Glial fibrillary acidic protein antibody-positive meningoencephalomyelitis

Glial fibrillary acidic protein antibody-positive meningoencephalomyelitis is a newly described, possibly under-recognised, severe inflammatory condition of the nervous system. The clinical presentation is variable but most commonly is a combination of meningitis, encephalitis and myelitis; other manifestations may include seizures, psychiatric symptoms and tremor. There is a significant association with malignancies, often occult, and with other autoimmune conditions. Although the disease responds well to corticosteroids acutely, it typically relapses when these are tapered, and so patients need long-term immunosuppression. We report a young man presenting with subacute meningoencephalitis and subsequent myelitis, and discuss the typical presentation and management of this severe but treatable condition.</jats:p

Demand response supported energy management framework for residential users

This paper proposes a smart home energy management system (EMS) designed to automatically adjust the energy requirements as per the availability indicator provided by the Distribution Company (DISCO). The system considers bidirectional end-user parameters, comfort values, and thresholds for a typical residential community microgrid. The energy management system formulates an effective strategy by considering user-side comfort, threshold parameters, and utility-side external signals. The utility-side external signal depends on load reduction requests, signal duration, and signal type. The system is tuned according to utility reduction requests to achieve peak load reduction during specific hours, which helps lower overall power consumption. Two main strategies are employed for this purpose. Comfort Value-based Strategy, where the user priority for each appliance is determined based on the comfort value, allowing the system to optimize energy usage while considering user preferences. Power Consumption-based Strategy, which analyzes the appliance power consumption patterns, this strategy is implemented, proving to be the best option for dealing with low-priority signals from the utility grid. The proposed EMS enables utilities to efficiently manage peak power consumption while empowering users to reduce their electricity bills and optimize energy consumption. This integrated approach creates a win-win situation, benefitting both the utility companies and end users in the smart home environment

Characteristics of 698 patients with dissociative seizures: a UK multicenter study

Objective We aimed to characterize the demographics of adults with dissociative (nonepileptic) seizures, placing emphasis on distribution of age at onset, male:female ratio, levels of deprivation, and dissociative seizure semiology. Methods We collected demographic and clinical data from 698 adults with dissociative seizures recruited to the screening phase of the CODES (Cognitive Behavioural Therapy vs Standardised Medical Care for Adults With Dissociative Non‐Epileptic Seizures) trial from 27 neurology/specialist epilepsy clinics in the UK. We described the cohort in terms of age, age at onset of dissociative seizures, duration of seizure disorder, level of socioeconomic deprivation, and other social and clinical demographic characteristics and their associations. Results In what is, to date, the largest study of adults with dissociative seizures, the overall modal age at dissociative seizure onset was 19 years; median age at onset was 28 years. Although 74% of the sample was female, importantly the male:female ratio varied with age at onset, with 77% of female but only 59% of male participants developing dissociative seizures by the age of 40 years. The frequency of self‐reported previous epilepsy was 27%; nearly half of these epilepsy diagnoses were retrospectively considered erroneous by clinicians. Patients with predominantly hyperkinetic dissociative seizures had a shorter disorder duration prior to diagnosis in this study than patients with hypokinetic seizures (P < .001); dissociative seizure type was not associated with gender. Predominantly hyperkinetic seizures were most commonly seen in patients with symptom onset in their late teens. Thirty percent of the sample reported taking antiepileptic drugs; this was more common in men. More than 50% of the sample lived in areas characterized by the highest levels of deprivation, and more than two‐thirds were unemployed. Significance Females with dissociative seizures were more common at all ages, whereas the proportion of males increased with age at onset. This disorder was associated with socioeconomic deprivation. Those with hypokinetic dissociative seizures may be at risk for delayed diagnosis and treatment