445 research outputs found
Understanding the Doctoral Capstone Coordinator Position: A Unique Faculty Role in Occupational Therapy Education
The doctoral capstone coordinator (DCC) position is a required faculty position in U.S. entry-level OTD programs, but there is limited information about this role. This descriptive study aimed to explore the demographics of DCCs; their required workload, tasks, and responsibilities; and the supports available to DCCs. The researchers administered an online survey and analyzed the data using descriptive statistics and content analysis. The results revealed much variability in DCCs’ experiences, workloads, and responsibilities across OTD programs. Of the DCCs survey, 74.0% previously held leadership positions in academia or clinical practice before taking the role, and 60.5% of the DCCs worked overtime for at least half of the previous year. Approximately half of the DCCs spent different percentages of time on teaching, research, service, and clinical responsibilities than expected by their universities. Common capstone tasks completed only by the DCC involved educating others about the capstone process, developing and evaluating the capstone processes, and teaching capstone courses. Tasks commonly completed with support include ensuring student completion of preparatory requirements, securing placements and affiliation agreements, and advising students. The responses varied regarding the individuals involved with mentoring and student assessment responsibilities. Overall, 67.7% of the DCCs were slightly to extremely satisfied with their existing workload
Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients
Major depressive disorder (MDD) is a leading cause of disability worldwide and results tragically in the loss of almost one million lives in Western societies every year. This is due to poor understanding of the disease pathophysiology and lack of empirical medical tests for accurate diagnosis or for guiding antidepressant treatment strategies. Here, we have used shotgun proteomics in the analysis of post-mortem dorsolateral prefrontal cortex brain tissue from 24 MDD patients and 12 matched controls. Brain proteomes were pre-fractionated by gel electrophoresis and further analyzed by shotgun data-independent label-free liquid chromatography-mass spectrometry. This led to identification of distinct proteome fingerprints between MDD and control subjects. Some of these differences were validated by Western blot or selected reaction monitoring mass spectrometry. This included proteins associated with energy metabolism and synaptic function and we also found changes in the histidine triad nucleotide-binding protein 1 (HINT1), which has been implicated recently in regulation of mood and behavior. We also found differential proteome profiles in MDD with (n=11) and without (n=12) psychosis. Interestingly, the psychosis fingerprint showed a marked overlap to changes seen in the brain proteome of schizophrenia patients. These findings suggest that it may be possible to contribute to the disease understanding by distinguishing different subtypes of MDD based on distinct brain proteomic profiles
Bidirectional alterations in brain temperature profoundly modulate spatiotemporal neurovascular responses in-vivo
Neurovascular coupling (NVC) is a mechanism that, amongst other known and latent critical functions, ensures activated brain regions are adequately supplied with oxygen and glucose. This biological phenomenon underpins non-invasive perfusion-related neuroimaging techniques and recent reports have implicated NVC impairment in several neurodegenerative disorders. Yet, much remains unknown regarding NVC in health and disease, and only recently has there been burgeoning recognition of a close interplay with brain thermodynamics. Accordingly, we developed a novel multi-modal approach to systematically modulate cortical temperature and interrogate the spatiotemporal dynamics of sensory-evoked NVC. We show that changes in cortical temperature profoundly and intricately modulate NVC, with low temperatures associated with diminished oxygen delivery, and high temperatures inducing a distinct vascular oscillation. These observations provide novel insights into the relationship between NVC and brain thermodynamics, with important implications for brain-temperature related therapies, functional biomarkers of elevated brain temperature, and in-vivo methods to study neurovascular coupling
Net Charge on a Noble Gas Atom Adsorbed on a Metallic Surface
Adsorbed noble gas atoms donate (on the average) a fraction of an electronic
charge to the substrate metal. The effect has been experimentally observed as
an adsorptive change in the electronic work function. The connection between
the effective net atomic charge and the binding energy of the atom to the metal
is theoretically explored.Comment: ReVvTeX 3.1 format, Two Figures, Three Table
Pulsed Magnetic Field Measurements of the Composite Fermion Effective Mass
Magnetotransport measurements of Composite Fermions (CF) are reported in 50 T
pulsed magnetic fields. The CF effective mass is found to increase
approximately linearly with the effective field , in agreement with our
