Bonifacio – Licetto, Monte Leone (parcelles K421, K426, K437, K438, K719, K720)

Le diagnostic archéologique de Licetto et Monte Leone s’est avéré négatif malgré un contexte potentiellement favorable, les terrains surplombant directement l’abri du Monte Leone, site majeur pour la compréhension du peuplement mésolithique de la Corse. L’ouverture de cinquante tranchées dans les espaces accessibles du terrain n’a livré aucune trace d’occupation préhistorique, hormis la présence de deux tessons de céramique non tournée isolés. Il est vrai que la stratigraphie est remarquablem..

The Online Terminology Forum for East Cree and Innu: A collaborative approach to multi-format terminology development

For Indigenous languages to thrive, it is essential for speakers to be able to talk about their present reality in relevant and meaningful ways. In this paper, we report on our work in terminology development through workshops and the creation and use of modern digital tools including online dictionaries and terminology forums, and by working with speakers in the creation and ongoing discussion of new words. We describe the technology required to make this possible and the necessity of producing various formats, such as interactive images, booklets, and multimedia apps. We dis-cuss the tools we have developed with and for East Cree and Innu speakers, transla-tors, and linguists and the challenges of quality terminology creation, including con-text, clarity, dialectal variation, multiple submissions, and the specificity of the struc-ture of Algonquian languages. We explain how videos can complement and support terminology development and diffusion and the importance of providing searchable, translated texts for models and context. We stress the importance of allowing oral, visual, and written submissions to interactive terminology databases. We also report on two Online Terminology Forum training workshops with Innu translators. We demonstrate the advantages of building a pan-Algonquian terminology database to combine, strengthen, and expand communities’ (re)vitalization efforts across thematic domains such as health, justice, environment, education, and technology.National Foreign Language Resource Cente

Nîmes – ZAC du Mas des Abeilles

Date de l'opération : 1997 (SD) ; 1998 (SD) ; 1998 (SP) Inventeur(s) : Sauvage Laurent (AFAN) ; Escallon Gilles (AFAN) ; Hasler Anne (AFAN) Plan général des opérations extra muros de Nîmes (Fig. n°1 : Plan général des principales opérations rurales (1991-1998)). L’aménagement de la ZAC du mas des Abeilles fait l’objet, depuis 1997, d’un suivi archéologique systématique qui a conduit à la réalisation d’une série d’interventions archéologiques, sous forme de diagnostics en tranchée (mas des Ab..

Long-Term Clinical and Multimodal Imaging Findings in Patients with Disseminated Mycobacterium Chimaera Infection

BACKGROUND To analyze long-term ophthalmic clinical and multimodal imaging findings of disseminated Mycobacterium (M.) chimaera infection after cardiothoracic surgery among the Swiss Cohort. METHODS Systemic and multimodal ophthalmic imaging and clinical findings including rate of recurrence were reviewed and correlated to a previously proposed classification system of choroidal lesions and classification of ocular disease. MAIN OUTCOMES MEASURES long-term clinical and multimodal ocular imaging findings of M. chimaera. RESULTS Twelve patients suffering from systemic infection from M. chimaera were included. Mean age at the first ophthalmic examination was 59 years (range from 48 to 66 years). Mean duration of the follow-up was 22.63 ± 17.8 months. All patients presented with bilateral chorioretinal lesions at baseline; 5 patients had additional signs, including optic disc swelling (2), choroidal neovascularization (1), retinal neovascularization (1) and cilioretinal vascular occlusion (1). Four recurrence events after discontinuation or adjustment of the antibiotic treatment were observed. Progressive choroiditis was seen in 5 patients under treatment, 4 of them deceased. CONCLUSIONS Expertise from ophthalmologists is not only relevant but also critical for the assessment of the adverse drug effect of antimycobacterial treatment along with monitoring therapeutic response and identifying recurrences

Témoignage d’une crise de mortalité au Chasséen ancien : la sépulture en puits de Manduel (Gard)

