Quantum Black Holes

Static solutions of large-$N$ quantum dilaton gravity in $1+1$ dimensions are analyzed and found to exhibit some unusual behavior. As expected from previous work, infinite-mass solutions are found describing a black hole in equilibrium with a bath of Hawking radiation. Surprisingly, the finite mass solutions are found to approach zero coupling both at the horizon and spatial infinity, with a ``bounce'' off of strong coupling in between. Several new zero mass solutions -- candidate quantum vacua -- are also described.Comment: 14 pages + 6 figure

Imaging Microwave Electric Fields Using a Near-Field Scanning Microwave Microscope

By scanning a fine open-ended coaxial probe above an operating microwave device, we image local electric fields generated by the device at microwave frequencies. The probe is sensitive to the electric flux normal to the face of its center conductor, allowing different components of the field to be imaged by orienting the probe appropriately. Using a simple model of the microscope, we are able to interpret the system's output and determine the magnitude of the electric field at the probe tip. We show images of electric field components above a copper microstrip transmission line driven at 8 GHz, with a spatial resolution of approximately 200 $\mu$m.Comment: 10 pages, 3 eps-figures, accepted by Appl. Phys. Let

Challenges and Opportunities to Updating Prescribing Information for Longstanding Oncology Drugs.

A number of important drugs used to treat cancer-many of which serve as the backbone of modern chemotherapy regimens-have outdated prescribing information in their drug labeling. The Food and Drug Administration is undertaking a pilot project to develop a process and criteria for updating prescribing information for longstanding oncology drugs, based on the breadth of knowledge the cancer community has accumulated with the use of these drugs over time. This article highlights a number of considerations for labeling updates, including selecting priorities for updating; data sources and evidentiary criteria; as well as the risks, challenges, and opportunities for iterative review to ensure prescribing information for oncology drugs remains relevant to current clinical practice

Evanescent Black Holes

A renormalizable theory of quantum gravity coupled to a dilaton and conformal matter in two space-time dimensions is analyzed. The theory is shown to be exactly solvable classically. Included among the exact classical solutions are configurations describing the formation of a black hole by collapsing matter. The problem of Hawking radiation and backreaction of the metric is analyzed to leading order in a $1/N$ expansion, where $N$ is the number of matter fields. The results suggest that the collapsing matter radiates away all of its energy before an event horizon has a chance to form, and black holes thereby disappear from the quantum mechanical spectrum. It is argued that the matter asymptotically approaches a zero-energy ``bound state'' which can carry global quantum numbers and that a unitary $S$-matrix including such states should exist.Comment: 14 page

Across the Indian Ocean: a remarkable example of trans-oceanic dispersal in an austral mygalomorph spider [dataset]

The Migidae are a family of austral trapdoor spiders known to show a highly restricted and disjunct distribution pattern. Here, we aim to investigate the phylogeny and historical biogeography of the group, which was previously thought to be vicariant in origin, and examine the biogeographic origins of the genus Moggridgea using a dated multi-gene phylogeny. Moggridgea specimens were sampled from southern Australia and Africa, and Bertmainus was sampled from Western Australia. Sanger sequencing methods were used to generate a robust six marker molecular dataset consisting of the nuclear genes 18S rRNA, 28S rRNA, ITS rRNA, XPNPEP3 and H3 and the mitochondrial gene COI. Bayesian and Maximum Likelihood methods were used to analyse the dataset, and the key dispersal nodes were dated using BEAST. Based on our data, we demonstrate that Moggridgea rainbowi from Kangaroo Island, Australia is a valid member of the otherwise African genus Moggridgea. Molecular clock dating analyses show that the inter-specific divergence of M. rainbowi from African congeners is between 2.27–16.02 million years ago (Mya). This divergence date significantly post-dates the separation of Africa from Gondwana (95 Mya) and therefore does not support a vicariant origin for Australian Moggridgea. It also pre-dates human colonisation of Kangaroo Island, a result which is further supported by the intra-specific divergence date of 1.10–6.39 Mya between separate populations on Kangaroo Island. These analyses provide strong support for the hypothesis that Moggridgea colonised Australia via long-distance trans-Indian Ocean dispersal, representing the first such documented case in a mygalomorph spider

Entropy in Black Hole Pair Production

Pair production of Reissner-Nordstrom black holes in a magnetic field can be described by a euclidean instanton. It is shown that the instanton amplitude contains an explicit factor of $e^{A/4}$, where $A$ is the area of the event horizon. This is consistent with the hypothesis that $e^{A/4}$ measures the number of black hole states.Comment: 24 pages (harvmac l mode

