read:write. Digital possibilities for literature

This report was commissioned by the literature department of Arts Council England (ACE) to gather an overview of how companies, organisations and individuals in the commercial and funded sectors are using Web 2.0 to market fiction, poetry and live literature; spot writing talent; guide readers and potential readers; create, share and review writing. In particular the authors were asked to look at: what opportunities digitisation offers to writers, publishers and other literature organisations how funded organisations can achieve greater sustainability/self-sufficiency or lower costs by making use of technology how organisations can develop audiences and increase participation through use of digital media. The report was commissioned at a formative stage of ACE\u27s digital strategy development, so the research was conducted as an iterative process. The bulk of the research was conducted through interviews and desk research, informed by the experience and expertise of Institute personnel. Interviews informed the desk research and vice versa, and the direction and emphasis of the report evolved in a series of meetings with ACE personnel. The core of this report lies in the case studies. After an initial period of Web research and informal discussion with key individuals in the sector, the authors developed a baseline questionnaire covering key areas. These included technology, site maintenance, resourcing and future hopes and needs. Though each organisation interviewed had different needs and priorities, and the interview was adapted accordingly in each case, we used this baseline to identify themes that persisted across different areas. In addition to the interviews, the authors conducted extensive Web-based research covering both UK and international literature organisations. This formed the basis of subsector overviews that combine with the case studies

Identifying Dietary and Migratory Patterns of Illinois Woolly Mammoth Populations Using Isotope Analysis of Carbon, Oxygen, and Strontium

The extinct woolly mammoth (Mammuthus primigenius) ranged from Alaska to the Northeastern Seaboard throughout the Late Pleistocene (100-10 Ka). Although it is recognized that woolly mammoths coincided with and lived in a region heavily influenced by glacial ice sheets, little is known about their dietary or migratory behavior. This study classifies and provides insight into the diet and mobility of Midwestern mammoths by analyzing stable isotopes of carbon, oxygen, and strontium preserved in the tooth enamel of these extinct elephantids. A woolly mammoth tooth from Moline, IL, was bulk-sampled and micromilled to extract the aforementioned isotopes from the base of the enamel. Dated to 16,410 ±110 BP (20,085-19,530 calBP), measured 13C (-12.6‰ to -11.1‰, PDB) values indicate that the terminal LGM landscape of western Illinois was dominated by C3 vegetation, which is typical of a cooler climate. This cooler climate during the LGM is also reflected by the resulting high 18O values (-10.8‰ to -8.1‰, PDB). The ratios of 87Sr/86Sr isotopes retained in the tooth enamel were mapped using GIS onto a regional isoscape to determine the mobility of one mammoth across its lifetime. The mobility patterns were compared to seasonal and annual dietary shifts to better understand the underlying cause for migrations. Preliminary analyses of the 87Sr/86Sr values (0.7907 – 0.7156) suggest that there were regional population movements around the northern Mississippi River Valley. The data reveals the climate and landscape during the terminal Pleistocene in western Illinois and how woolly mammoths responded to it

Novel African trypanocidal agents: membrane rigidifying peptides

The bloodstream developmental forms of pathogenic African trypanosomes are uniquely susceptible to killing by small hydrophobic peptides. Trypanocidal activity is conferred by peptide hydrophobicity and charge distribution and results from increased rigidity of the plasma membrane. Structural analysis of lipid-associated peptide suggests a mechanism of phospholipid clamping in which an internal hydrophobic bulge anchors the peptide in the membrane and positively charged moieties at the termini coordinate phosphates of the polar lipid headgroups. This mechanism reveals a necessary phenotype in bloodstream form African trypanosomes, high membrane fluidity, and we suggest that targeting the plasma membrane lipid bilayer as a whole may be a novel strategy for the development of new pharmaceutical agents. Additionally, the peptides we have described may be valuable tools for probing the biosynthetic machinery responsible for the unique composition and characteristics of African trypanosome plasma membranes

Poorest countries experience earlier anthropogenic emergence of daily temperature extremes

