Discovery of pulsations, including possible pressure modes, in two new extremely low mass, He-core white dwarfs

We report the discovery of the second and third pulsating extremely low mass white dwarfs (WDs), SDSS J111215.82+111745.0 (hereafter J1112) and SDSS J151826.68+065813.2 (hereafter J1518). Both have masses < 0.25 Msun and effective temperatures below 10,000 K, establishing these putatively He-core WDs as a cooler class of pulsating hydrogen-atmosphere WDs (DAVs, or ZZ Ceti stars). The short-period pulsations evidenced in the light curve of J1112 may also represent the first observation of acoustic (p-mode) pulsations in any WD, which provide an exciting opportunity to probe this WD in a complimentary way compared to the long-period g-modes also present. J1112 is a Teff = 9590 +/- 140 K and log(g) = 6.36 +/- 0.06 WD. The star displays sinusoidal variability at five distinct periodicities between 1792-2855 s. In this star we also see short-period variability, strongest at 134.3 s, well short of expected g-modes for such a low-mass WD. The other new pulsating WD, J1518, is a Teff = 9900 +/- 140 K and log(g) = 6.80 +/- 0.05 WD. The light curve of J1518 is highly non-sinusoidal, with at least seven significant periods between 1335-3848 s. Consistent with the expectation that ELM WDs must be formed in binaries, these two new pulsating He-core WDs, in addition to the prototype SDSS J184037.78+642312.3, have close companions. However, the observed variability is inconsistent with tidally induced pulsations and is so far best explained by the same hydrogen partial-ionization driving mechanism at work in classic C/O-core ZZ Ceti stars.Comment: 9 pages, 5 figures, accepted to The Astrophysical Journa

Measurements of tidal flow variability in Ramsey Sound, Pembrokeshire

The nature of the flow at in-stream tidal energy sites is particularly important for predicting array and device performance, and also for operations and maintenance planning. Previous developers have reported issues such as the choice of vessel, cost of operations, and the limits of operation of deployment vessels. The dynamics of the flow around slack water has been of particular interest at Ramsey Sound in Pembrokeshire (UK) for planning the recovery of an existing turbine, the Tidal Energy Limited ‘Deltastream’. This research presents flow characteristics of Ramsey Sound, based on analysis of Acoustic Doppler Current Profiler (ADCP) measurements and tide gauge data from the nearby Standard Port of Milford Haven. The ADCP was located approximately 300 m across the channel, at the northern end of the channel, where the channel width was 1200 m and the mean depth was approximately 33 m. The flow dynamics were examined specifically to look at times potentially suitable for offshore operations Two weeks of data were used in the analysis, spanning a complete spring-neap cycle. Results demonstrate that flow velocities exhibited clear asymmetry, with stronger flows on the northerly directed flood tide than on the ebb. There was considerable variation in the measured current speed around the time of the maximum, suggesting large scale bed feature generated turbulence. The flood (northerly) current maximum was approximately in phase with high water at Milford Haven. Cross correlation indicated that the flow generally led the elevation by 20 minutes. In contrast to the expected theory, the current strength at mid-depth was stronger than at the surface on the maximum flood tide. The maximum flow speed in the tide was reasonably predictable from the tide range at Milford. A threshold-based analysis of the ADCP measurements allowed the duration of slow-moving water to be identified for operation planning. Operations and planning in light of sound understanding of hydrodynamics at tidal energy sites is critical for future economic success of the tidal energy sector. The results shown here from an ADCP deployment in Ramsey Sound have shown the capability to give useful tools for planning recovery operations

Discovery of an ultramassive pulsating white dwarf

We announce the discovery of the most massive pulsating hydrogen-atmosphere (DA) white dwarf (WD) ever discovered, GD 518. Model atmosphere fits to the optical spectrum of this star show it is a 12,030 +/- 210 K WD with a log(g) = 9.08 +/- 0.06, which corresponds to a mass of 1.20 +/- 0.03 Msun. Stellar evolution models indicate that the progenitor of such a high-mass WD endured a stable carbon-burning phase, producing an oxygen-neon-core WD. The discovery of pulsations in GD 518 thus offers the first opportunity to probe the interior of a WD with a possible oxygen-neon core. Such a massive WD should also be significantly crystallized at this temperature. The star exhibits multi-periodic luminosity variations at timescales ranging from roughly 425-595 s and amplitudes up to 0.7%, consistent in period and amplitude with the observed variability of typical ZZ Ceti stars, which exhibit non-radial g-mode pulsations driven by a hydrogen partial ionization zone. Successfully unraveling both the total mass and core composition of GD 518 provides a unique opportunity to investigate intermediate-mass stellar evolution, and can possibly place an upper limit to the mass of a carbon-oxygen-core WD, which in turn constrains SNe Ia progenitor systems.Comment: 5 pages, 3 figures, Astrophysical Journal Letters, 771, L2 (2013

Radius constraints from high-speed photometry of 20 low-mass white dwarf binaries

We carry out high-speed photometry on 20 of the shortest-period, detached white dwarf binaries known and discover systems with eclipses, ellipsoidal variations (due to tidal deformations of the visible white dwarf), and Doppler beaming. All of the binaries contain low-mass white dwarfs with orbital periods less than 4 hr. Our observations identify the first eight tidally distorted white dwarfs, four of which are reported for the first time here, which we use to put empirical constraints on the mass-radius relationship for extremely low-mass (<0.30 Msun) white dwarfs. We also detect Doppler beaming in several of these binaries, which confirms the high-amplitude radial-velocity variability. All of these systems are strong sources of gravitational radiation, and long-term monitoring of those that display ellipsoidal variations can be used to detect spin-up of the tidal bulge due to orbital decay.Comment: 14 pages, 5 figures, accepted for publication in The Astrophysical Journa

