11 research outputs found
Synthesis of quinoline-pyrazoline based thiazole derivatives endowed with antimicrobial activity
1191-1201A new series of
2-(5-(2-chloroquinolin-3-yl)-3-(aryl)-4,5-dihydro-1<i style="mso-bidi-font-style:
normal">H-pyrazol-1-yl)thiazol-4(5H)ones
4a-l have been prepared and
characterized by IR, NMR and mass spectroscopy. The synthesized compounds have
been screened for antimicrobial activity against microbial strains: Escherichia coli, Pseudomonas<span style="mso-bidi-font-style:
italic"> aeruginosa, Staphylococcus<span style="mso-bidi-font-style:
italic"> aureus, Streptococcus pyogenes<span style="mso-bidi-font-style:
italic">, Candida albicans, <i style="mso-bidi-font-style:
normal">Aspergillus niger and <i style="mso-bidi-font-style:
normal">Aspergillus clavatus. Almost all the tested compounds are
found to possess variable degrees of antimicrobial activity. Collectively,
compounds 4e, <b style="mso-bidi-font-weight:
normal">4g, 4h, 4i and <b style="mso-bidi-font-weight:
normal">4l can be considered as possible agents with antimicrobial
activity.
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Considerations for large building water quality after extended stagnation
The unprecedented number of building closures related to the coronavirus disease (COVID-19) pandemic is concerning because water stagnation will occur in many buildings that do not have water management plans in place. Stagnant water can have chemical and microbiological contaminants that pose potential health risks for occupants. Health officials, building owners, utilities, and other entities are rapidly developing guidance to address this issue, but the scope, applicability, and details included in the guidance vary widely. To provide a primer of large building water system preventative and remedial strategies, peer-reviewed, government, industry, and nonprofit literature relevant to water stagnation and decontamination practices for plumbing was synthesized. Preventative practices to help avoid the need for recommissioning (e.g., routine flushing) and specific actions, challenges, and limitations associated with recommissioning were identified and characterized. Considerations for worker and occupant safety were also indicated. The intended audience of this work includes organizations developing guidance