To determine the relative factors on hypertension in Kohrang, Chaharmahal & Bakhtiari province, 2007

Background & Objectives: Hypertension is one of the most prevalent and important risk factor of cardio-vascular diseases. The aim of this research was to determine relative factors on hypertension in Kohrang. Methods: This survey was a population–based case-control study. The study population consisted of 415 patient with hypertension (cases) and 415 controls without any history of cardiovascular and or cerebrovascular diseases & hypertension. A systematic random sampling was used. The chi-square test and conditional logistic regression model was used and the data were analyzed by STATA. Results: Family history of hypertension, age over 60, no physical activity, bmi≥ 30 were calculated as risk factors with odds ratio: 2.33 (95% CI 1.58-3.47), 2.01 (95% CI 1.24-2.67), 1.8 (95% CI 1.2- 2.7), 1.66 (95% CI 1.32-2.07) respectively (p< 0.05). Fish consumption, unsaturated fat

Metabolic control and care assessment in patients with type 2 diabetes in Chaharmahal & bakhtiyari province 2008

Introduction: Diabetes mellitus (DM) is a major cause of morbidity and mortality affecting millions of people worldwide, making metabolic control & care assessment in these diabetics very important. The aim of this study was to identify and determine metabolic control rate and care assessment among type 2 diabetics in Chaharmahal & Bakhtiyari Province. Materials and Methods: In this 2008 Analytic- Descriptive (Cross-sectional) study, 256 patients with diabetes type 2 were selected by a two stage random sampling; data were analysed by Software SPSS 13. Results: Mean age of patients was 54.8±11:8.6 years and their mean duration of disease was 7.4 ± 5.8 years. Extent of achievement of aims in control ani care of metabolic care and assessment among patients was 1.2 73.6, 37, 39.4, 79.9, 61.4, 35.4, 62.6 and 37.7 in Hba1 c, cholesterol, triglycerides, systolic blood pressure, diastolic blood pressure, HDL in men, HDL in women, LDL and BMI, respectively. Conclusion: Hypertension, HbA1c, BMI and triglyceride levels were inappropriately controlled, requiring intervention planning and implemention for control of these factors in this province

EFFECTIVE FACTORS IN THE QUALITY OF LIFE IN PATIENTS WITH TYPE 2 DIABETES IN CHAHARMAHAL & BAKHTEYARI PROVINCE

Abstract: Background and objectives: Quality of life can be considered as a marker of the quality of health care and is a part of the patient's treatment plan. Its measurement in type 2 diabetic patients provides useful information to health authorities Material and Methods: This study is a descriptive-analytic cross–sectional study that has attempted to measure the quality of life in diabetic patients in Chaharmahal & Bakhteyari Province. The number of patients was 254 and they were selected randomly in two stages. Data were collected

The survey of family history of diabetes in patients with type 2 diabetes in Chaharmahal va Bakhteyari province, Iran, 2008

چکیده: زمینه و هدف: دیابت از گروه بیماری های متابولیک و یک اختلال چند عاملی است که با افزایش مزمن قند خون مشخص می شود. از آنجایی که در زمینه اپیدمیولوژی ژنتیک دیابت نوع 2 در کشور ما، مطالعات اندکی انجام شده و هنوز بطور قطعی مشخص نیست که توارث دیابت نوع 2 بیشتر از طرف کدام یک از والدین (پدر یا مادر) به فرزندان منتقل می شود، این مطالعه با هدف بررسی زمینه ژنتیکی بیماران دیابتی نوع 2 استان چهارمحال و بختیاری طراحی و اجرا گردید. روش بررسی: این بررسی یک مطالعه اپیدمیولوژیک از نوع توصیفی-تحلیلی است که جامعه پژوهش آن افراد مبتلا به دیابت نوع 2 در استان چهارمحال و بختیاری در سال 1387 بود. تعداد 254 نفر به روش تصادفی دو مرحله ای انتخاب و مورد بررسی قرار گرفتند. داده ها بوسیله مصاحبه و با تکمیل فرمی، جمع آوری و با نرم افزار STATA9 و آزمون مجذور کا مورد تجزیه و تحلیل قرار گرفت. یافته ها: از254 نفر بررسی شده 150 نفر (59) مونث و 104 نفر(41) مذکر بودند. متوسط سن آنها 6/8±8/54 سال و متوسط مدت زمان ابتلا به دیابت در آنها 8/5±4/7 سال بود. 116 نفر (7/45) از آنها دارای سابقه خانوادگی مثبت دیابت بودند که از این میان، 4/61 مادر دیابتی، 8/19 پدر دیابتی، 9/62 خواهر دیابتی، 1/18 برادر دیابتی، 5/40 دختر دیابتی و 1/18 پسر دیابتی داشتند. سابقه خانوادگی دیابت در مادر بیشتر از پدر، در خواهر بیشتر از برادر و در دختران بیشتر از پسران بود (001/0>P). نتیجه گیری: نسبت شانس ابتلا به دیابت برای کسانی که سابقه خانوادگی مثبت دیابت در مادر دارند بیشتر و مهم تر از پدر بوده و می توان اظهار نمود که به احتمال قوی، توارث دیابت نوع 2 بیشتر از طریق مادر به فرزندان منتقل می شود.

Flood loss modelling with FLF-IT: a new flood loss function for Italian residential structures

The damage triggered by different flood events costs the Italian economy millions of euros each year. This cost is likely to increase in the future due to climate variability and economic development. In order to avoid or reduce such significant financial losses, risk management requires tools which can provide a reliable estimate of potential flood impacts across the country. Flood loss functions are an internationally accepted method for estimating physical flood damage in urban areas. In this study, we derived a new flood loss function for Italian residential structures (FLF-IT), on the basis of empirical damage data collected from a recent flood event in the region of Emilia-Romagna. The function was developed based on a new Australian approach (FLFA), which represents the confidence limits that exist around the parameterized functional depth–damage relationship. After model calibration, the performance of the model was validated for the prediction of loss ratios and absolute damage values. It was also contrasted with an uncalibrated relative model with frequent usage in Europe. In this regard, a three-fold cross-validation procedure was carried out over the empirical sample to measure the range of uncertainty from the actual damage data. The predictive capability has also been studied for some sub-classes of water depth. The validation procedure shows that the newly derived function performs well (no bias and only 10 % mean absolute error), especially when the water depth is high. Results of these validation tests illustrate the importance of model calibration. The advantages of the FLF-IT model over other Italian models include calibration with empirical data, consideration of the epistemic uncertainty of data, and the ability to change parameters based on building practices across Italy

Novel loss-of-function variants in CDC14A are associated with recessive sensorineural hearing loss in Iranian and Pakistani patients

CDC14A encodes the Cell Division Cycle 14A protein and has been associated with autosomal recessive non-syndromic hearing loss (DFNB32), as well as hearing impairment and infertile male syndrome (HIIMS) since 2016. To date, only nine variants have been associated in patients whose initial symptoms included moderate-to-profound hearing impairment. Exome analysis of Iranian and Pakistani probands who both showed bilateral, sensorineural hearing loss revealed a novel splice site variant (c.1421+2T>C, p.?) that disrupts the splice donor site and a novel frameshift variant (c.1041dup, p.Ser348Glnfs*2) in the gene CDC14A, respectively. To evaluate the pathogenicity of both loss-of-function variants, we analyzed the effects of both variants on the RNA-level. The splice variant was characterized using a minigene assay. Altered expression levels due to the c.1041dup variant were assessed using RT-qPCR. In summary, cDNA analysis confirmed that the c.1421+2T>C variant activates a cryptic splice site, resulting in a truncated transcript (c.1414_1421del, p.Val472Leufs*20) and the c.1041dup variant results in a defective transcript that is likely degraded by nonsense-mediated mRNA decay. The present study functionally characterizes two variants and provides further confirmatory evidence that CDC14A is associated with a rare form of hereditary hearing loss

Load integration, including radar and advanced weapons

This paper summarizes work that addressed issues associated with the integration of various loads on an all-electric navy ship by the Electric Ship Research and Development Consortium (ESRDC) in the last ten years. The loads include ship service loads such as hotel loads, continuous high-power loads such as propulsion, vital high-power loads such as radar, multi-megawatt pulsed loads such as sensors and defensive systems, and very-high power, gigawatt-level, pulsed loads such as electromagnetic rail guns which require energy storage. The integration of energy storage received particular attention due to its vital role and is discussed accordingly. The analyses were conducted through modeling and simulation and complemented by design studies at component and system levels. Typical simulation results representing operational scenarios of various loads and their interaction with the power system are presented.Center for Electromechanic

