Getting Ahead or Losing Ground: Economic Mobility in America

Combines earlier research to present a comprehensive analysis of relative mobility, absolute mobility, and changes in income inequality. Focuses on intergenerational mobility, immigrants, comparisons by gender and race, and the role of education

Kinks in dipole chains

It is shown that the topological discrete sine-Gordon system introduced by Speight and Ward models the dynamics of an infinite uniform chain of electric dipoles constrained to rotate in a plane containing the chain. Such a chain admits a novel type of static kink solution which may occupy any position relative to the spatial lattice and experiences no Peierls-Nabarro barrier. Consequently the dynamics of a single kink is highly continuum like, despite the strongly discrete nature of the model. Static multikinks and kink-antikink pairs are constructed, and it is shown that all such static solutions are unstable. Exact propagating kinks are sought numerically using the pseudo-spectral method, but it is found that none exist, except, perhaps, at very low speed.Comment: Published version. 21 pages, 5 figures. Section 3 completely re-written. Conclusions unchange

Curvature invariants in type N spacetimes

Scalar curvature invariants are studied in type N solutions of vacuum Einstein's equations with in general non-vanishing cosmological constant Lambda. Zero-order invariants which include only the metric and Weyl (Riemann) tensor either vanish, or are constants depending on Lambda. Even all higher-order invariants containing covariant derivatives of the Weyl (Riemann) tensor are shown to be trivial if a type N spacetime admits a non-expanding and non-twisting null geodesic congruence. However, in the case of expanding type N spacetimes we discover a non-vanishing scalar invariant which is quartic in the second derivatives of the Riemann tensor. We use this invariant to demonstrate that both linearized and the third order type N twisting solutions recently discussed in literature contain singularities at large distances and thus cannot describe radiation fields outside bounded sources.Comment: 17 pages, to appear in Class. Quantum Gra

Deep Generative Model-based Quality Control for Cardiac MRI Segmentation

In recent years, convolutional neural networks have demonstrated promising performance in a variety of medical image segmentation tasks. However, when a trained segmentation model is deployed into the real clinical world, the model may not perform optimally. A major challenge is the potential poor-quality segmentations generated due to degraded image quality or domain shift issues. There is a timely need to develop an automated quality control method that can detect poor segmentations and feedback to clinicians. Here we propose a novel deep generative model-based framework for quality control of cardiac MRI segmentation. It first learns a manifold of good-quality image-segmentation pairs using a generative model. The quality of a given test segmentation is then assessed by evaluating the difference from its projection onto the good-quality manifold. In particular, the projection is refined through iterative search in the latent space. The proposed method achieves high prediction accuracy on two publicly available cardiac MRI datasets. Moreover, it shows better generalisation ability than traditional regression-based methods. Our approach provides a real-time and model-agnostic quality control for cardiac MRI segmentation, which has the potential to be integrated into clinical image analysis workflows

Inheritance, Biochemical Abnormalities, and Clinical Features of Feline Mucolipidosis II: The First Animal Model of Human I-Cell Disease

Mucolipidosis II (ML II), also called I-cell disease, is a unique lysosomal storage disease caused by deficient activity of the enzyme N-acetylglucosamine-1-phosphotransferase, which leads to a failure to internalize enzymes into lysosomes. We report on a colony of domestic shorthair cats with ML II that was established from a half-sibling male of an affected cat. Ten male and 9 female kittens out of 89 kittens in 26 litters born to clinically normal parents were affected; this is consistent with an autosomal recessive mode of inheritance. The activities of three lysosomal enzymes from affected kittens, compared to normal adult control cats, were high in serum (11-73 times normal) but low in cultured fibroblasts (9-56% of normal range) that contained inclusion bodies (I-cells), reflecting the unique enzyme defect in ML II. Serum lysosomal enzyme activities of adult obligate carriers were intermediate between normal and affected values. Clinical features in affected kittens were observed from birth and included failure to thrive, behavioral dullness, facial dysmorphia, and ataxia. Radiographic lesions included metaphyseal flaring, radial bowing, joint laxity, and vertebral fusion. In contrast to human ML II, diffuse retinal degeneration leading to blindness by 4 months of age was seen in affected kittens. All clinical signs were progressive and euthanasia or death invariably occurred within the first few days to 7 months of life, often due to upper respiratory disease or cardiac failure. The clinical and radiographic features, lysosomal enzyme activities, and mode of inheritance are homologous with ML II in humans. Feline ML II is currently the only animal model in which to study the pathogenesis of and therapeutic interventions for this unique storage diseas

The Importance of Audit Firm Characteristics and the Drivers of Auditor Change in UK Listed Companies

This paper explores the importance of audit firm characteristics and the factors motivating auditor change based on questionnaire responses from 210 listed UK companies (a response rate of 70%). Twenty-nine potentially desirable auditor characteristics are identified from the extant literature and their importance elicited. Exploratory factor analysis reduces these variables to eight uncorrelated underlying dimensions: reputation/quality; acceptability to third parties; value for money; ability to provide non-audit services; small audit firm; specialist industry knowledge; non-Big Six large audit firm; and geographical proximity. Insights into the nature of 'the Big Six factor' emerge. Two thirds of companies had recently considered changing auditors; the main reasons cited being audit fee level, dissatisfaction with audit quality and changes in top management. Of those companies that considered change, 73% did not actually do so, the main reasons cited being fee reduction by the incumbent and avoidance of disruption. Thus audit fee levels are both a key precipitator of change and a key factor in retaining the status quo

Distinguishing G_2-manifolds

In this survey, we describe invariants that can be used to distinguish connected components of the moduli space of holonomy G_2 metrics on a closed 7-manifold, or to distinguish G_2-manifolds that are homeomorphic but not diffeomorphic. We also describe the twisted connected sum and extra-twisted connected sum constructions used to realise G_2-manifolds for which the above invariants differ.Comment: 22 pages, 5 figures. To appear in a forthcoming volume of the Fields Institute Communications, entitled "Lectures and Surveys on G2 manifolds and related topics