Ps at the interfaces : on the syntax, semantics, and morphology of spatial prepositions in German

This dissertation spells out the syntax, semantics, and morphology of spatial prepositions in German. I do this by using a parsimonious model of grammar with only one combinatorial engine that generates both phrases and words: syntax (Marantz 1997, Bruening 2016). I follow the tenets of the Minimalist Program (Chomsky 1995) with Bare Phrase Structure as its phrase structural module. I show that using Distributed Morphology (Halle and Marantz 1993, Embick 2015) to model Phonological Form and Discourse Representation Theory (Kamp and Reyle 1993, Kamp et al. 2011) to model Logical Form makes it possible to gain deeper and new insights into the system of German spatial prepositions. Spatial prepositions are classified along a widely accepted typology (Jackendoff 1983, Piñón 1993, Zwarts 2005, a.o.): (i) place prepositions denote static locations and (ii) path prepositions denote dynamic locations that can be directed, as in the case of goal and source prepositions, or undirected, as in the case of route prepositions. In addition, I propose a classification of spatial prepositions that is orthogonal to the above typology: (i) geometric prepositions express geometric locative relations, which I spell out in a parsimonious, perception-driven model of space (Kamp and Roßdeutscher 2005); (ii) pseudo-geometric prepositions look like geometric prepositions but express functional locative relations instead of geometric ones; and (iii) non-geometric prepositions express a special type of functional locative relations. The fine-grained syntacticosemantic analysis presented in this thesis not only makes it possible to spell out Phonological Form and Logical Form for spatial prepositions, but it also serves as input to a morphological case approach (Marantz 1991, McFadden 2004) that accounts for the case assignment of spatial prepositions

Microangiopathy of cutaneous blood and lymphatic capillaries in chronic venous insufficiency (CVI).

The severity of microangiopathy in patients with chronic venous insufficiency (CVI) determines the extent of the trophic disturbances of the skin. Resulting from valvular incompetence of deep and/or perforating veins and the accompanying venous outflow obstruction caused by deep venous thrombosis (DVT), the increased ambulatory venous pressure heads are transmitted retrograde into the microvasculature of the skin at the ankle region. In the present study, we have assessed the changes in the cutaneous microvasculature by dynamic fluorescence video microscopy, fluorescence microlymphography, and transcutaneous oxygen tension (tcPO2) measurements. In mild forms of CVI, capillary density, morphologic characteristics, and tcPO2 are still normal. Fluorescent light intensity is, however, significantly increased, indicating an increased transcapillary diffusion of sodium fluorescein (NaF) as a marker for enhanced leakage of the capillaries in the early stage of the disease. The pericapillary halo diameters are significantly enlarged, compared to controls (p < 0.01). In the severe stages of CVI and in patients with venous ulcers, capillary thromboses, probably caused by endothelium-blood cell interactions, may lead to a reduced capillary density. In order to enlarge the exchange surface area, the remaining skin capillaries become tortuous (capillary tufts). Parallel to the reduced capillary number, tcPO2 decreases and can be extremely low at the ulcer rim or at white atrophy spots. Fibrin cuffs are not a specific finding for venous ulceration and do not significantly impair oxygen diffusion. Fluorescence microlymphography permits visualization of the lymphatic capillaries of the superficial skin. In severe stages of CVI, the lymphatic capillary network at the medial ankle area is destroyed, and the remaining lymphatic capillary fragments have an increased permeability to FITC-dextran with a molecular weight of 150,000. These findings demonstrate a special lymphatic microangiopathy in CVI, suggesting an additional lymphatic component in the edema formation

Математическая модель потоков покупателей двухпродуктовой торговой компании в виде системы массового обслуживания с повторными обращениями к блокам

Построена математическая модель формирования потока покупателей торговой компании в виде системы параллельного обслуживания кратных заявок с повторным обращением и неограниченным числом обслуживающих приборов, получено выражение для математического ожидания капитала торговой компании, а также найдено условие для существования максимума этой функции. Для конкретного примера определено оптимальное отношение стоимости подарка к средней стоимости покупки, обеспечивающее максимальную прибыль компании

Heat transfer in separated flows on the pressure side of turbine blades

Heat transfer in separated flows on the pressure side of a typical high lift turbine profile is numerically investigated by means of an in-house CFD code. The numerical code was first validated on attached flows in turbine blades. To obtain flow separation cases, the profile is subject to large negative incidences so that a separation bubble is obtained at the pressure side. The numerical results are compared to available experimental data for code validation. It is shown how local minima and maxima values of the heat transfer coefficient are related to the separation and reattachment points, where the velocity component perpendicular to the wall is shown to have a significant effect on the heat transfe

A Novel Porcine In Vitro Model of the Blood-Cerebrospinal Fluid Barrier with Strong Barrier Function

Epithelial cells of the plexus choroideus form the structural basis of the blood-cerebrospinal fluid barrier (BCSFB). In vitro models of the BCSFB presenting characteristics of a functional barrier are of significant scientific interest as tools for examination of BCSFB function. Due to a lack of suitable cell lines as in vitro models, primary porcine plexus epithelial cells were subjected to a series of selective cultivation steps until a stable continuous subcultivatable epithelial cell line (PCP-R) was established. PCP-R cells grow in a regular polygonal pattern with a doubling time of 28–36 h. At a cell number of 1.5×105 in a 24-well plate confluence is reached in 56–72 h. Cells are cytokeratin positive and chromosomal analysis revealed 56 chromosomes at peak (84th subculture). Employing reverse transcription PCR mRNA expression of several transporters and components of cell junctions could be detected. The latter includes tight junction components like Claudin-1 and -3, ZO-1, and Occludin, and the adherens junction protein E-cadherin. Cellular localization studies of ZO-1, Occludin and Claudin-1 by immunofluorescence and morphological analysis by electron microscopy demonstrated formation of a dense tight junction structure. Importantly, when grown on cell culture inserts PCP-R developed typical characteristics of a functional BCSFB including high transepithelial electrical resistance above 600 Ω×cm2 as well as low permeability for macromolecules. In summary, our data suggest the PCP-R cell line as a suitable in vitro model of the porcine BCSFB

European economic constitution and the transformation of democracy : on class and the state of law

In the context of contemporary analyses of the Europe Union as a post-democratic form of economic governance, this article explores the (ordo)liberal character of monetary union as a regime of imposed liberty. The argument holds that rather than forcing the member states into retreat, the economic constitution of Europe strengthens their liberal foundation, securing their utility as the organised force of a mode of social reproduction founded on free labour. It develops the character of the liberal state as the political form of a free market economy with reference to Adam Smith’s classical political economy and the German ordoliberal tradition, which calls for a rule-based system of federated forms of economic governance to secure a free labour economy in conditions of mass democratic aspirations for a freedom from want. It explores the rationale of the ordoliberal distinction between the liberal character and the democratic character of the state and, in this context, assesses the meaning of liberal democracy in a post-democratic Eurozone