Tau-aggregation inhibitor therapy for Alzheimer's disease

Article Accepted Date: 9 December 2013 Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.Peer reviewedPublisher PD

Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies

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Minimum requirements and recommendations for a complete vision examination: A survey of requirements and recommendations from state boards of optometry

A definition of a complete vision exam has never been universally acknowledged. Guidelines have been developed by many individual state Boards of Optometry and by the American Optometric Association listing specific requirements or recommendations for a complete vision examination. This study is a compilation of individual state Boards of Optometry\u27s requirements and recommendations for complete vision examinations. Letters were sent to all fifty state Boards of Optometry requesting information regarding their requirements and/or recommendations for complete vision examinations. Thirty-three Boards of Optometry responded with information. Ofthose, twelve have no requirements, three refer directly to the American Optometric Association\u27s guidelines, and eighteen have a range of requirements and/or recommendations. Inconsistencies between state boards are more abundant than areas of agreement in terms of required/recommended procedures. Optometry would benefit from standard guidelines. This would give optometry more professional and legal leverage by virtue of decreasing inconsistencies that exist, increasing overall quality assurance of complete vision examinations, and providing a template for patient care

Tau Aggregation Inhibitor Therapy : An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

ACKNOWLEDGMENTS We thank patients and their caregivers for their participation in the study and are indebted to all the investigators involved in the study, particularly Drs. Douglas Fowlie and Donald Mowat for their helpful contributions to the clinical execution of the study in Scotland. We thank Sharon Eastwood, Parexel, for assistance in preparing initial drafts of the manuscript. We acknowledge constructive comments provided by Professors G. Wilcock and S. Gauthier on drafts of the article. CMW, CRH, and JMDS are officers of, and hold beneficial interests in, TauRx Therapeutics. RTS, PB, KK, and DJW are paid consultants to TauRx Therapeutics. The study was financed entirely by TauRx TherapeuticsPeer reviewedPublisher PD

Delays in Leniency Application: Is There Really a Race to the Enforcer's Door?

This paper studies cartels’ strategic behavior in delaying leniency applications, a take-up decision that has been ignored in the previous literature. Using European Commission decisions issued over a 16-year span, we show, contrary to common beliefs and the existing literature, that conspirators often apply for leniency long after a cartel collapses. We estimate hazard and probit models to study the determinants of leniency-application delays. Statistical tests find that delays are symmetrically affected by antitrust policies and macroeconomic fluctuations. Our results shed light on the design of enforcement programs against cartels and other forms of conspiracy

An Evaluation of the Proposals in the FCC\u27s Intercarrier Compensation Reform Docket Related to Tandem Transit Services

As part of its Intercarrier Compensation Reform Docket, the Federal Communications Commission (FCC) has received many proposals advocating for the adoption of regulations relating to tandem transit services. As transiting affects virtually every carrier in the telecommunications industry, including traditional CLECs, cable telephony providers, wireless carriers, and even traditional ILECs, the industry is sharply divided over which, if any, of those proposals should be adopted. This Article provides an in-depth look at the issues dividing the industry, and the various proposals before the FCC. The Authors then hypothesize that the FCC should follow the lead of several state commissions who have addressed this exact issue and adopt a nationwide policy that would facilitate the continued growth of competition in the tandem transiting market, as this result would best serve consumers, telecommunications providers, and the industry as a whole

Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease

Copyright © 2015, The American Society for Biochemistry and Molecular Biology. Acknowledgements-We thank Drs Timo Rager and Rolf Hilfiker (Solvias, Switzerland) for polymorph analyses.Peer reviewedPublisher PD

Remote sensing of life: Polarimetric signatures of photosynthetic pigments as sensitive biomarkers

We develop a polarimetry-based remote-sensing method for detecting and identifying life forms in distant worlds and distinguishing them from non-biological species. To achieve this we have designed and built a bio-polarimetric laboratory experiment BioPol for measuring optical polarized spectra of various biological and non-biological samples. Here we focus on biological pigments, which are common in plants and bacteria that employ them either for photosynthesis or for protection against reactive oxygen species. Photosynthesis, which provides organisms with the ability to use light as a source of energy, emerged early in the evolution of life on Earth. The ability to harvest such a significant energy resource could likely also develop on habited exoplanets. Thus, we investigate the detectability of biomolecules that can capture photons of particular wavelengths and contribute to storing their energy in chemical bonds. We have carried out laboratory spectropolarimetric measurements of a representative sample of plants containing various amounts of pigments such as chlorophyll, carotenoids and others. We have also measured a variety of non-biological samples (sands, rocks). Using our lab measurements, we have modelled intensity and polarized spectra of Earth-like planets having different surface coverage by photosynthetic organisms, deserted land and ocean, as well as clouds. Our results demonstrate that linearly polarized spectra provide very sensitive and rather unambiguous detection of photosynthetic pigments of various kinds. Our work paves the path towards analogous measurements of microorganisms and remote sensing of microbial ecology on the Earth and of extraterrestrial life on other planets and moons

Achievable rates for the Gaussian quantum channel

We study the properties of quantum stabilizer codes that embed a finite-dimensional protected code space in an infinite-dimensional Hilbert space. The stabilizer group of such a code is associated with a symplectically integral lattice in the phase space of 2N canonical variables. From the existence of symplectically integral lattices with suitable properties, we infer a lower bound on the quantum capacity of the Gaussian quantum channel that matches the one-shot coherent information optimized over Gaussian input states.Comment: 12 pages, 4 eps figures, REVTe