earlier work at lower fields. For a of 14 T it reaches , over 20
times the band edge electron mass. Data from all fractions are unified by the
single parameter for all the samples studied over a wide range of
electron densities. The energy gap is found to increase like at
high fields.Comment: Has final table, will LaTeX without error
Disc polarization from both emission and scattering of magnetically aligned grains: the case of NGC 1333 IRAS 4A1
Stars and planetary system
Heavy-quark mass dependence in global PDF analyses and 3- and 4-flavour parton distributions
We study the sensitivity of our recent MSTW 2008 NLO and NNLO PDF analyses to
the values of the charm- and bottom-quark masses, and we provide additional
public PDF sets for a wide range of these heavy-quark masses. We quantify the
impact of varying m_c and m_b on the cross sections for W, Z and Higgs
production at the Tevatron and the LHC. We generate 3- and 4-flavour versions
of the (5-flavour) MSTW 2008 PDFs by evolving the input PDFs and alpha_S
determined from fits in the 5-flavour scheme, including the eigenvector PDF
sets necessary for calculation of PDF uncertainties. As an example of their
use, we study the difference in the Z total cross sections at the Tevatron and
LHC in the 4- and 5-flavour schemes. Significant differences are found,
illustrating the need to resum large logarithms in Q^2/m_b^2 by using the
5-flavour scheme. The 4-flavour scheme is still necessary, however, if cuts are
imposed on associated (massive) b-quarks, as is the case for the experimental
measurement of Z b bbar production and similar processes.Comment: 40 pages, 11 figures. Grids can be found at
http://projects.hepforge.org/mstwpdf/ and in LHAPDF V5.8.4. v2: version
published in EPJ
Midlife stress alters memory and mood-related behaviors in old age: role of locally activated glucocorticoids
Origin and Evolution of Saturn's Ring System
The origin and long-term evolution of Saturn's rings is still an unsolved
problem in modern planetary science. In this chapter we review the current
state of our knowledge on this long-standing question for the main rings (A,
Cassini Division, B, C), the F Ring, and the diffuse rings (E and G). During
the Voyager era, models of evolutionary processes affecting the rings on long
time scales (erosion, viscous spreading, accretion, ballistic transport, etc.)
had suggested that Saturn's rings are not older than 100 My. In addition,
Saturn's large system of diffuse rings has been thought to be the result of
material loss from one or more of Saturn's satellites. In the Cassini era, high
spatial and spectral resolution data have allowed progress to be made on some
of these questions. Discoveries such as the ''propellers'' in the A ring, the
shape of ring-embedded moonlets, the clumps in the F Ring, and Enceladus' plume
provide new constraints on evolutionary processes in Saturn's rings. At the
same time, advances in numerical simulations over the last 20 years have opened
the way to realistic models of the rings's fine scale structure, and progress
in our understanding of the formation of the Solar System provides a
better-defined historical context in which to understand ring formation. All
these elements have important implications for the origin and long-term
evolution of Saturn's rings. They strengthen the idea that Saturn's rings are
very dynamical and rapidly evolving, while new arguments suggest that the rings
could be older than previously believed, provided that they are regularly
renewed. Key evolutionary processes, timescales and possible scenarios for the
rings's origin are reviewed in the light of tComment: Chapter 17 of the book ''Saturn After Cassini-Huygens'' Saturn from
Cassini-Huygens, Dougherty, M.K.; Esposito, L.W.; Krimigis, S.M. (Ed.) (2009)
537-57
A mitochondrial half-size ABC transporter is involved in cadmium tolerance in Chlamydomonas reinhardtii
Five cadmium-sensitive insertional mutants, all affected at the CDS1 ('cadmium-sensitive 1') locus, have been previously isolated in the unicellular green alga Chlamydomonas reinhardtii. We here describe the cloning of the Cds1 gene (8314 bp with 26 introns) and the corresponding cDNA. The Cds1 gene, strongly induced by cadmium, encodes a putative protein (CrCds1) of 1062 amino acid residues that belongs to the ATM/HMT subfamily of half-size ABC transporters. This subfamily includes both vacuolar HMT-type proteins transporting phytochelatin-cadmium complexes from the cytoplasm to the vacuole and mitochondrial ATM-type proteins involved in the maturation of cytosolic Fe/S proteins. Unlike the Delta sphmt1 cadmium-sensitive mutant of Schizosaccharomyces pombe that lacks a vacuolar HMT-type transporter, the cds1 mutant accumulates a high amount of phytochelatin-cadmium complexes. By epitope tagging, the CrCds1 protein was localized in the mitochondria. Even though mitochondria of cds1 do not accumulate important amounts of 'free' iron, the mutant cells are hypersensitive to high iron concentrations. Our data show for the first time that a mitochondrial ATM-like transporter plays a major role in tolerance to cadmium.Peer reviewe
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