Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection

BACKGROUND: Oxidative stress can be defined as an increase in oxidants and/or a decrease in antioxidant capacity. There is limited information about the oxidative status in subjects with hepatitis B virus infection. We aimed to evaluate the oxidative status in patients with various clinical forms of chronic hepatitis B infection. METHODS: Seventy-six patients with hepatitis B virus infection, in whom 33 with chronic hepatitis, 31 inactive carriers and 12 with cirrhosis, and 16 healthy subjects were enrolled. Total antioxidant response and total peroxide level measurement, and calculation of oxidative stress index were performed in all participants. RESULTS: Total antioxidant response was significantly lower in cirrhotics than inactive HbsAg carriers and controls (p = 0.008 and p = 0.008, respectively). Total peroxide level and oxidative stress index was significantly higher in cirrhotic (p < 0.001, both) and chronic hepatitis B subjects (p < 0.001, both) than inactive HbsAg carriers and controls. Total antioxidant response was comparable in chronic hepatitis B subjects, inactive HbsAg carriers and controls (both, p > 0.05/6). Total peroxide level and oxidative stress index were also comparable in inactive HBsAg carriers and controls (both, p > 0.05/6). Serum alanine amino transferase level was positively correlated with total peroxide level and oxidative stress index only in chronic hepatitis B subjects (p = 0.002, r = 0.519 and p = 0.008, r = 0.453, respectively). CONCLUSION: Oxidative stress occurs secondarily to increased total lipid peroxidation and inadequate total antioxidant response and is related to severity of the disease and replication status of virus in hepatitis B infection

Oxidative stress in hepatitis C infected end-stage renal disease subjects

BACKGROUND: Both uremia and hepatitis C infection is associated with increased oxidative stress. In the present study, we aimed to find out whether hepatitis C infection has any impact on oxidative stress in hemodialysis subjects. METHODS: Sixteen hepatitis C (+) hemodialysis subjects, 24 hepatitis C negative hemodialysis subjects and 24 healthy subjects were included. Total antioxidant capacity, total peroxide level and oxidative stress index were determined in all subjects. RESULTS: Total antioxidant capacity was significantly higher in controls than hemodialysis subjects with or without hepatitis C infection (all p < 0.05/3), while total peroxide level and oxidative stress index were significantly lower (all p < 0.05/3). Hepatitis C (-) hemodialysis subjects had higher total antioxidant capacity compared to hepatitis C (+) hemodialysis subjects (all p < 0.05/3). Total peroxide level and oxidative stress index was comparable between hemodialysis subjects with or without hepatitis C infection (p > 0.05/3). CONCLUSION: Oxidative stress is increased in both hepatitis C (+) and hepatitis C (-) hemodialysis subjects. However, hepatitis C infection seems to not cause any additional increase in oxidative stress in hemodialysis subjects and it may be partly due to protective effect of dialysis treatment on hepatitis C infection

ABO blood groups and Rh factor are risk factors for Epithelial Ovarian Cancer?

WOS: 000495991100001Objective(s): The initial aim of this study is to research the allocation of blood types ABO and Rh factor antigens in patients with epithelial ovarian cancer (EOC). Design: Retrospective Setting: University Hospital (Tertiary center) Subjects: From the records at Zonguldak Bulent Ecevit University Faculty of Medicine Hospital in the period January 2010- June 2018, data on 100 EOC patients were obtained concerning blood groups ABO and Rh factor in 90 women. Intervention(s): The control group was constituted from the Zonguldak Bulent Ecevit University Faculty of Medicine Hospital Blood Transfusion Center and included 17065 females, to make reliable comparison, same region-same gender. Main Outcome Measure(s): Blood types ABO and Rh factors, patients having EOC. Result(s): Data on 90 women with EOC and recorded blood types ABO and Rh factors were taken for retrospective analysis. Although, blood type O was seemingly related with higher risk of EOC, this difference was not statistically significant. Also, blood type B was seemingly allocated with low risk of EOC, albeit this difference was not statistically significant. Condusion(s): Most previous studies have reported increased cancer of the ovaries associated with the A blood type compared to the O group. Contrary to our data, Zhang et al found that, blood type O is allocated with lower risk of cancer of the ovaries. Our studies results show possible allocation between the O blood type and higher risk of EOC B blood type and decreased probability EOC

Is there any difference in lateralization in epithelial ovarian cancer cases?