Des restes humains ont été découverts dans la partie inférieure d’un puits du Néolithique moyen chasséen lors de la fouille du site de Fumerian (resp. A. Hasler, Inrap) à Manduel près de Nîmes dans le Gard. Ces restes squelettiques se rapportent à huit individus, trois adultes et cinq sujets immatures, qui ont été inhumés à l’état de cadavres frais dans un laps de temps relativement court. Les questions qui se posent pour ce dépôt inhabituel sont de plusieurs ordres. Elles concernent, d’une part, des aspects biologiques liés au recrutement et au profil de mortalité des inhumés et, d’autre part, des aspects archéologiques relatifs au caractère sépulcral ou non de la gestion de ces décès rapprochés.Human remains were discovered in the lower part of a Middle Neolithic I Chassean well during an excavation (INRAP) at the site of Fumerian-Manduel near Nimes (Gard, France). These skeletal remains belong to eight individuals, three adults and five subadults, who were buried as fresh corpses in a relatively short lapse of time. This unusual deposit gives rise to questions of various kinds, which include, on the one hand, biological aspects related to the recruitment and mortality profile of the buried individuals and, on the other hand, archaeological aspects concerned with the funerary nature – or otherwise - of the handling of these deaths that occurred close together in time

Adult attention deficit hyperactivity disorder is associated with asthma

<p>Abstract</p> <p>Background</p> <p>Attention deficit hyperactivity disorder (ADHD) is increasingly recognized as a common disorder not only in children, but also in the adult population. Similarly, asthma also has a substantial prevalence among adults. Previous studies concerning a potential relationship between ADHD and asthma have not presented consistent results.</p> <p>Methods</p> <p>A cross-sectional study of 594 adult patients diagnosed with ADHD, compared with 719 persons from the general population. Information was collected between 1997 and 2005 using auto-questionnaires rating past and present symptoms of ADHD, co-morbid conditions, including asthma, and work status.</p> <p>Results</p> <p>The prevalence of asthma was significantly higher in the ADHD patient group compared to the controls, 24.4% vs. 11.3% respectively (OR = 2.54, 95% CI 1.89-3.44), and controls with asthma scored higher on ratings of both past and present symptoms of ADHD. Female ADHD patients had a significantly higher prevalence of asthma compared to male ADHD patients (30.9% vs. 18.2%, OR = 2.01, CI 1.36-2.95), but in controls a slight female preponderance was not statistically significant. In both ADHD patients and controls, having asthma was associated with an increased prevalence of symptoms of mood- and anxiety disorders.</p> <p>Conclusions</p> <p>The present findings point to a co-morbidity of ADHD and asthma, and these patients may represent a clinical and biological subgroup of adult patients with ADHD.</p

Diverse Splicing Patterns of Exonized Alu Elements in Human Tissues

Exonization of Alu elements is a major mechanism for birth of new exons in primate genomes. Prior analyses of expressed sequence tags show that almost all Alu-derived exons are alternatively spliced, and the vast majority of these exons have low transcript inclusion levels. In this work, we provide genomic and experimental evidence for diverse splicing patterns of exonized Alu elements in human tissues. Using Exon array data of 330 Alu-derived exons in 11 human tissues and detailed RT-PCR analyses of 38 exons, we show that some Alu-derived exons are constitutively spliced in a broad range of human tissues, and some display strong tissue-specific switch in their transcript inclusion levels. Most of such exons are derived from ancient Alu elements in the genome. In SEPN1, mutations of which are linked to a form of congenital muscular dystrophy, the muscle-specific inclusion of an Alu-derived exon may be important for regulating SEPN1 activity in muscle. Realtime qPCR analysis of this SEPN1 exon in macaque and chimpanzee tissues indicates human-specific increase in its transcript inclusion level and muscle specificity after the divergence of humans and chimpanzees. Our results imply that some Alu exonization events may have acquired adaptive benefits during the evolution of primate transcriptomes