Gamma-Ray Bursts and the Cosmic Star Formation Rate

We have tested several models of GRB luminosity and redshift distribution functions for compatibility with the BATSE 4B number versus peak flux relation. Our results disagree with recent claims that current GRB observations can be used to strongly constrain the cosmic star formation history. Instead, we find that relaxing the assumption that GRBs are standard candles renders a very broad range of models consistent with the BATSE number-flux relation. We explicitly construct two sample distributions, one tracing the star formation history and one with a constant comoving density. We show that both distributions are compatible with the observed fluxes and redshifts of the bursts GRB970508, GRB971214, and GRB980703, and we discuss the measurements required to distinguish the two models.Comment: 12 pages, 2 postscript figures, uses AAS LaTex macros v4.0. To be published in Astrophysical Journal Letters, accepted August 20, 1998. Revised for publicatio

GALEX and Optical Light Curves of EF Eridanus During a Low State: the Puzzling Source of UV Light

Low state optical photometry of EF Eri during an extended low accretion state combined with GALEX near and far UV time-resolved photometry reveals a source of UV flux that is much larger than the underlying 9500K white dwarf, and that is highly modulated on the orbital period. The near UV and optical light curves can be modeled with a 20,000K spot but no spot model can explain both the large amplitude FUV variations and the SED. The limitations of limb darkening, cyclotron and magnetic white dwarf models in explaining the observations are discussed.Comment: 10 pages, 4 figures to be published in ApJ Letter

Washing practices on the microflora on Georgia-grown cantaloupes.

In recent years, several foodborne illness outbreaks have been associated with the consumption of cantaloupe. Cantaloupes can be contaminated with pathogens anywhere from the field to the packing line. In the United States, cantaloupes are handled and packed differently in each state. Georgia-grown cantaloupes are brought to sheds, washed, and packed, whereas California-grown cantaloupes are field packed. In this study, the microbiological status of cantaloupes produced by four Georgia growers that use various washing and packing practices was assessed to determine the influence of these different practices. The facilities were visited four times during the harvest season. Aerobic bacteria, Escherichia coli, and coliforms on these Georgia-grown cantaloupes were enumerated in transport trailers, after washing, and after packing. Samples also were analyzed for the presence of Salmonella and E. coli O157:H7. In sheds 1 and 4, a chlorinated dump tank was used to wash melons. In sheds 2 and 3, heated water with chlorine was used in the dump tanks. Although there was a significant reduction (P0.05) in the populations of the aerobic bacteria and E. coli between the transport trailer and the dump tank for sheds 1 and 4, the reduction was less than 0.5 log CFU/cm2. The temperatures of the water in the dump tanks at sheds 2 and 3 were not high enough to effectively reduce the microbial populations evaluated. Populations on the melons increased slightly (0.5 log CFU/cm2) after the melons were removed from the dump tank, suggesting possible contamination after washing

Using Simulation to Improve Medical Students' Comfort with Selected Pediatric Procedures

BACKGROUND: Simulation in pediatrics is described often in more procedurally-heavy areas, such as in intensive care, emergency medicine, and neonatology. However, there is a paucity of literature related to simulation in general pediatrics. We sought to improve students’ comfort with and knowledge about selected procedures using simulation mannequins during their pediatric rotation. METHODS: During a workshop, third year medical students received a lecture on male circumcisions, lumbar punctures, the Ortolani and Barlow maneuvers, and ear examinations. Following the lecture, the students were given hands-on instruction and feedback on the techniques for performing ear and hip exams, lumbar punctures, and circumcisions. Students took a pre- and post-encounter assessment regarding their confidence level, procedural knowledge, and perceived usefulness of the training. Wilcoxon Signed Rank tests were used to determine changes in the students’ confidence levels and knowledge. Alpha was set at 0.05 for all comparisons. RESULTS: Sixty medical students (100%) participated in the study during the 2012/2013 academic year. Confidence and knowledge increased significantly on all procedures following the simulation experience (p < 0.001). Perception of usefulness of the training also increased significantly at post-test (p = 0.019). CONCLUSION: Medical students benefited from using simulation to demonstrate and practice common pediatric procedures, both in their confidence and knowledge. The use of simulation for general pediatric procedures should improve patient safety, as well as remove some of the anxiety of performing procedures in actual clinical scenarios

Experimentally verified parameter sets for modelling heterogeneous neocortical pyramidal-cell populations

