The Dakini Project

This dissertation merges creative writing with scholarship using the novel, The Dakini Project, to provide the subject matter to which the criticism applies. It will focus on the source of mystery format as that codified by Edgar Allan Poe that is later taken in hand by his fellows Arthur Conan Doyle, Raymond Chandler and Dashiell Hammett (as novelists), authors of the hard-boiled American style, and it will use Chaos theory to assess to idea of catastrophe in terms of emergence rather than disintegration. Though the format comes from American beginnings, the scope of the stories discussed here are tangled around a kind of urban angst that takes place in any number of settings and countries. Crime in these stories is born on the ragged edge of modernity where societies in difficult transitions seem to be struggling with the notion of decency on many levels. The detective in these cases is a rule breaker and a systems expert who is tracking what is known as the butterfly effect, the small and undefined movements that grow and create the huge horrible storms. He is an individual who resolves, brings and rescues others from disorder which is a symptom, cause, and the result of crises, but he is also the disaster maker who will send his fellows whirling away into another kind of lost space. An individual who is himself a creature in disarray, this character is a citizen of the system brought to its knees by crime therefore he is as much a part of the confusion he has been tasked with resolving as any other character in these stories. He will solve the mystery, but his resolution will not be a return to a familiar stability as much as an emergence into the foreign territory of a brand new system which in itself will be recognizable as a platform that will not hold for very long because flux, not stability is the order of existence in these stories

Circuit Rider

An historical novel set at the end of the American Civil War focusing on the week between President Lincoln\u27s assassination and John Wilkes Booth\u27s death. The backdrop of the story is comprised of the historical events and political figures that shaped this period in time in America. The plot is also configured around the fictional histories of three young souls, the spirit of a murdered Chinese immigrant girl, and a brother and sister who\u27s home in the Appalachians was destroyed during the war. All three are escaping the devastating consequences of the war and seeking a new start in the Western states. They become personally entangled in the plot to assassinate the president on the way west. The story focuses on the American underclass, the distinctive experiences of the runaways, the impoverished, immigrants, newly freed slaves and those in the criminal class who were also active participants in shaping the recorded history of the United States and as noteworthy as the heroes and villains Americans know by heart. The novel posits that the small dramas have as powerful an effect on the course of American history as do the renowned conflagrations and disasters that become headline news

Chibby cooperates with 14-3-3 to regulate β-catenin subcellular distribution and signaling activity

β-Catenin functions in both cell–cell adhesion and as a transcriptional coactivator in the canonical Wnt pathway. Nuclear accumulation of β-catenin is the hallmark of active Wnt signaling and is frequently observed in human cancers. Although β-catenin shuttles in and out of the nucleus, the molecular mechanisms underlying its translocation remain poorly understood. Chibby (Cby) is an evolutionarily conserved molecule that inhibits β-catenin–mediated transcriptional activation. Here, we identified 14-3-3ε and 14-3-3ζ as Cby-binding partners using affinity purification/mass spectrometry. 14-3-3 proteins specifically recognize serine 20 within the 14-3-3–binding motif of Cby when phosphorylated by Akt kinase. Notably, 14-3-3 binding results in sequestration of Cby into the cytoplasm. Moreover, Cby and 14-3-3 form a stable tripartite complex with β-catenin, causing β-catenin to partition into the cytoplasm. Our results therefore suggest a novel paradigm through which Cby acts in concert with 14-3-3 proteins to facilitate nuclear export of β-catenin, thereby antagonizing β-catenin signaling

Core Beliefs, Self-Perception, and Cognitive Organization in Depressed Adolescents

The relationships between cognitive products (e.g., self-perception) and cognitive structure (or organization) in clinically depressed adolescents and nonpsychiatric controls (average age = 14.68) were examined. Adolescents with major depressive disorder showed significantly higher scores than did controls on the Young Schema Questionnaire domains of Disconnection, Impaired Autonomy, and Impaired Limits. These individuals also demonstrated poorer self-concept than controls on scholastic abilities, social acceptance, athletic competence, physical appearance, job competence, behavioral conduct, and global self-worth, as well as perceptions of limited social networks. The organization of self-referent adjectives was more tightly interconnected for negative content and less interconnected for positive content in depressed adolescents than in nonpsychiatric controls. Specificity of cognitive organization to themes of interpersonal and achievement beliefs/self-perceptions was also found, particularly for positive content. Implications of the findings for the cognitive vulnerability model of depression and future directions are discussed

Preparing Students for Team-Based Care for Vulnerable Populations

Health professionals have an obligation to improve both the health of the individual and the public in a time of scarce resources. The Institute of Medicine (IOM), Healthy People Curriculum Task Force and professional education accreditation standards indicate the need for health care professionals to demonstrate competencies related to community engagement, basic health promotion skills and the ability to work effectively in interprofessional teams. An Interprofessional Course, IPE 413: Developing Care for a Vulnerable Population provides students the opportunity to collaborate to address health needs in cooperation with a community partner. Students work in teams to address the complex health care needs of an individual community member. The one hour elective course is open to students from nursing, occupational therapy, pharmacy, social work, and exercise science. Efforts are underway to explore the possibility of offering this course to medical students. Students are assessed on the knowledge and experience gained through this interprofessional experience using the Team Skills Scale and student reflections. Faculties from each of the disciplines utilize a collaborative model in the instructional design of the course. The content is co-taught and faculty not only role model interprofessional care, but also serve as mentors and resource personnel for the students as they work with their clients

