for stroke including hypertension, diabetes, atrial fibrillation, smoking, alcohol abuse, and overweight/obesity. Results. In a majority of patients seen in primary health care with hypertension and diabetes, those risk factors were detected and treated (75.6% and 75.0%, resp.). Fewer patients with atrial fibrillation received treatment (60.9%). Treatment of lifestyle factors was difficult to assess because of lack of data in the medical records. Conclusions. Primary prevention of stroke in primary health care needs to be improved, especially when atrial fibrillation and lifestyle-related risk factors are present. Health policies need to target not only the public, but also general practitioners and other health care professionals

Investigation of mass flows in the transition region and corona in a three-dimensional numerical model approach

The origin of solar transition region redshifts is not completely understood. Current research is addressing this issue by investigating three-dimensional magneto-hydrodynamic models that extend from the photosphere to the corona. By studying the average properties of emission line profiles synthesized from the simulation runs and comparing them to observations with present-day instrumentation, we investigate the origin of mass flows in the solar transition region and corona. Doppler shifts were determined from the emission line profiles of various extreme-ultraviolet emission lines formed in the range of $T=10^4-10^6$ K. Plasma velocities and mass flows were investigated for their contribution to the observed Doppler shifts in the model. In particular, the temporal evolution of plasma flows along the magnetic field lines was analyzed. Comparing observed vs. modeled Doppler shifts shows a good correlation in the temperature range $\log(T$/[K])=4.5-5.7, which is the basis of our search for the origin of the line shifts. The vertical velocity obtained when weighting the velocity by the density squared is shown to be almost identical to the corresponding Doppler shift. Therefore, a direct comparison between Doppler shifts and the model parameters is allowed. A simple interpretation of Doppler shifts in terms of mass flux leads to overestimating the mass flux. Upflows in the model appear in the form of cool pockets of gas that heat up slowly as they rise. Their low temperature means that these pockets are not observed as blueshifts in the transition region and coronal lines. For a set of magnetic field lines, two different flow phases could be identified. The coronal part of the field line is intermittently connected to subjacent layers of either strong or weak heating, leading either to mass flows into the loop or to the draining of the loop.Comment: 7 pages, 7 figure

The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β -cells

Diabetes is an epidemic of worldwide proportions caused by β -cell failure. Nutrient fluctuations and insulin resistance drive β -cells to synthesize insulin beyond their capacity for protein folding and secretion and thereby activate the unfolded protein response (UPR), an adaptive signalling pathway to promote cell survival upon accumulation of unfolded protein in the endoplasmic reticulum (ER). Protein kinase-like endoplasmic reticulum kinase (PERK) signals one component of the UPR through phosphorylation of eukaryotic initiation factor 2 on the α -subunit (eIF2 α ) to attenuate protein synthesis, thereby reducing the biosynthetic burden. β -Cells uniquely require PERK-mediated phosphorylation of eIF2 α to preserve cell function. Unabated protein synthesis in β -cells is sufficient to initiate a cascade of events, including oxidative stress, that are characteristic of β -cell failure observed in type 2 diabetes. In contrast to acute adaptive UPR activation, chronic activation increases expression of the proapoptotic transcription factor CAAT/enhancer-binding protein homologous protein (CHOP). Chop deletion in insulin-resistant mice profoundly increases β -cell mass and prevents β -cell failure to forestall the progression of diabetes. The findings suggest an unprecedented link by which protein synthesis and/or misfolding in the ER causes oxidative stress and should encourage the development of novel strategies to treat diabetes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/79390/1/j.1463-1326.2010.01281.x.pd

What is known about the health and living conditions of the indigenous people of northern Scandinavia, the Sami?

The Sami are the indigenous ethnic population of northern Scandinavia. Their health condition is poorly known, although the knowledge has improved over the last decade.The aim was to review the current information on mortality, diseases, and risk factor exposure in the Swedish Sami population.Health-related research on Sami cohorts published in scientific journals and anthologies was used to compare the health condition among the Sami and the majority non-Sami population. When relevant, data from the Sami populations in Swedish were compared with corresponding data from Norwegian and Finnish Sami populations.Life expectancy and mortality patterns of the Sami are similar to those of the majority population. Small differences in incidences of cancer and cardiovascular diseases have been reported. The traditional Sami lifestyle seems to contain elements that reduce the risk to develop cancer and cardiovascular diseases, e.g. physical activity, diet rich in antioxidants and unsaturated fatty acids, and a strong cultural identity. Reindeer herding is an important cultural activity among the Sami and is associated with high risks for accidents. Pain in the lower back, neck, shoulders, elbows, and hands are frequent among both men and women in reindeer-herding families. For men, these symptoms are related to high exposure to terrain vehicles, particularly snowmobile, whereas for women psychosocial risk factors seem to more important, e.g. poor social support, high effort, low reward, and high economical responsibilities.Although the health condition of the Sami population appears to be rather similar to that of the general Swedish population, a number of specific health problems have been identified, especially among the reindeer-herding Sami. Most of these problems have their origin in marginalization and poor knowledge of the reindeer husbandry and the Sami culture in the majority population. It is suggested that the most sustainable measure to improve the health among the reindeer-herding Sami would be to improve the conditions of the reindeer husbandry and the Sami culture

Tetra­carbon­yl[bis­(diphenyl­phosphan­yl)tetra­methyl­disiloxane-κ2 P,P′]chromium(0)

The title compound, [Cr(C28H32OP2Si2)(CO)4], was obtained by the ligand-exchange reaction of Cr(CO)6 with (Ph2PSiMe2)2O in refluxing toluene. The CrC4P2 coordination geometry is distorted octa­hedral, with a P—Cr—P bite angle of 99.22 (4)°

Modeling the variations of Dose Rate measured by RAD during the first MSL Martian year: 2012-2014

The Radiation Assessment Detector (RAD), on board Mars Science Laboratory's (MSL) rover Curiosity, measures the {energy spectra} of both energetic charged and neutral particles along with the radiation dose rate at the surface of Mars. With these first-ever measurements on the Martian surface, RAD observed several effects influencing the galactic cosmic ray (GCR) induced surface radiation dose concurrently: [a] short-term diurnal variations of the Martian atmospheric pressure caused by daily thermal tides, [b] long-term seasonal pressure changes in the Martian atmosphere, and [c] the modulation of the primary GCR flux by the heliospheric magnetic field, which correlates with long-term solar activity and the rotation of the Sun. The RAD surface dose measurements, along with the surface pressure data and the solar modulation factor, are analysed and fitted to empirical models which quantitatively demonstrate} how the long-term influences ([b] and [c]) are related to the measured dose rates. {Correspondingly we can estimate dose rate and dose equivalents under different solar modulations and different atmospheric conditions, thus allowing empirical predictions of the Martian surface radiation environment