Analisis Pengaruh Independensi, Kompetensi dan Predikasi terhadap Keputusan Auditor dalam Menerima Penugasan Audit Investigatif (Studi pada Perwakilan BPKP Provinsi Sumatera Barat)

The purpose of this research is to analyze the influence of independency, competency and predication on the auditor decision in receiving investigative audit assignment, either simultaneously or partially, at the Perwakilan BPKP of Sumatera Barat Province. The research conducted in the scope of the Perwakilan BPKP of Sumatera Barat Province, with the object of research is limited only to the variables of independency, competency and predication as an independent variable and auditor decision in receiving investigative audit assignment as the dependent variable. The population in this research are all auditor who work at the Perwakilan BPKP of Sumatera Barat Province. Samples were taken as much as 42 of the total 71 Auditor or 59,15 percent. Primary data collection method used questionnaire method. The data analysis technique used in this research is the technique of multiple regression analysis by SPSS 23. The results of the research have shown that the independent variable significant simultaneously influence the dependent variable but not partially. Value of the coefficient of determination indicates that together the independency, competency and predication contribute to dependen variabel (auditor decision in receiving Investigative Audit Assignment) of 19,9 percent while the remaining 80,1 percent are influenced by other variables outside factor model. The results recommend the Perwakilan BPKP of Sumatera Barat Province to keep independency, competency and predication as minimal criteria in receving investigative audit assignment. Keywords: independency, competency, predication, auditor decision and investigatif audit

Relationship between Carotid Intima-Media Thickness and Left Ventricular Hypertrophy

Background: Hypertension is a 50% cause of cardiovascular disease and stroke, 40% of cause of death in Diabetics, and is a major risk of kidney failure, pregnancy and dementia. Left ventricular hypertrophy (LVH) is a preclinical manifestation of cardiovascular disease and a strong predictor of cardiovascular morbidity and mortality. Examination of carotid intima-media thickness (CIMT) is one method that can be used to Evaluate the occurrence of coronary heart disease and in Several studies reported that CIMT is also associated with left ventricular function and hypertrophyMethods: This cross-sectional study conducted on hypertensive patients in the outpatient unit in Cardiac Center Haji Adam Malik General Hospital since March 2018-August 2018. Examination of Carotid B-Mode ultrasound was conducted to obtain CIMT values. LVH is assessed by left ventricle mass index (LVMI) as measured by M-mode method using the Cube formulas from echocardiography. Then the analysis is done using the Spearman correlation test to see the relationship between CIMT and LVHResults: The CIMT >0.5 mm have a positive correlation with LVM (r = 0.594, p 0.5 mm has a sensitivity of 83.6%, specificity 90.4%, PPV NPV 76% and 93.8%. The CIMT value of 0:55 mm is considered to be the optimal value in diagnosing LVH in hypertensive patients in our subjects based on the ROC curve with a sensitivity of 83.6% and specificity of 90.5%, and area under the curve of 0.9.Conclusion: There is a positive correlation between carotid intima-media thickness and left ventricular hypertrophy in hypertensive patient

In Vivo Metabolism of Topically Applied Benzo[a]pyrene-4,5-oxide in Neonatal Rat Skin

The metabolism of benzo[a]pyrene (BP)-4,5-oxide in the skin and liver of neonatal rats was studied after topical application of the arene oxide in vivo. The metabolism of BP-4,5-oxide was time-dependent and showed a 2-h maximum for BP-4,5-dihydrodiol formation in both skin and liver. Product formation was also dose-dependent. Inhibitors of epoxide hydrolase such as clotrimazole, 1,1,1,-trichloropropene oxide, and cyclohexene oxide largely abolished the formation of BP-4,5-dihydrodiol. The rapid biotransformation of arene oxides such as BP-4,5-oxide in the skin emphasizes the potential importance of epoxide hydrolase in the activation and inactivation of polycyclic aromatic hydrocarbons. Furthermore, the topically applied arene oxide also penetrated the skin and was rapidly metabolized in the liver as well

The Effect of Salam Leaf (Syzygium polyanthum [Wight] Walp.) Extract on Inflammation in Rat Model of Acute Coronary Syndrome

AIM: The aim of the study was to determine the effect of Salam leaf extract on regenerating islet-derived protein 3 β (Reg3β) and C-reactive protein (CRP) in cardiomyocyte of rat model of ACS. METHODS: Thirty-six male Wistar rats were divided into three groups: Negative control group, positive control group (ACS-induced group), and treatment group (ACS-induced group with Salam leaf administration). Macroscopic appearance and histopathology examination were done to ensure the occurrence of infarction. Reg3β and CRP levels were measured and compared between the positive control group and treatment group. RESULTS: There were significantly lower Reg3β and CRP levels in the treatment group than in the positive control group from day 4 to day 14. CONCLUSION: These data suggest that a Salam leaf extract can improve inflammation by decreasing Reg3β and CRP levels in rat model of ACS

Resveratrol-loaded nanoparticles based on polymeric blend for prostsate cancer treatment

The trans-resveratrol (RSV) has been reported to act as an antiproliferative and chemopreventive agent against a wide variety of tumors, including prostate cancer (PCa)I,2. Nanoencapsulation of RSV represents a powerful strategy to provide protection of degradation, enhancement of bioavailability, improvement of intracellular penetration and control delivery,4. We developed novel polymeric nanoparticles (NPs) encapsulating RSV (nano-RSV), based on a polymeric blend, as effective prototypes for PCa treatment. Our results support the potential use of these prototypes for the controlled delivery ofRSV for PCa treatment

