Geology as a Contribution to Land Use Planning in LaPorte County, Indiana

LaPorte County, in northwestern Indiana, is in a geologically complex region underlain at shallow depths by depositional sequences of glacial till, 1 outwash sand and gravel, and lacustrine silt and clay. The combined agents of ice, wind, and water have sculptured these deposits into a topographically varied landscape ranging from sandy flats of the Kankakee Outwash and Lacustrine Plain to partly wooded hilly uplands on the Valparaiso Moraine. Beneath the glacial materials, which range from 25 to 350 feet in thickness, is a sequence of Paleozoic rocks that is about 4,000 feet thick. Limestone, dolomite, sandstone, and shale, complexly interlayered and varying in thickness, make up the bedrock units, which provide ground water potential and contain potentially commercial deposits of gypsum near LaPorte

Role of the (Mn)superoxide dismutase of Enterococcus faecalis in the in vitro interaction with microglia

Enterococcus faecalis is a significant human pathogen worldwide and is responsible for severenosocomial and community-acquired infections. Although enterococcal meningitis is rare,mortality is considerable, reaching 21 %. Nevertheless, the pathogenetic mechanisms of thisinfection remain poorly understood, even though the ability of E. faecalis to avoid or survivephagocytic attack in vivo may be very important during the infection process. We previouslyshowed that the manganese-cofactored superoxide dismutase (MnSOD) SodA of E. faecalis wasimplicated in oxidative stress responses and, interestingly, in the survival within mouse peritonealmacrophages using an in vivo\u2013in vitro infection model. In the present study, we investigated therole of MnSOD in the interaction of E. faecalis with microglia, the brain-resident macrophages. Byusing an in vitro infection model, murine microglial cells were challenged in parallel with the wildtypestrain JH2-2 and its isogenic sodA deletion mutant. While both strains were phagocytosedby microglia efficiently and to a similar extent, the DsodA mutant was found to be significantlymore susceptible to microglial killing than JH2-2, as assessed by the antimicrobial protectionassay. In addition, a significantly higher percentage of acidic DsodA-containing phagosomes wasfound and these also underwent enhanced maturation as determined by the expression ofendolysosomal markers. In conclusion, these results show that the MnSOD of E. faecaliscontributes to survival of the bacterium in microglial cells by influencing their antimicrobial activity,and this could even be important for intracellular killing in neutrophils and thus for E. faecalispathogenesis

Survival of Enterococcus faecalis in root canals ex vivo

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72532/1/j.1365-2591.2005.01009.x.pd

Parallelization of the discrete gradient method of non-smooth optimization and its applications

We investigate parallelization and performance of the discrete gradient method of nonsmooth optimization. This derivative free method is shown to be an effective optimization tool, able to skip many shallow local minima of nonconvex nondifferentiable objective functions. Although this is a sequential iterative method, we were able to parallelize critical steps of the algorithm, and this lead to a significant improvement in performance on multiprocessor computer clusters. We applied this method to a difficult polyatomic clusters problem in computational chemistry, and found this method to outperform other algorithms. <br /

Unbiased Global Optimization of Lennard-Jones Clusters for N <= 201 by Conformational Space Annealing Method

We apply the conformational space annealing (CSA) method to the Lennard-Jones clusters and find all known lowest energy configurations up to 201 atoms, without using extra information of the problem such as the structures of the known global energy minima. In addition, the robustness of the algorithm with respect to the randomness of initial conditions of the problem is demonstrated by ten successful independent runs up to 183 atoms. Our results indicate that the CSA method is a general and yet efficient global optimization algorithm applicable to many systems.Comment: revtex, 4 pages, 2 figures. Physical Review Letters, in pres

Performance characterization and near-realtime monitoring of MUSE adaptive optics modes at Paranal

The Multi Unit Spectroscopic Explorer (MUSE) is an integral field spectrograph on the Very Large Telescope Unit Telescope 4, capable of laser guide star assisted and tomographic adaptive optics using the GALACSI module. Its observing capabilities include a wide field (1 square arcmin), ground layer AO mode (WFM-AO) and a narrow field (7.5"x7.5"), laser tomography AO mode (NFM-AO). The latter has had several upgrades in the 4 years since commissioning, including an optimisation of the control matrices for the AO system and a new sub-electron noise detector for its infra-red low order wavefront sensor. We set out to quantify the NFM-AO system performance by analysing $\sim$230 spectrophotometric standard star observations taken over the last 3 years. To this end we expand upon previous work, designed to facilitate analysis of the WFM-AO system performance. We briefly describe the framework that will provide a user friendly, semi-automated way for system performance monitoring during science operations. We provide the results of our performance analysis, chiefly through the measured Strehl ratio and full width at half maximum (FWHM) of the core of the point spread function (PSF) using two PSF models, and correlations with atmospheric conditions. These results will feed into a range of applications, including providing a more accurate prediction of the system performance as implemented in the exposure time calculator, and the associated optimization of the scientific output for a given set of limiting atmospheric conditions.Comment: SPIE proceedings (2022), Observatory Operations: Strategies, Processes, and Systems I

Structural Transitions and Global Minima of Sodium Chloride Clusters

In recent experiments on sodium chloride clusters structural transitions between nanocrystals with different cuboidal shapes were detected. Here we determine reaction pathways between the low energy isomers of one of these clusters, (NaCl)35Cl-. The key process in these structural transitions is a highly cooperative rearrangement in which two parts of the nanocrystal slip past one another on a {110} plane in a direction. In this way the nanocrystals can plastically deform, in contrast to the brittle behaviour of bulk sodium chloride crystals at the same temperatures; the nanocrystals have mechanical properties which are a unique feature of their finite size. We also report and compare the global potential energy minima for (NaCl)NCl- using two empirical potentials, and comment on the effect of polarization.Comment: extended version, 13 pages, 8 figures, revte

Uncovering treatment burden as a key concept for stroke care: a systematic review of qualitative research

&lt;b&gt;Background&lt;/b&gt; Patients with chronic disease may experience complicated management plans requiring significant personal investment. This has been termed ‘treatment burden’ and has been associated with unfavourable outcomes. The aim of this systematic review is to examine the qualitative literature on treatment burden in stroke from the patient perspective.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Methods and findings&lt;/b&gt; The search strategy centred on: stroke, treatment burden, patient experience, and qualitative methods. We searched: Scopus, CINAHL, Embase, Medline, and PsycINFO. We tracked references, footnotes, and citations. Restrictions included: English language, date of publication January 2000 until February 2013. Two reviewers independently carried out the following: paper screening, data extraction, and data analysis. Data were analysed using framework synthesis, as informed by Normalization Process Theory. Sixty-nine papers were included. Treatment burden includes: (1) making sense of stroke management and planning care, (2) interacting with others, (3) enacting management strategies, and (4) reflecting on management. Health care is fragmented, with poor communication between patient and health care providers. Patients report inadequate information provision. Inpatient care is unsatisfactory, with a perceived lack of empathy from professionals and a shortage of stimulating activities on the ward. Discharge services are poorly coordinated, and accessing health and social care in the community is difficult. The study has potential limitations because it was restricted to studies published in English only and data from low-income countries were scarce.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Conclusions&lt;/b&gt; Stroke management is extremely demanding for patients, and treatment burden is influenced by micro and macro organisation of health services. Knowledge deficits mean patients are ill equipped to organise their care and develop coping strategies, making adherence less likely. There is a need to transform the approach to care provision so that services are configured to prioritise patient needs rather than those of health care systems