The first view of δ Scuti and γ Doradus stars with the TESS mission

We present the first asteroseismic results for δ Scuti and γ Doradus stars observed in Sectors 1 and 2 of the TESS mission. We utilize the 2-min cadence TESS data for a sample of 117 stars to classify their behaviour regarding variability and place them in the Hertzsprung-Russell diagram using Gaia DR2 data. Included within our sample are the eponymous members of two pulsator classes, γ Doradus and SX Phoenicis. Our sample of pulsating intermediate-mass stars observed by TESS also allows us to confront theoretical models of pulsation driving in the classical instability strip for the first time and show that mixing processes in the outer envelope play an important role. We derive an empirical estimate of 74 per cent for the relative amplitude suppression factor as a result of the redder TESS passband compared to the Kepler mission using a pulsating eclipsing binary system. Furthermore, our sample contains many high-frequency pulsators, allowing us to probe the frequency variability of hot young δ Scuti stars, which were lacking in the Kepler mission data set, and identify promising targets for future asteroseismic modelling. The TESS data also allow us to refine the stellar parameters of SX Phoenicis, which is believed to be a blue straggler.Fil: Antoci, Victoria. Stellar Astrophysics Centre; DinamarcaFil: Cunha, M. S.. Universidad de Porto; PortugalFil: Bowman, D. M.. Institute of Astronomy; BélgicaFil: Murphy, S. J.. Stellar Astrophysics Centre; Dinamarca. University of Sydney; AustraliaFil: Kurtz, D. W.. University of Central Lancashire; Reino UnidoFil: Bedding, T. R.. Stellar Astrophysics Centre; Dinamarca. University of Sydney; AustraliaFil: Borre, C. C.. Stellar Astrophysics Centre; DinamarcaFil: Christophe, S.. Universite de Paris I Pantheon - Sorbonne; Francia. Centre National de la Recherche Scientifique. Observatoire de Paris; FranciaFil: Daszynska Daszkiewicz, J.. Instytut Astronomiczny; PoloniaFil: Fox Machado, L.. Universidad Nacional Autónoma de México; MéxicoFil: García Hernández, A.. Universidad de Granada; EspañaFil: Ghasemi, Hamed. Institute For Advanced Studies In Basic Sciences; IránFil: Handberg, R.. Stellar Astrophysics Centre; DinamarcaFil: Hansen, Ted H.. Stellar Astrophysics Centre; DinamarcaFil: Hasanzadeh, A.. University Of Zanjan; IránFil: Houdek, G.. Stellar Astrophysics Centre; DinamarcaFil: Johnston, C.. Katholikie Universiteit Leuven; BélgicaFil: Justesen, A. B.. Stellar Astrophysics Centre; DinamarcaFil: Kahraman Alicavus, F.. Nicolaus Copernicus Astronomical Center Of The Polish Academy Of Sciences; PoloniaFil: Kotysz, K.. Instytut Astronomiczny, Uniwersytet Wrocławski; PoloniaFil: Latham, D.. Harvard-Smithsonian Center for Astrophysics; Estados UnidosFil: Matthews, J. M.. University of British Columbia; CanadáFil: Mønster, J.. Stellar Astrophysics Centre; DinamarcaFil: Niemczura, E.. Uniwersytet Wrocławski; PoloniaFil: Paunzen, E.. Masaryk University; República ChecaFil: Sánchez Arias, Julieta Paz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Pigulski, A.. Uniwersytet Wrocławski; PoloniaFil: Pepper, J.. Lehigh University; Estados UnidosFil: Richey Yowell, T.. Lehigh University; Estados UnidosFil: Safari, H.. University of Zanjan; Irá

Global, regional, and national burden of chronic kidney disease, 1990–2017 : a systematic analysis for the Global Burden of Disease Study 2017

Background Health system planning requires careful assessment of chronic kidney disease (CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-existent in many countries. We estimated the global, regional, and national burden of CKD, as well as the burden of cardiovascular disease and gout attributable to impaired kidney function, for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. We use the term CKD to refer to the morbidity and mortality that can be directly attributed to all stages of CKD, and we use the term impaired kidney function to refer to the additional risk of CKD from cardiovascular disease and gout. Methods The main data sources we used were published literature, vital registration systems, end-stage kidney disease registries, and household surveys. Estimates of CKD burden were produced using a Cause of Death Ensemble model and a Bayesian meta-regression analytical tool, and included incidence, prevalence, years lived with disability, mortality, years of life lost, and disability-adjusted life-years (DALYs). A comparative risk assessment approach was used to estimate the proportion of cardiovascular diseases and gout burden attributable to impaired kidney function. Findings Globally, in 2017, 1·2 million (95% uncertainty interval [UI] 1·2 to 1·3) people died from CKD. The global all-age mortality rate from CKD increased 41·5% (95% UI 35·2 to 46·5) between 1990 and 2017, although there was no significant change in the age-standardised mortality rate (2·8%, −1·5 to 6·3). In 2017, 697·5 million (95% UI 649·2 to 752·0) cases of all-stage CKD were recorded, for a global prevalence of 9·1% (8·5 to 9·8). The global all-age prevalence of CKD increased 29·3% (95% UI 26·4 to 32·6) since 1990, whereas the age-standardised prevalence remained stable (1·2%, −1·1 to 3·5). CKD resulted in 35·8 million (95% UI 33·7 to 38·0) DALYs in 2017, with diabetic nephropathy accounting for almost a third of DALYs. Most of the burden of CKD was concentrated in the three lowest quintiles of Socio-demographic Index (SDI). In several regions, particularly Oceania, sub-Saharan Africa, and Latin America, the burden of CKD was much higher than expected for the level of development, whereas the disease burden in western, eastern, and central sub-Saharan Africa, east Asia, south Asia, central and eastern Europe, Australasia, and western Europe was lower than expected. 1·4 million (95% UI 1·2 to 1·6) cardiovascular disease-related deaths and 25·3 million (22·2 to 28·9) cardiovascular disease DALYs were attributable to impaired kidney function. Interpretation Kidney disease has a major effect on global health, both as a direct cause of global morbidity and mortality and as an important risk factor for cardiovascular disease. CKD is largely preventable and treatable and deserves greater attention in global health policy decision making, particularly in locations with low and middle SDI