Novel Oral Anticoagulants for Venous Thromboembolism with Special Emphasis on Risk of Hemorrhagic Complications and Reversal Agents

Osnovni cilj istraživanja završnog rada bio je ispitati empatiju, prosocijalno ponašanje i samoregulaciju studentica koje se osposobljavaju za rad s djecom predškolske dobi. To može biti pokazatelj u kojoj su mjeri kod njih razvijene kompetencije empatiziranja s osobama u njihovom okruženju, prepoznavanja i razumijevanja tuđih emocija, moralno rasuđivanje i postupci te regulacija vlastitih emocija i ponašanja. Istraživanje je provedeno na uzorku od 58 studentica predškolskog odgoja. Iako ne u svim dimenzijama, studentice su kod većine pokazale viši stupanj razvoja empatije te srednje razvijeno prosocijalno ponašanje i samoregulaciju. Također, pokazala se i značajna pozitivna povezanost među nekim dimenzijama ovih kompetencija. Biti odgojiteljica izrazito je izazovan profesionalni zadatak. Odgojiteljica koja se trudi biti uspješna u svojem zadatku, osim što treba biti usmjerena na odgojno-obrazovni aspekt za poticanje razvoja djeteta, također treba biti vrlo svjesna sebe, svojih emocionalnih stanja i kapaciteta, svojih komunikacijskih obrazaca, kako s djecom, tako i s roditeljima i kolegicama i kolegama na poslu te načina postavljanja granica u ponašanju djece. To nužno uvjetuje stalno profesionalno usavršavanje i stalni rad na sebi. Radom na sebi i povećanjem razvoja vlastitih sposobnosti utjecat ćemo na pozitivan rast i razvoj socioemocionalnih kompetencija djece.The main purpose in this research was to explore empathy, prosocial behaviour and self-regulation of students who are trained to work in nursery and kindergarten. It can be a predictor of how well they have developed competencies of empathizing with people in their environment, recognizing and understanding other people’s emotions, making moral judgments and actions and regulation of their own emotions and behaviour. The research was conducted on a sample of 58 university students. Although not in all dimensions, students showed higher developed empathy, and moderately developed prosocial behaviour and self-regulation. There is, also, a significant positive correlation between certain dimensions of these competences. Being a nursery and kindergarten teacher is a very challenging profession. The teachers that are trying to be successful in their work, in addition to being focused on the educational aspect of child development, also need to be very aware of themselves, their emotional states and capacities, communication skills with children, parents and colleagues at work and the ways to set boundaries in children's behaviour. This necessarily requires constant professional development and constant work on themselves. By working on themselves and enhancing the development of the own abilities, they will influence the positive growth and development of children's socio-emotional competences

Cold snare endoscopic resection of nonpedunculated colorectal polyps larger than 10 mm: a systematic review and pooled-analysis

Background and Aims: Hot snare polypectomy and EMR are the standard of care in resecting colorectal polyps 6510 mm. To avoid the risk of electrocautery-induced damage, there is recent evidence about using cold snare polypectomy and cold EMR for such lesions. The aim of this pooled analysis is to report outcomes of cold snare resection for polyps 6510 mm. Methods: PubMed/Medline, Embase, Google Scholar, and Cochrane databases were searched up to July 2018 to identify studies that performed cold snare resection for colorectal polyps 6510 mm. Primary outcomes were adverse events (bleeding, perforation, and postpolypectomy abdominal pain), and secondary outcomes were the rates of complete resection, overall residual polyp rates, and rates for adenomas versus sessile serrated polyps (SSPs). Subgroup analysis was performed focusing on lesion size, location, and resection technique. Results: Eight studies were included in the final analysis that included 522 colorectal polyps with a mean polyp size of 17.5 mm (range, 10-60). The overall adverse event rate was 1.1% (95% confidence interval, CI, 0.2%-2.0%; I 2 = 0%). Intra- and postprocedural bleeding rates were.7% (95% CI, 0%-1.4%) and.5% (95% CI,.1%-1.2%), respectively, with abdominal pain rate being.6% (95% CI,.1%-1.3%). Polyps 6520 mm had a higher intraprocedural bleeding rate of 1.3% (95% CI,.7%-3.3%) and abdominal pain rate of 1.2% (95% CI,.7%-3.0%) but no delayed bleedings. No perforations were reported. The complete resection rate was 99.3% (95% CI, 98.6%-100%). Overall pooled residual rates of polyps of any histology, adenomas, and SSPs were 4.1% (95% CI,.2%-8.4%), 11.1% (95% CI, 4.1%-18.1%), and 1.0% (95% CI,.4%-2.4%), respectively, during a follow-up period ranging from 154 to 258 days. Conclusions: The results of this systematic review and pooled analysis were excellent with cold snare resection of colorectal polyps >10 mm in terms of postpolypectomy bleeding, complete resection, and residual polyp rates. Randomized controlled trials comparing cold snare resection with hot snare resections of polyps 6510 mm are required for further investigation