WOS: 000449612300017Introduction: Whether there is a right or left lateralization difference in cancer involvement in double sided organs has become a topic of interest in recent years. In addition, the density of cancer metastasis to the right or left lymph nodes has become a subject of inquisition. Our aim in this study is to retrospectively investigate differences in right- or left-sided ovarian cancer incidence. Materials and methods: In the Gynaecological Oncology Clinic of Zonguldak Bulent Ecevit University, 96 patients with epithelial ovarian cancer who were followed up between 2008 and 2017 were retrospectively noted as having right or left ovarian involvement or a tumour mass with right or left overgrowth. Results and discussion: A prominence of left ovarian involvement was observed in our study results. Especially when patients in the first stage of cancer, FIGO stage 1A, were examined, it was obvious that epithelial ovarian cancer tends to commence in the left ovary rather than the right ovary. Conclusion: There is a need for prospective studies with multidisciplinary studies including immunohistopathology to investigate hypotheses such as hormonal susceptibility, which can be postulated as an explanation for the higher frequency of left vs right ovary involvement in EOC

Microbiological Colonisation of Intrauterin Devices Removed Due to Non- pelvic Inflammatory Disease

Giriş: Pelvik inflamatuar hastalık (PİH) tanısı almayan hastalarda diğer nedenlerle çıkartılan rahim içi araçlar(RİA)da mikrobiyal kolonizasyonunun incelenmesi Gereç ve Yöntemler: Bülent Ecevit Üniversitesi Kadın Hastalıkları ve Doğum Kliniği’ne başvuran pelvik inflamasyon bulguları olmayan 40 hastadan herhangi bir nedenle çıkarılan RİA’ların kültür incelemesi yapıldı. Bulgular: Düzensiz kanama, ağrı veya servikal yerleşim nedeniyle çıkartılan RİA’ların kültür incelemesinde sadece 5 hastada(%12.5) üreme olmuştur. Sonuç: RiA’nın pelvik inflamasyondaki rolü bilinmektedir. Daha önce yapılan çalışmalarda RİA’ların pelvik inflamatuar hastalık oluşturmadan bakteriyel kolonizasyon oluşturduğuna dair veriler vardır. Fakat bizim çalışmamızda PİH tanısı olmayan hastalarda bakteriyel kolonizasyon saptanmamıştır. Burada PİH oluşumunda diğer risk faktörlerinin (erken yaşta başlayan cinsel ilişki, koit sıklığı, hijyen) önemli olabileceği ve coğrafi bölgesel faklılıklar gösterebileceğini dikkate almak gerekir.Aim: To evaluate microbiological colonisation of intrauterin devices (IUDs) in patients without the diagnosis of pelvic inflammatory disease (PID). Material and Methods: The cultures of IUDs of 40 patients, admitted to Bülent Ecevit University Gynecology and Obstetrics Department and had no pelvic infection signs, were evaluated. Results: The culture results of IUDs removed due to abnormal uterine bleeding, pelvic pain, cervical localisation revealed that only 5(12,5%) of patients had microbiological colonisation. Conclusion: The role of IUDs on pelvic infections has been known. The data in the past studies revealed that IUDs cause bacterial colonisation without pelvic inflammatory disease. However, in our study there was no bacteria colonisation in patients without PID. The other risk factors (early sexual function, frequency of coitus, hygien) and geographical regionvariations should be considered as reasons of PID

Prevalence of cervical cytological abnormalities in Turkey

Objective: To evaluate retrospectively the prevalence of cervical cytological abnormalities in patient records obtained from healthcare centers in Turkey. Method: Demographic characteristics and data on cervical cytological abnormalities were evaluated from patients who underwent flap tests in healthcare centers in 2007. Results: Data were collected from 33 healthcare centers totaling 140 334 patients. Overall, the prevalence of cervical cytological abnormalities was 1.8%; the prevalence of ASCUS, ASC-H, LSIL, HSIL, and AGC was 1.07%, 0.07%, 0.3%, 0.17%, and 0.08%, respectively. The prevalence of preinvasive cervical neoplasia was 1.7% and the prevalence of cytologically diagnosed invasive neoplasia was 0.06%. Conclusion: The abnormal cervical cytological prevalence rate in Turkey is lower than in Europe and North America. This might be due to sociocultural differences, lack of population-based screening programs, or a lower HPV prevalence rate in Turkey. (C) 2009 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved