Inclination-Independent Galaxy Classification

We present a new method to classify galaxies from large surveys like the Sloan Digital Sky Survey using inclination-corrected concentration, inclination-corrected location on the color-magnitude diagram, and apparent axis ratio. Explicitly accounting for inclination tightens the distribution of each of these parameters and enables simple boundaries to be drawn that delineate three different galaxy populations: Early-type galaxies, which are red, highly concentrated, and round; Late-type galaxies, which are blue, have low concentrations, and are disk dominated; and Intermediate-type galaxies, which are red, have intermediate concentrations, and have disks. We have validated our method by comparing to visual classifications of high-quality imaging data from the Millennium Galaxy Catalogue. The inclination correction is crucial to unveiling the previously unrecognized Intermediate class. Intermediate-type galaxies, roughly corresponding to lenticulars and early spirals, lie on the red sequence. The red sequence is therefore composed of two distinct morphological types, suggesting that there are two distinct mechanisms for transiting to the red sequence. We propose that Intermediate-type galaxies are those that have lost their cold gas via strangulation, while Early-type galaxies are those that have experienced a major merger that either consumed their cold gas, or whose merger progenitors were already devoid of cold gas (the ``dry merger'' scenario).Comment: Accepted for publication in ApJ. 7 pages in emulateap

A Blue Tilt in the Globular Cluster System of the Milky Way-like Galaxy NGC 5170

Here we present HST/ACS imaging, in the B and I bands, of the edge-on Sb/Sc galaxy NGC 5170. Excluding the central disk region region, we detect a 142 objects with colours and sizes typical of globular clusters (GCs). Our main result is the discovery of a `blue tilt' (a mass-metallicity relation), at the 3sigma level, in the metal-poor GC subpopulation of this Milky Way like galaxy. The tilt is consistent with that seen in massive elliptical galaxies and with the self enrichment model of Bailin & Harris. For a linear mass-metallicity relation, the tilt has the form Z ~ L^{0.42 +/- 0.13}. We derive a total GC system population of 600 +/- 100, making it much richer than the Milky Way. However when this number is normalised by the host galaxy luminosity or stellar mass it is similar to that of M31. Finally, we report the presence of a potential Ultra Compact Dwarf of size ~ 6 pc and luminosity M_I ~ -12.5, assuming it is physically associated with NGC 5170.Comment: Accepted for publication in MNRAS, 11 pages, 10 figure

The water mass transformation framework and variability in hurricane activity

Hurricane activity has been higher since 1995 than in the 1970s and 1980s. This rise in activity has been linked to a warming Atlantic. In this study, we consider variability of the volume of water warmer than 26.5 ºC, considered widely to be the temperature threshold crucial to hurricane development. We find the depth of the 26.5 ºC isotherm better correlated with seasonal hurricane counts than SST in the early part of the Atlantic hurricane season in some regions. The volume of water transformed by surface heat fluxes to temperatures above 26.5 ºC is directly calculated using the Water Mass Transformation framework. This volume is compared with the year-to-year changes in the volume of water of this temperature to see how much of the volume can be explained using this calculation. In some years, there is notable correspondence between transformed and observed volume anomalies, but anomalies in other years must be largely associated with other processes, such as the divergence of horizontal heat transport associated with the AMOC. This technique provides evidence that, in a given year, coordinated physical mechanisms are responsible for the build-up of anomalous ocean heat; not only net surface heat exchange but also the convergence of horizontal heat transport from ocean currents, to provide fuel for larger numbers of intense hurricanes

A new approach to high resolution, high contrast electron microscopy of macromolecular block copolymer assemblies

Determining the structure of macromolecular samples is vital for understanding and adapting their function. Transmission electron microscopy (TEM) is widely used to achieve this, but, owing to the weak electron scattering cross-section of carbon, TEM images of macromolecular samples are generally low contrast and low resolution. Here we implement a fast and practically simple routine to achieve high-contrast imaging of macromolecular samples using exit wave reconstruction (EWR), revealing a new level of structural detail. This is only possible using ultra-low contrast supports such as the graphene oxide (GO) used here and as such represents a novel application of these substrates. We apply EWR on GO membranes to study self-assembled block copolymer structures, distinguishing not only the general morphology or nanostructure, but also evidence for the substructure (i.e. the polymer chains) which gives insight into their formation mechanisms and functional properties

Increased SK3 expression in DM1 lens cells leads to impaired growth through a greater calcium-induced fragility