Models of neocortical networks are increasingly including the diversity of excitatory and inhibitory neuronal classes. Significant variability in cellular properties are also seen within a nominal neuronal class and this heterogeneity can be expected to influence the population response and information processing in networks. Recent studies have examined the population and network effects of variability in a particular neuronal parameter with some plausibly chosen distribution. However, the empirical variability and covariance seen across multiple parameters are rarely included, partly due to the lack of data on parameter correlations in forms convenient for model construction. To addess this we quantify the heterogeneity within and between the neocortical pyramidal-cell classes in layers 2/3, 4, and the slender-tufted and thick-tufted pyramidal cells of layer 5 using a combination of intracellular recordings, single-neuron modelling and statistical analyses. From the response to both square-pulse and naturalistic fluctuating stimuli, we examined the class-dependent variance and covariance of electrophysiological parameters and identify the role of the h current in generating parameter correlations. A byproduct of the dynamic I-V method we employed is the straightforward extraction of reduced neuron models from experiment. Empirically these models took the refractory exponential integrate-and-fire form and provide an accurate fit to the perisomatic voltage responses of the diverse pyramidal-cell populations when the class-dependent statistics of the model parameters were respected. By quantifying the parameter statistics we obtained an algorithm which generates populations of model neurons, for each of the four pyramidal-cell classes, that adhere to experimentally observed marginal distributions and parameter correlations. As well as providing this tool, which we hope will be of use for exploring the effects of heterogeneity in neocortical networks, we also provide the code for the dynamic I-V method and make the full electrophysiological data set available

Contact and Friction of Nano-Asperities: Effects of Adsorbed Monolayers

Molecular dynamics simulations are used to study contact between a rigid, nonadhesive, spherical tip with radius of order 30nm and a flat elastic substrate covered with a fluid monolayer of adsorbed chain molecules. Previous studies of bare surfaces showed that the atomic scale deviations from a sphere that are present on any tip constructed from discrete atoms lead to significant deviations from continuum theory and dramatic variability in friction forces. Introducing an adsorbed monolayer leads to larger deviations from continuum theory, but decreases the variations between tips with different atomic structure. Although the film is fluid, it remains in the contact and behaves qualitatively like a thin elastic coating except for certain tips at high loads. Measures of the contact area based on the moments or outer limits of the pressure distribution and on counting contacting atoms are compared. The number of tip atoms making contact in a time interval grows as a power of the interval when the film is present and logarithmically with the interval for bare surfaces. Friction is measured by displacing the tip at a constant velocity or pulling the tip with a spring. Both static and kinetic friction rise linearly with load at small loads. Transitions in the state of the film lead to nonlinear behavior at large loads. The friction is less clearly correlated with contact area than load.Comment: RevTex4, 17 pages, 13 figure

Li zoning in zircon as a potential geospeedometer and peak temperature indicator

Zircon Li concentrations and δ[superscript 7]Li values may potentially trace crustal recycling because continental and mantle-derived zircons yield distinct values. The usefulness of these differences may depend upon the retentivity of zircon to Li concentrations and isotopic ratios. Given the relatively high Li diffusivities measured by Cherniak and Watson (Contrib Mineral Petrol 160: 383–390, 2010), we sought to discover the scenarios under which Li mobility might be inhibited by charge-compensating cations. Toward this end, we conducted “in” diffusion experiments in which Li depth profiles of synthetic Lu-doped, P-doped, and undoped zircon were determined by nuclear reaction analysis. In separate experiments, Li was ion-implanted at depth within polished natural zircon slabs to form a Gaussian Li concentration profile. Diffusively relaxed concentration profiles were measured after heating the slabs to determine diffusivities. In all experiments, which ranged from 920 to 650 °C, calculated diffusivities are in agreement with a previously established Arrhenius relationship calibrated on trace-element-poor Mud Tank zircon. Our revised Arrhenius relationship that includes both datasets is: D[subscript Li] = 9.60 x 10[superscript -7] exp [-278 ± 8 kJ mol[superscript - 1]/RT] m[superscript 2] s[superscript - 1] We also observed that synthetic sector-zoned zircon exhibits near-step-function Li concentration profiles across sectors that correlate with changes in the rare earth element (REE) and P concentrations. This allowed us to examine how Li diffusion might couple with REE diffusion in a manner different than that described above. In particular, re-heating these grains revealed significant Li migration, but no detectable migration of the rare earth elements. Thus, unlike most elements in zircon which are not mobile at the micrometer scale under most time–temperature paths in the crust, Li zoning, relaxation of zoning, or lack of zoning altogether could be used to reveal time–temperature information. Discrete ~10 μm concentration zones of Li within zircon may be partially preserved at 700 °C for tens to hundreds of years, and at 450 °C for millions of years. In this regard, Li zoning in zircon holds significant potential as a geospeedometer, and in some instances as a qualitative indicator of the maximum temperature experienced by the zircon

