18,836 research outputs found

    LEVERAGING SOA IN BANKING SYSTEMS INTEGRATION

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    There is no doubt that the systems integration is one of the most important and complicated tasks in software filed especially for complex applications like banking systems. Complexity in integrating banking systems often comes from continues changes in both technical and business features provided by them to meet customer needs. Banking systems always come from different software vendors which mean using platforms and different design and architecture patterns, and this for sure adds extra complexity for integrating them. Serviceoriented architecture (SOA) is a promising method in software filed that aims to build or restructure software systems in a manner that makes their maintenance and integration easier. Agility is the most important goal that should be achieved when building and integrating banking systems. Simply, agility is needed to meet market needs quickly and efficiently and SOA is the way that could provide itSOA, SOI, P2P Integration, Web Services, and Legacy Code

    Non-Linear Massive Gravity with Additional Primary Constraint and Absence of Ghosts

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    We complete the Hamiltonian analysis of specific model of non-linear massive gravity that was started in arXiv:1112.5267. We identify the primary constraint and corresponding secondary constraint. We show that they are the second class constraints and hence they lead to the elimination of the additional scalar mode. We also find that the remaining constraints are the first class constraints with the structure that corresponds to the manifestly diffeomorphism invariant theory. Finally we determine the number of physical degrees of freedom and we show that it corresponds to the number of physical modes of massive gravity.Comment: 13 page

    Dual Induction of New Microbial Secondary Metabolites by Fungal Bacterial Co-cultivation

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    We thank the College of Physical Sciences, University of Aberdeen, for provision of infrastructure and facilities in the Marine Biodiscovery Centre. We acknowledge the receipt of funding from the European Union’s Seventh Programme for Research, Technological Development and Demonstration under Grant Agreement No. 312184 (PharmaSea). MR thanks School of Science and Sport, University of the West of Scotland for providing the open-access fees required for the publication.Peer reviewedPublisher PD

    Is Low Alveolar Type II Cell SOD3 in the Lungs of Elderly Linked to the Observed Severity of COVID-19?

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    Human lungs single cell RNA sequencing data from healthy donors (elderly and young; GEO accession number GSE122960) were analyzed to isolate and specifically study gene expression in alveolar type II cells. Co-localization of ACE2 and TMPRSS2 enables SARS-CoV 2 to enter the cells. Expression of these genes in the alveolar type II cells of elderly and young patients were comparable and therefore do not seem to be responsible for worse outcomes observed in COVID-19 affected elderly. In cells from the elderly, 263 genes were downregulated and 95 upregulated. SOD3 was identified as the top-ranked gene that was most down-regulated in the elderly. Other redox-active genes that were also downregulated in cells from the elderly included ATF4 and M2TA. ATF4, an ER stress sensor that defends lungs via induction of heme oxygenase 1. The study of downstream factors known to be induced by ATF4, according to Ingenuity Pathway AnalysisTM, identified 24 candidates. Twenty-one of these were significantly downregulated in the cells from the elderly. These downregulated candidates were subjected to enrichment using the Reactome Database identifying that in the elderly, the ability to respond to heme deficiency and the ATF4-dependent ability to respond to endoplasmic reticulum stress is significantly compromised. SOD3-based therapeutic strategies have provided beneficial results in treating lung disorders including fibrosis. The findings of this work propose the hypotheses that lung-specific delivery of SOD3/ATF4 related antioxidants may work in synergy with promising anti-viral drugs such as remdesivir to further improve COVID-19 outcomes in the elderly

    Cosmological solutions of massive gravity on de Sitter

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    In the framework of the recently proposed models of massive gravity, defined with respect to a de Sitter reference metric, we obtain new homogeneous and isotropic solutions for arbitrary cosmological matter and arbitrary spatial curvature. These solutions can be classified into three branches. In the first two, the massive gravity terms behave like a cosmological constant. In the third branch, the massive gravity effects can be described by a time evolving effective fluid with rather remarkable features, including the property to behave as a cosmological constant at late time.Comment: 6 pages, 1 figure; discussion extended, a few references added, improved analysis in Section
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