Although cataract is a characteristic feature of myotonic dystrophy type 1 (DM1), little is known of the underlying mechanisms. We generated four lens epithelial cell lines derived from DM1 cataracts and two from age-matched, non-DM cataracts. Small-pool PCR revealed typical large triplet repeat expansions in the DM1 cells. Furthermore, real-time PCR analysis showed reduced SIX5 expression and increased expression of the Ca2+-activated K+ channel SK3 in the DM1 cells. These cells also exhibited longer population doubling times which did not arise through reduced proliferation, but rather increased cell death as shown by increased release of lactate dehydrogenase (LDH). Using 86Rb+ as a tracer for K+, we found no difference in the resting K+ influx or efflux kinetics. In all cases, the ouabain sensitive component of the influx contributed ~50% of the total. However, stimulating internal Ca2+ by exposure to ionomycin not only caused greater stimulation of K+ (86Rb) efflux in the DM1 cells but also induced a higher rate of cell death (LDH assay). Since both the hyper-stimulation of K+ efflux and cell death were reduced by the highly specific SK inhibitor apamin, we suggest that increased expression of SK3 has a critical role in the increased Ca2+-induced fragility in DM1 cells. The present data, therefore, both help explain the lower epithelial cell density previously observed in DM1 cataracts and provide general insights into mechanisms underlying the fragility of other DM1-affected tissues

Comprehensive pharmacogenetic profiling of the epidermal growth factor receptor pathway for biomarkers of response to, and toxicity from, cetuximab

Background Somatic mutations in the epidermal growth factor receptor (EGFR) intracellular signalling pathways predict non-response to cetuximab in the treatment of advanced colorectal cancer (aCRC). We hypothesized that common germline variants within these pathways may also play similar roles. Methods We analysed 54 potentially functional, common, inherited EGFR pathway variants in 815 aCRC patients treated with oxaliplatin-fluoropyrimidine chemotherapy +cetuximab. Primary endpoints were response and skin rash (SR). We had >85% power to detect ORs=1.6 for variants with minor allele frequencies >20%. Results We identified five potential biomarkers for response and four for SR, although none remained significant after correction for multiple testing. Our initial data supported a role for Ser313Pro in PIK3R2 in modulating response to cetuximab - in patients with KRAS wild type CRCs, 36.4% of patients with one allele encoding proline responded, as compared to 71.2% of patients homozygous for alleles encoding serine (OR 0.23, 95% CI 0.09-0.56, P=0.0014) and this association was predictive for cetuximab (Pinteraction=0.017); however, independent replication failed to validate this association. No previously proposed predictive biomarkers were validated. Conclusions Our study highlights the need to validate potential pharmacogenetic biomarkers. We did not find strong evidence for common germline biomarkers of cetuximab response and toxicity

Globular Cluster Systems in Brightest Cluster Galaxies: A Near-Universal Luminosity Function?

We present the first results from our HST Brightest Cluster Galaxy (BCG) survey of seven central supergiant cluster galaxies and their globular cluster (GC) systems. We measure a total of 48000 GCs in all seven galaxies, representing the largest single GC database. We find that a log-normal shape accurately matches the observed luminosity function (LF) of the GCs down to the GCLF turnover point, which is near our photometric limit. In addition, the LF has a virtually identical shape in all seven galaxies. Our data underscore the similarity in the formation mechanism of massive star clusters in diverse galactic environments. At the highest luminosities (log L > 10^7 L_Sun) we find small numbers of "superluminous" objects in five of the galaxies; their luminosity and color ranges are at least partly consistent with those of UCDs (Ultra-Compact Dwarfs). Lastly, we find preliminary evidence that in the outer halo (R > 20 kpc), the LF turnover point shows a weak dependence on projected distance, scaling as L_0 ~ R^-0.2, while the LF dispersion remains nearly constant.Comment: To appear in Astrophysical Journal, December 201

Progress and challenges in coupled hydrodynamic-ecological estuarine modeling

© The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Estuaries and Coasts 39 (2016): 311-332, doi:10.1007/s12237-015-0011-y.Numerical modeling has emerged over the last several decades as a widely accepted tool for investigations in environmental sciences. In estuarine research, hydrodynamic and ecological models have moved along parallel tracks with regard to complexity, refinement, computational power, and incorporation of uncertainty. Coupled hydrodynamic-ecological models have been used to assess ecosystem processes and interactions, simulate future scenarios, and evaluate remedial actions in response to eutrophication, habitat loss, and freshwater diversion. The need to couple hydrodynamic and ecological models to address research and management questions is clear because dynamic feedbacks between biotic and physical processes are critical interactions within ecosystems. In this review, we present historical and modern perspectives on estuarine hydrodynamic and ecological modeling, consider model limitations, and address aspects of model linkage, skill assessment, and complexity. We discuss the balance between spatial and temporal resolution and present examples using different spatiotemporal scales. Finally, we recommend future lines of inquiry, approaches to balance complexity and uncertainty, and model transparency and utility. It is idealistic to think we can pursue a “theory of everything” for estuarine models, but recent advances suggest that models for both scientific investigations and management applications will continue to improve in terms of realism, precision, and accuracy.NKG, ALA, and RPS acknowledge support from the USGS Coastal and Marine Geology Program. DKR gratefully acknowledges support from NSF (OCE-1314642) and NIEHS (1P50-ES021923-01). MJB and JMPV gratefully acknowledge support from NOAA NOS NCCOS (NA05NOS4781201 and NA11NOS4780043). MJB and SJL gratefully acknowledge support from the Strategic Environmental Research and Development Program—Defense Coastal/Estuarine Research Program (RC-1413 and RC-2245)