Tectonic evolution of the early Mesozoic blueschist-bearing Qiangtang metamorphic belt, central Tibet

This is the published version. Copyright 2003 American Geophysical Union. All Rights Reserved.A >500-km-long east-west trending metamorphic belt in the Qiangtang terrane of central Tibet consists of tectonic melange that occurs in the footwalls of Late Triassic–Early Jurassic domal low-angle normal faults. The melange is comprised of a strongly deformed matrix of metasedimentary and mafic schists that encloses lesser-deformed blocks of metabasites, Carboniferous–Triassic metasedimentary rocks, and early Paleozoic gneiss. Both the blocks and melange matrix exhibit greenschist, epidote-blueschist, and locally, epidote-amphibolite facies mineral assemblages. Thermobarometry reveals that the metamorphic belt experienced pressures of >10 kbar. Maximum equilibration temperatures for mafic schists in the melange matrix decrease from east to west, from ∼660°C near Shuang Hu (33°N, 89°E), ∼500°C near Rongma (33°N, 87°E), to ∼425°C near Gangma Co (34°N, 84°E). Equilibration at consistently high pressures over a large range of temperatures is compatible with metamorphism of Qiangtang melange within a low-angle subduction zone beneath a continental margin. Coupled structural, thermobarometric, and 40Ar/39Ar studies suggest that Qiangtang melange was exhumed in an intracontinental setting from depths of >35 km to upper crustal levels in <12 Myr by Late Triassic–Early Jurassic crustal-scale normal faulting. Detrital zircons from metasandstones within the melange matrix yield U-Pb ion-microprobe ages that range from early Paleozoic to Early Archean, and could have been sourced from terranes to the north of the Jinsha suture. Our results support a model in which Qiangtang melange was underthrust ∼200 km beneath the Qiangtang terrane during early Mesozoic flat-slab southward subduction of Paleo-Tethyan oceanic lithosphere along the Jinsha suture. This model predicts that significant portions of the central Tibetan continental mantle lithosphere were removed during early Mesozoic low-angle oceanic subduction and that the present-day central Tibetan deeper crust includes large volumes of underthrust early Mesozoic melange

Primary accumulation in the Soviet transition

The Soviet background to the idea of primary socialist accumulation is presented. The mobilisation of labour power and of products into public sector investment from outside are shown to have been the two original forms of the concept. In Soviet primary accumulation the mobilisation of labour power was apparently more decisive than the mobilisation of products. The primary accumulation process had both intended and unintended results. Intended results included bringing most of the economy into the public sector, and industrialisation of the economy as a whole. Unintended results included substantial economic losses, and the proliferation of coercive institutions damaging to attainment of the ultimate goal - the building of a communist society

Intracellular soluble α-synuclein oligomers reduce pyramidal cell excitability

The presynaptic protein α-synuclein (αSyn) aggregates during Parkinson's disease (PD) to form large proteinaceous amyloid plaques, the spread of which throughout the brain clinically defines the severity of the disease. During early stages of aggregation, αSyn forms soluble annular oligomers that show greater toxicity than much larger fibrils. These oligomers produce toxicity via a number of possible mechanisms, including the production of pore-forming complexes that permeabilize membranes. In the present study, two well-defined species of soluble αSyn oligomers were produced by different protocols: by polymerization of monomer and by sonication of fibrils. The two oligomeric species produced were morphologically similar, with both having an annular structure and consisting of approximately the same number of monomer subunits, although they differed in their secondary structure. Oligomeric and monomeric αSyn were injected directly into the soma of pyramidal neurons in mouse neocortical brain slices during whole-cell patch clamp recording. Using a combined experimental and modelling approach, neuronal parameters were extracted to measure, for the first time in the neocortex, specific changes in neuronal electrophysiology. Both species of oligomer had similar effects: (i) a significant reduction in input resistance and the membrane time constant and (ii) an increase in the current required to trigger an action potential with a resultant reduction in the firing rate. Differences in oligomer secondary structure appeared to produce only subtle differences in the activity of the oligomers. Monomeric αSyn had no effect on neuronal parameters, even at high concentrations. The oligomer-induced fall in neuronal excitability has the potential to impact both network activity and cognitive processing