Four Dimensional Black Holes in String Theory

Exact solutions of heterotic string theory corresponding to four-dimensional charge Q magnetic black holes are constructed as tensor products of an SU(2)/Z(2Q+2) WZW orbifold with a (0,1) supersymmetric SU(1,1)/U(1) WZW coset model. The spectrum is analyzed in some detail. ``Bad'' marginal operators are found which are argued to deform these theories to asymptotically flat black holes. Surprising behaviour is found for small values of Q, where low-energy field theory is inapplicable. At the minimal value Q=1, the theory degenerates. Renormalization group arguments are given that suggest the potential gravitational singularity of the low-energy field theory is resolved by a massive two-dimensional field theory. At Q=0, a stable, neutral ``remnant,'' of potential relevance to the black hole information paradox, is found.Comment: 37 pages + 1 figure (tar compressed and uuencoded

Epidural Electrical Stimulation for Stroke Rehabilitation: Results of the Prospective, Multicenter, Randomized, Single-Blinded Everest Trial.

BackgroundThis prospective, single-blinded, multicenter study assessed the safety and efficacy of electrical epidural motor cortex stimulation (EECS) in improving upper limb motor function of ischemic stroke patients with moderate to moderately severe hemiparesis.MethodsPatients ≥ 4 months poststroke were randomized 2:1 to an investigational (n = 104) or control (n = 60) group, respectively. Investigational patients were implanted (n = 94) with an epidural 6-contact lead perpendicular to the primary motor cortex and a pulse generator. Both groups underwent 6 weeks of rehabilitation, but EECS was delivered to investigational patients during rehabilitation. The primary efficacy endpoint (PE) was defined as attaining a minimum improvement of 4.5 points in the upper extremity Fugl-Meyer (UEFM) scale as well as 0.21 points in the Arm Motor Ability Test (AMAT) 4 weeks postrehabilitation. Follow-up assessments were performed 1, 4, 12, and 24 weeks postrehabilitation. Safety was evaluated by monitoring adverse events (AEs) that occurred between enrollment and the end of rehabilitation.ResultsPrimary intent-to-treat analysis showed no group differences at 4 weeks, with PE being met by 32% and 29% of investigational and control patients, respectively (P = .36). Repeated-measures secondary analyses revealed no significant treatment group differences in mean UEFM or AMAT scores. However, post hoc comparisons showed that a greater proportion of investigational (39%) than control (15%) patients maintained or achieved PE (P = .003) at 24 weeks postrehabilitation. Investigational group mean AMAT scores also improved significantly (P < .05) when compared to the control group at 24 weeks postrehabilitation. Post hoc analyses also showed that 69% (n = 9/13) of the investigational patients who elicited movement thresholds during stimulation testing met PE at 4 weeks, and mean UEFM and AMAT scores was also significantly higher (P < .05) in this subgroup at the 4-, 12-, and 24-week assessments when compared to the control group. Headache (19%), pain (13%), swelling (7%), and infection (7%) were the most commonly observed implant procedure-related AEs. Overall, there were 11 serious AEs in 9 investigational group patients (7 procedure related, 4 anesthesia related).ConclusionsThe primary analysis pertaining to efficacy of EECS during upper limb motor rehabilitation in chronic stroke patients was negative at 4 weeks postrehabilitation. A better treatment response was observed in a subset of patients eliciting stimulation induced upper limb movements during motor threshold assessments performed prior to each rehabilitation session. Post hoc comparisons indicated treatment effect differences at 24 weeks, with the control group showing significant decline in the combined primary outcome measure relative to the investigational group. These results have the potential to inform future chronic stroke rehabilitation trial design

Effects of nitroethane and 2-nitropropanol against Campylobacter jejuni

Campylobacter jejuni is an important foodborne pathogen that colonizes the gut of swine. In this study, the effects of nitroethane and 2-nitropropanol (0, 10 and 20 mM) on growth of C. jejuni were tested during culture in Bolton broth adjusted to pH of 5.6, 7.0 or 8.2. Viable cell counts of samples taken at intervals during incubation revealed main effects (P\u3c0.0001) of nitroethane or 2-nitropropanol on mean specific growth rates thus demonstrating that these were inhibitory to C. jejuni. By 48 h of incubation, C. jejuni concentrations had increased by 1.9 log10 CFU/ml or higher in cultures containing no added nitrocompound