Understanding how the emergence of the anthropogenic warming signal from the noise of internal variability translates to changes in extreme event occurrence is of crucial societal importance. By utilising simulations of cumulative carbon dioxide (CO2) emissions and temperature changes from eleven earth system models, we demonstrate that the inherently lower internal variability found at tropical latitudes results in large increases in the frequency of extreme daily temperatures (exceedances of the 99.9th percentile derived from pre-industrial climate simulations) occurring much earlier than for mid-to-high latitude regions. Most of the world's poorest people live at low latitudes, when considering 2010 GDP-PPP per capita; conversely the wealthiest population quintile disproportionately inhabit more variable mid-latitude climates. Consequently, the fraction of the global population in the lowest socio-economic quintile is exposed to substantially more frequent daily temperature extremes after much lower increases in both mean global warming and cumulative CO2 emissions

Mediastinal node staging by positron emission tomography-computed tomography and selective endoscopic ultrasound with fine needle aspiration for patients with upper gastrointestinal cancer: results from a regional centre

Aim: To investigate the impact of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and positron emission tomography-computed tomography (PET-CT) in the nodal staging of upper gastrointestinal (GI) cancer in a tertiary referral centre. Methods: We performed a retrospective review of prospectively recorded data held on all patients with a diagnosis of upper GI cancer made between January 2009 and December 2015. Only those patients who had both a PET-CT and EUS with FNA sampling of a mediastinal node distant from the primary tumour were included. Using a positive EUS-FNA result as the gold standard for lymph node involvement, the sensitivity, specificity, positive and negative predictive values (PPV and NPV) and accuracy of PET-CT in the staging of mediastinal lymph nodes were calculated. The impact on therapeutic strategy of adding EUS-FNA to PET-CT was assessed. Results: One hundred and twenty one patients were included. Sixty nine patients had a diagnosis of oesophageal adenocarcinoma (Thirty one of whom were junctional), forty eight had oesophageal squamous cell carcinoma and four had gastric adenocarcinoma. The FNA results were inadequate in eleven cases and the PET-CT findings were indeterminate in two cases, therefore thirteen patients (10.7%) were excluded from further analysis. There was concordance between PET-CT and EUS-FNA findings in seventy one of the remaining one hundred and eight patients (65.7%). The sensitivity, specificity, PPV and NPV values of PET-CT were 92.5%, 50%, 52.1% and 91.9% respectively. There was discordance between PET-CT and EUS-FNA findings in thirty seven out of one hundred and eight patients (34.3%). MDT discussion led to a radical treatment pathway in twenty seven of these cases, after the final tumour stage was altered as a direct consequence of the EUS-FNA findings. Of these patients, fourteen (51.9%) experienced clinical remission of a median of nine months (range three to forty two months). Conclusion: EUS-FNA leads to altered staging of upper GI cancer, resulting in more patients receiving radical treatment that would have been the case using PET-CT staging alone

Early Science with the Large Millimeter Telescope: COOL BUDHIES I - a pilot study of molecular and atomic gas at z~0.2

An understanding of the mass build-up in galaxies over time necessitates tracing the evolution of cold gas (molecular and atomic) in galaxies. To that end, we have conducted a pilot study called CO Observations with the LMT of the Blind Ultra-Deep H I Environment Survey (COOL BUDHIES). We have observed 23 galaxies in and around the two clusters Abell 2192 (z = 0.188) and Abell 963 (z = 0.206), where 12 are cluster members and 11 are slightly in the foreground or background, using about 28 total hours on the Redshift Search Receiver (RSR) on the Large Millimeter Telescope (LMT) to measure the $^{12}$CO J = 1 --> 0 emission line and obtain molecular gas masses. These new observations provide a unique opportunity to probe both the molecular and atomic components of galaxies as a function of environment beyond the local Universe. For our sample of 23 galaxies, nine have reliable detections (S/N$\geq$3.6) of the $^{12}$CO line, and another six have marginal detections (2.0 < S/N < 3.6). For the remaining eight targets we can place upper limits on molecular gas masses roughly between $10^9$ and $10^{10} M_\odot$. Comparing our results to other studies of molecular gas, we find that our sample is significantly more abundant in molecular gas overall, when compared to the stellar and the atomic gas component, and our median molecular gas fraction lies about $1\sigma$ above the upper limits of proposed redshift evolution in earlier studies. We discuss possible reasons for this discrepancy, with the most likely conclusion being target selection and Eddington bias.Comment: MNRAS, submitte