Patients\u27 knowledge and beliefs concerning gout and its treatment: a population based study

BACKGROUND: For patients to effectively manage gout, they need to be aware of the impact of diet, alcohol use, and medications on their condition. We sought to examine patients\u27 knowledge and beliefs concerning gout and its treatment in order to identify barriers to optimal patient self-management. METHODS: We identified patients (\u3e/=18 years of age) cared for in the setting of a multispecialty group practice with documentation of at least one health care encounter associated with a gout diagnosis during the period 2008-2009 (n = 1346). Patients were sent a questionnaire assessing knowledge with regard to gout, beliefs about prescription medications used to treat gout, and trust in the physician. Administrative electronic health records were used to identify prescription drug use and health care utilization. RESULTS: Two hundred and forty patients returned surveys out of the 500 contacted for participation. Most were male (80%), white (94%), and aged 65 and older (66%). Only 14 (6%) patients were treated by a rheumatologist. Only a minority of patients were aware of common foods known to trigger gout (e.g., seafood [23%], beef [22%], pork [7%], and beer [43%]). Of those receiving a urate-lowering medication, only 12% were aware of the short-term risks of worsening gout with initiation. These deficits were more common in those with active as compared to inactive gout. CONCLUSION: Knowledge deficits about dietary triggers and chronic medications were common, but worse in those with active gout. More attention is needed on patient education on gout and self-management training

Hydroxychloroquine and the risk of respiratory infections among RA patients

OBJECTIVES: To determine the effect of hydroxychloroquine on the incidence of new respiratory infections in a large registry of rheumatoid arthritis (RA) patients compared with a matched cohort receiving other conventional disease-modifying antirheumatic drugs (csDMARDs). METHODS: We reviewed physician-reported infections including upper respiratory infections (URI), bronchitis and pneumonia in the Corrona RA registry from June 2008 to February 2020 with the goal of comparing infections in biologic/targeted synthetic (b/ts) DMARDs naive HCQ starts compared with starts of other csDMARDs and no HCQ. Patients on different interventions were compared using time-varying adjusted Cox models adjusting for age, sex, duration of RA, BMI, disease activity, smoking status, concurrent medications, season of the year, year of onset and history of serious infections, diabetes or cardiovascular disease (CVD). A secondary analysis in a set of propensity-matched starts were also compared adjusting for time-varying covariates. The analysis was repeated including URI and bronchitis only and also for serious respiratory infections only. RESULTS: No evidence of differences was found in the incidence of any respiratory infection (URI, bronchitis, pneumonia) in patients receiving HCQ compared with other csDMARDs: HR=0.87 (0.70 to1.07) in adjusted analyses and HR=0.90 (0.70 to 1.17) in adjusted matched analysis. Similar results were found in the analysis of URI and bronchitis only and for serious respiratory infections only. CONCLUSIONS: In patients with RA, the risk for respiratory infections was similar among patients using HCQ as compared to other non-biologic DMARDs

Differential vascular dysfunction in response to diets of differing macronutrient composition: a phenomenonological study

<p>Abstract</p> <p>Background</p> <p>Vascular dysfunction can develop from consumption of an energy-rich diet, even prior to the onset of obesity. However, the roles played by different dietary components remain uncertain. While attempting to develop models of obesity in a separate study, we observed that two high-energy diets of differing macronutrient compositions affected vascular function differently in overweight rats.</p> <p>Methods</p> <p>Male Wistar rats (<it>n </it>= 6/group) were fed diets providing varying percentages of energy from fat and carbohydrate (CHO). For 10 weeks, they were fed either chow, as control diet (10% of energy from fat; 63% from CHO), chow supplemented with chocolate biscuit (30% fat; 56% CHO) or a high-fat diet (45% fat; 35% CHO). Blood concentrations of biochemical markers of obesity were measured, and epididymal fat pads weighed as a measure of adiposity. Mesenteric arteries were dissected and their contractile and relaxant properties analysed myographically. Data were tested by analysis of variance (ANOVA).</p> <p>Results</p> <p>Weight gain and plasma concentrations of glucose, insulin and leptin were similar in all groups. However, biscuit-fed animals showed increased food intake (+27%; <it>p </it>< 0.01) and elevated concentrations of TGs and NEFAs (+41% and +17%; both <it>p </it>< 0.05). High-fat-fed animals showed an increase only in NEFAs (+38%; <it>p </it>< 0.01). Arterial vasoconstriction in response to NA and KCl increased only in biscuit-fed rats (both <it>p </it>< 0.01), while vasorelaxation in response to CCh and SNP, but not histamine, was attenuated in both groups (both <it>p </it>< 0.01). Furthermore, whereas the effect of the high-fat diet was most pronounced in endothelium-dependent vasorelaxation, the biscuit diet had the greater effect on endothelium-independent vasorelaxation.</p> <p>Conclusion</p> <p>Vascular dysfunction resulting from consumption of a high-fat or combined relatively high-fat/high-CHO diet occurs through different physiological processes, which may be attributable to their differing macronutrient compositions. Combining potentially atherogenic macronutrients induces more extensive vascular impairment than that of high-fat alone, and may be attributable to the more marked dyslipidaemia observed with such a diet. Thus, these findings help clarify the role of dietary components in vascular impairment, which has implications for clinical approaches to preventing cardiovascular disease.</p