The Effect of Psoralens on Hepatic and Cutaneous Drug Metabolizing Enzymes and Cytochrome P-450

Psoralens are tricyclic furocoumarins with potent photosensitizing properties in the skin and are now widely used in the treatment of several dermatologic diseases. In this study the effect of 3 different psoralens 8-methoxypsoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP) and isopsoralen on hepatic microsomal drug-metabolizing enzymes and cytochrome P-450 has been assessed in mice and rats. 8-MOP administered orally to CD-1 mice daily for 6days caused 2–3 fold increases in hepatic aryl hydrocarbon hydroxylase (AHH), ethylmorphine N-demethylase and cytochrome P-450. The absorbance maximum of the induced cytochrome was at 450nm. Aniline hydroxylase activity was unchanged. Chronic administration of 8-MOP, to hairless mice caused significant enhancement of hepatic ethylmorphine N-demethylase and cytochrome P-450 but had no effect on AHH; whereas chronically administered TMP had no significant effect on any of these parameters. Isopsoralen and TMP administered orally to CD-1 mice daily for 6days had no effect on any of these liver enzymes or on hepatic drug-metabolizing enzymes and cytochrome P-450 to a lesser extent than do the barbituaes and suggest that this drug could influence the rate of biotransformation of concomitantly administered drugs in patients undergoing PUVA therapy

ANALISIS USABILITY PADA WEB AKADEMIK PERGURUAN TINGGI KEAGAMAAN ISLAM NEGERI DI PROVINSI ACEH

Fokus penelitian ini terkait dengan usability web akademik pada Perguruan Tinggi Keagamaan Islam (PTKIN) di Provinsi Aceh. Penelitian ini menggunakan dengan menggunakan metode kuantitatif deskriptif, yaitu suatu pendekatan yang menggunakan ukuran nominal untuk mengambarkan dan melukiskan secara sistematis, faktual, dan akurat mengenai fakta–fakta, sifat-sifat serta hubungan fenomena yang diselidiki. Objek Penelitian adalah web akademik pada tiga perguruan tinggi keagamaan Islam Negeri di Provinsi Aceh, yaitu Sistem Informasi Akademik (SIAKAD) UIN Ar-Raniry, IAIN Lhokseumawe dan IAIN Langsa. Sampel penelitian adalah mahasiswa UIN Ar-Raniry, IAIN Langsa, dan IAIN Lhokseumawe tahun masuk 2017 yang berjumlah 789 mahasiswa. Adapun teknik pengumpulan data yang digunakan adalah angket. Sedangkan teknik analisis data yang digunakan untuk menjawab pertanyaan penelitian adalah analisis presentasi relatif, yaitu menafsirkan data dengan cara membuat presentasi dari setiap hasil responden yang diperoleh. Temuan penelitian ini menunjukkan bahwa tingkat usability web akademik pada Perguruan Tinggi Keagamaan Islam Negeri (PTKIN) di Provinsi Aceh, yaitu UIN Ar-Raniry, IAIN Langsa dan IAIN Lhokseumawe adalah tinggi. Hal ini ditandai dari nilai skor rata-rata tingkat learnability, efficiency, memorability, dan satisfaction tergolong dalam rentang 3.76 – 3.85 persen. Namun demikian, tingkat errors yang dialami oleh mahasiswa pada saat menggunakan web akademik juga tinggi

Comparison of TIMI Flow in STEMI Patients With and Without Resolution on Reciprocal ST Segment Depression Obtaining Fibrinolytic Alteplase Therapy

Background: STEMI patients need revascularization to improve blood flow and myocardial reperfusion. Further information can be obtained from the ECG including infarct size and prognosis of STEMI patients. ST segment depression (STSD) in reciprocal leads isassociated with poorer prognosis. STEMI patients with STSD resolution have a better TIMI flow compared with no STSD resolution. The aim of this study was to look for TIMI flow for STEMI subjects who received fibrinolytic therapy with and without resolution of STSD shortly after fibrinolytic.Methods: This study is a prospective cohort study, in which 60 STEMI subjects, patients performed coronary angiography diagnostics to assess TIMI flow. The resolution on reciprocal STSD is defined as a decrease of 50% in the amount of reciprocal STSD in 90- minute after fibrinolytic therapy started.Results: Bivariate analysis showed that ejection fraction <40% with p = <0.001; QRS duration, p = <0.001; anterior STEMI with p = <0.001; are significant factors for STSD resolution. QRS Fragmentation with p = <0.001; STSD resolution with p = <0.001; ST elevation resolution with p = <0.001; are significant factors for TIMI Flow. In the TIMI Flow comparison with reciprocal STSD resolution; the resolution of reciprocal STSD has a better TIMI flow with OR 28 [(5.5-141.9), p = <0.001].Conclusion: There were differences in TIMI Flow in STEMI patients with reciprocal STSD resolution and without reciprocal STSD resolution who received fibrinolytic alteplase therapy, where STEMI patients with reciprocal STSD resolution had a better TIMI Flow compared with STEMI patients without reciprocal STSD resolution

Upregulation of PI3K/AKT/mTOR, FABP5 and PPARβ/δ in human psoriasis and imiquimodinduced murine psoriasiform dermatitis model

Artículo científicoPsoriasis is a common, and currently incurable chronic immune-mediated skin disease, with incompletely understood etiology partially due to the unavailability of animal models that can emulate major features of the disease