Decision support for crew rostering at NS

This paper describes a method for solving the cyclic crew rostering problem (CCRP). This is the problem of cyclically ordering a set of duties for a number of crew members, such that several complex constraints are satisfied and such that the quality of the obtained roster is as high as possible. The described method was tested on a number of instances of NS, the largest operator of passenger trains in the Netherlands. These instances involve the generation of rosters for groups of train drivers or conductors of NS. The tests show that high quality solutions for practical instances of the CCRP can be generated in an acceptable amount of computing time. Finally, we describe an experiment where we constructed rosters in an automatic way for a group of conductors. They preferred our - generated - rosters over their own manually constructed rosters

Herd immunity to Newcastle disease virus in poultry by vaccination

Newcastle disease is an economically important disease of poultry for which vaccination is applied as a preventive measure in many countries. Nevertheless, outbreaks have been reported in vaccinated populations. This suggests that either the vaccination coverage level is too low or that vaccination does not provide perfect immunity, allowing the virus to spread in partially vaccinated populations. Here we study the requirements of an epidemiologically effective vaccination program against Newcastle disease in poultry, based on data from experimental transmission studies. The transmission studies indicate that vaccinated birds with low or undetectable antibody titres may be protected against disease and mortality but that infection and transmission may still occur. In fact, our quantitative analyses show that Newcastle disease virus is highly transmissible in poultry with low antibody titres. As a consequence, herd immunity can only be achieved if a high proportion of birds (>85%) have a high antibody titre (log2 haemagglutination inhibition titre ≥3) after vaccination. We discuss the implications for the control of Newcastle disease in poultry by vaccination

Decision support for crew rostering at NS

This paper describes a method for solving the cyclic crew rostering problem (CCRP). This is the problem of cyclically ordering a set of duties for a number of crew members, such that several complex constraints are satisfied and such that the quality of the obtained roster is as high as possible. The described method was tested on a number of instances of NS, the largest operator of passenger trains in the Netherlands. These instances involve the generation of rosters for groups of train drivers or conductors of NS. The tests show that high quality solutions for practical instances of the CCRP can be generated in an acceptable amount of computing time. Finally, we describe an experiment where we constructed rosters in an automatic way for a group of conductors. They preferred our—generated—rosters over their own manually constructed rosters

Energy Restriction during Childhood and Early Adulthood and Ovarian Cancer Risk

Dietary energy restriction may protect against cancer. In parts of the Netherlands, mostly in larger cities, periods of chronically impaired nutrition and even severe famine (Hunger Winter 1944–1945) existed during the 1930s and World War II (1940–1945). We studied the association between energy restriction during childhood and early adulthood on the risk of ovarian cancer later in life. In 1986, the Netherlands Cohort Study was initiated. A self-administered questionnaire on dietary habits and other cancer risk factors was completed by 62,573 women aged 55–69 years at baseline. Follow-up for cancer was established by record linkage to the Netherlands Cancer Registry. After 16.3 years of follow-up, 364 invasive epithelial ovarian cancer cases and 2220 subcohort members (sampled from the total cohort directly after baseline) with complete information confounders were available for case-cohort analyses. In multivariable analysis, ovarian cancer risk was lower for participants with an unemployed father during the 1930s (Hazard Ratio (HR), 0.70; 95% Confidence Interval (CI), 0.47–1.06) compared to participants with an employed father as well as for participants living in a city during World War II (HR, 0.69; 95% CI, 0.54–0.90) compared to participants living in the country-side. Residence in a Western City during the famine (Hunger Winter) was not associated with a decreased risk. Our results show a relation between proxy variables for modest energy restriction over a longer period of time during childhood or early adulthood and a reduced ovarian cancer risk

A review of non-linear structural control techniques

In this articles the authors present a review of non-linear structural control techniques. This is an area of growing importance in a range of engineering applications, where non-linear behaviour is encountered. Structural control is usually divided into three main areas: (a) passive (b) semi-active, and (c) active control. This article follows this convention, and highlights in each section the relevant state of the art for non-linear systems, with additional references to related linear approaches

Random-Matrix Theory of Quantum Transport

This is a comprehensive review of the random-matrix approach to the theory of phase-coherent conduction in mesocopic systems. The theory is applied to a variety of physical phenomena in quantum dots and disordered wires, including universal conductance fluctuations, weak localization, Coulomb blockade, sub-Poissonian shot noise, reflectionless tunneling into a superconductor, and giant conductance oscillations in a Josephson junction.Comment: 85 pages including 52 figures, to be published in Rev.Mod.Phy

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo