Adaptive digital signal processing Java teaching tool

This publication presents a JAVA program for teaching the rudiments of adaptive digital signal processing (DSP) algorithms and techniques. Adaptive DSP is on of the most important areas of signal processsing, and provides the core algorithmic means to implement applications ranging from mobile telephone speech coding, to noise cancellation, to communication channel equalization. Over the last 30 years adaptive digital signal processing has progressed from being a strictly graduate level advanced class in signal processing theory to a topic that is part of the core curriculum for many undergraduate signal processing classes. The JAVA applet presented in this publication has been devised for students to use in combination with lecture notes and/or one of the recognised textbooks such that they can quickly and conveniently simulate algorithms such as the LMS (least mean squares), RLS (recursive least squares) and so on in a variety of applications without requiring to write programs or scripts or using any special purpose software. By the very nature of the JAVA code therefore, the applet can be run from any browser, even over a low bandwidth modem connection

How Can Primary Teachers Use Digital Resources To Enhance Reading Instruction?

This Capstone project answers the question: how can primary teachers use digital resources to enhance reading instruction? Research has demonstrated that students need exposure to both print and digital literacies. This paper reviews effective reading instruction and highlights the importance of integrating digital technologies in primary classrooms, focusing on kindergarten, first, and second grades. The project involved identifying quality digital resources that support literacy development in elementary grade levels. A website was developed to combine the findings based on research with digital resources that support targeted learning objectives. Specific digital resources are analyzed using both the Common Core State Standards and the SAMR Model (Puentedura, 2014). The goal of the project is to help locate quality digital resources that enhance reading instruction by supporting the development of standards-based learning goals

System Level Design Considerations for HSUPA User Equipment

Publication in the conference proceedings of EUSIPCO, Florence, Italy, 200

Design of Near Perfect Reconstruction Oversampled Filter Banks for Subband Adaptive Filters

In this brief, a design algorithm for real-valued and complex-valued oversampled filter banks which yield a low level of inband alias and enable simple subband adaptiv structures is presented. The filter banks are either based on complex modulation of a real-valued low-pass prototype or on the direct or modulated setups of real-valued filter banks. If real-valued filter banks are required, then the different channels will have different subsampling ratios so that the bandpass sampling theorem is not violated. This brief also presents design examples of real-valued and complex-valued filter banks

Accounting Profession in Argentina; Professional Accounting in Foreign Country Series

https://egrove.olemiss.edu/aicpa_guides/1667/thumbnail.jp

Molecular basis for the sensitivity of TRP channels to polyunsaturated fatty acids

Transient receptor potential (TRP) channels represent a superfamily of unselective cation channels that are subdivided into seven subfamilies based on their sequence homology and differences in gating and functional properties. Little is known about the molecular mechanisms of TRP channel regulation, particularly of the "canonical" TRP (TRPC) subfamily and their activation by polyunsaturated fatty acids (PUFAs). Here, we analyzed the structure-function relationship of Drosophila fruit fly TRPC channels. The primary aim was to uncover the molecular basis of PUFA sensitivity of Drosophila TRP-like (TRPL) and TRPgamma channels. Amino acid (aa) sequence alignment of the three Drosophila TRPC channels revealed 50 aa residues highly conserved in PUFA-sensitive TRPL and TRPgamma channels but not in the PUFA-insensitive TRP channel. Substitution of respective aa in TRPL by corresponding aa of TRP identified 18 residues that are necessary for PUFA-mediated activation of TRPL. Most aa positions are located within a stretch comprising transmembrane domains S2-S4, whereas six aa positions have been assigned to the proximal cytosolic C-terminus. Interestingly, residues I465 and S471 are required for activation by 5,8,11,14-eicosatetraynoic acid (ETYA) but not 5,8,11-eicosatriynoic acid (ETI). As proof of concept, we generated a PUFA-sensitive TRP channel by exchanging the corresponding aa from TRPL to TRP. Our study demonstrates a specific aa pattern in the transmembrane domains S2-S4 and the proximal C-terminus essential for TRP channel activation by PUFAs

A CD2AP mutation associated with focal segmental glomerulosclerosis in young adulthood

Mutations in CD2-associated protein (CD2AP) have been identified in patients with focal segmental glomerulosclerosis (FSGS); however, reports of CD2AP mutations remain scarce. We performed Sanger sequencing in a patient with steroid-resistant FSGS and identified a heterozygous CD2AP mutation (p.T374A, c.1120 A > G). Our patient displayed mild cognitive decline, a phenotypic characteristic not previously associated with CD2AP-associated FSGS. His proteinuria was remarkably reduced by treatment with cyclosporine A. Our findings expand the genetic spectrum of CD2AP-associated disorders and broaden the associated phenotype with the co-occurrence of cognitive decline. Our case shows that cyclosporin A is a treatment option for CD2AP-associated nephropathy

Nanodiscs for INPHARMA NMR Characterization of GPCRs: Ligand Binding to the Human A2A Adenosine Receptor.

G-protein-coupled-receptors (GPCRs) are of fundamental importance for signal transduction through cell membranes. This makes them important drug targets, but structure-based drug design (SBDD) is still hampered by the limitations for structure determination of unmodified GPCRs. We show that the interligand NOEs for pharmacophore mapping (INPHARMA) method can provide valuable information on ligand poses inside the binding site of the unmodified human A2A adenosine receptor reconstituted in nanodiscs. By comparing experimental INPHARMA spectra with back-calculated spectra based on ligand poses obtained from molecular dynamics simulations, a complex structure for A2A R with the low-affinity ligand 3-pyrrolidin-1-ylquinoxalin-2-amine was determined based on the X-ray structure of ligand ZM-241,358 in complex with a modified A2A R

Paraunitary oversampled filter bank design for channel coding

Oversampled filter banks (OSFBs) have been considered for channel coding, since their redundancy can be utilised to permit the detection and correction of channel errors. In this paper, we propose an OSFB-based channel coder for a correlated additive Gaussian noise channel, of which the noise covariance matrix is assumed to be known. Based on a suitable factorisation of this matrix, we develop a design for the decoder's synthesis filter bank in order to minimise the noise power in the decoded signal, subject to admitting perfect reconstruction through paraunitarity of the filter bank. We demonstrate that this approach can lead to a significant reduction of the noise interference by exploiting both the correlation of the channel and the redundancy of the filter banks. Simulation results providing some insight into these mechanisms are provided