Changes in oxidative stress in response to different levels of energy restriction in obese ponies

The present study evaluated the effect of different levels of energy restriction on metabolic parameters in obese ponies. Relative weight changes, markers of lipid metabolism, and oxidant/antioxidant balance were monitored. Eighteen obese (body condition score≥7/9) Shetland ponies were studied over a 23.5 week trial, divided into 3 periods. First a 4 week adaptation period in which each animal was fed 100% of their maintenance energy requirements needed to maintain stable obese body weight (MERob). Then a 16.5 weeks weight loss period in which ponies were assigned to receive either 100% (control group, CONTROL), 80% (slow weight loss group, SLOW) or 60% (rapid weight loss group, RAPID) of their MERob. During the 3 week end phase period all animals were again fed 100% of their MERob. Relative weight loss was higher in RAPID (P<0.001) compared to SLOW. No linear relationship was found as a doubling in caloric restriction was accompanied with a tripling in weight loss. Relative weight gain afterwards in the end phase period was higher in RAPID (P<0.001) compared to SLOW and CONTROL. During the weight loss period, triacylglycerol and non-esterified fatty acids levels were highest in RAPID, as were α-tocopherol and ferric reducing ability of plasma. After 8 weeks of weight loss, advanced oxidation protein products were higher in RAPID compared to SLOW and CONTROL (P<0.001). In conclusion, the level of energy restriction influences the extent of changes in oxidant/antioxidant balance. Practically, more severe energy restriction regimens may be associated with a greater regain of weight post restriction

To what extent has COVID-19 impacted hard-to-reach energy audiences?

Energy users who don’t participate in efficiency and conservation programmes despite ongoing outreach are often referred to as ‘Hard-to-Reach’ (HTR). These individuals or organisations can include, e.g., low income or vulnerable households; renters; and small businesses. More effectively engaging HTR audiences is key to ensuring everyone benefits equitably from low-carbon energy transitions and related (policy) interventions. This is even more so the case in light of the COVID-19 pandemic, and the ongoing implications for energy use and affordability for the most vulnerable (and newly-vulnerable) members of our society.Within this context, the main purpose of this paper is to explore the extent to which HTR energy audiences have been impacted by COVID-19. Our primary method for this work was a comprehensive, critical literature review and a compilation of official statistics. We also collected survey, interview and focus group data during 2020 COVID-19 pandemic responses in the U.S., UK, NZ and Sweden. The geographical scope is determined by a 3-year project focusing on HTR energy users and implemented in partnership with the User-Centred Energy Systems Technology Collaboration Programme (Users TCP) by the International Energy Agency (IEA). Key findings we highlight and discuss in this paper:● Sweden has taken a different approach to manage COVID-19, yet when it comes to mobility, declines in demand (~25%) have shown relatively similar patterns to countries with stricter measures. ● In the UK, energy debt is growing due to higher domestic consumption arising from lockdown measures and the reduced income of many households. Most households (72%) have increased their energy (monthly gas and electricity bills are up £32) use. In response, 36% are turning thermostats down and 27% limiting lighting.● In the U.S., a survey of 1,000 energy customers found that more than 50% are using more energy, and monitoring their energy use less; 15% reported postponing a utility bill. ● NZ’s model COVID-19 “elimination” response has included housing, financial support, and specific energy payments to date, though unhealthy and unaffordable housing remains a major issue.Whereas the pandemic has exacerbated several elements of the HTR policy discourse (e.g. impacts on vulnerable and/or low-income households), our findings also reveal several opportunities and critical aspects for policy makers, researchers and utilities to identify and engage HTR energy users

Environmental forcing by submarine canyons: Evidence between two closely situated cold-water coral mounds (Porcupine Bank Canyon and Western Porcupine Bank, NE Atlantic)

Within the Porcupine Bank Canyon (NE Atlantic), cold-water coral (CWC) mounds are mostly found clustered along the canyon lip, with individual disconnected mounds occurring nearby on the western Porcupine Bank. Remotely operated vehicle-mounted vibrocoring was utilized to acquire cores from both of these sites. This study is the first to employ this novel method when aiming to precisely sample two closely situated areas. Radiometric ages constrain the records from the early to mid-Holocene (9.1 to 5.6 ka BP). The cores were then subjected to 3D segmented computer tomography to capture mound formation stages. The cores were then further examined using stable isotopes and benthic foraminiferal assemblages, to constrain the paleoenvironmental variation that influenced CWC mound formation of each site. In total, mound aggradation rate in the Porcupine Bank Canyon and western Porcupine Bank was comparable to other Holocene CWC mounds situated off western Ireland. Results derived from multiproxy analysis, show that regional climatic shifts define the environmental conditions that allow positive coral mound formation. In addition, the aggradation rate of coral mounds is higher adjacent to the Porcupine Bank Canyon than on the western Porcupine Bank. Benthic foraminifera assemblages and planktic foraminiferal δ13C reveal that higher quality organic matter is more readily available closer to the canyon lip. As such, we hypothesize that coral mound formation in the region is likely controlled by an interplay between enhanced shelf currents and the existence of the Eastern North Atlantic Water-Mediterranean Outflow Water-Transition Zone. The geomorphology of the canyon promotes upwelling of these water masses that are enriched in particles, including food and sediment supply. The higher availability of these particles support the development and succession of ecological hotspots along the canyon lip and adjacent areas of the seafloor. These observations provide a glimpse into the role that submarine canyons play in influencing macro and micro benthic fauna distributions and highlights the importance of their conservation