T. S. Eliot’s “Burnt Norton”: Past, Present, and Future

Critical interpretations of “Burnt Norton” have varied widely over the nearly 80 years since its first publication. While many early scholars saw it as an abstract meditation on philosophy, the revelation in the 1970s, 1980s, and 1990s of the relationship of Eliot and Emily Hale changed to some extent the way in which it is read, with more of a personal view, at least in its inspiration. Indeed, I suggest that “Burnt Norton” and specifically the rose garden passage presents the two figures in the poem at a moment fraught with the possibility of rekindling their earlier romance. Our knowledge of the subsequent poems and of the failure of the further development of their relationship greatly colors our reading of the poem, preventing us from seeing the tension and suspense of this experience as it balances between the attraction of human love and that of a demanding spiritual commitment

Revisiting Gender And Religion

In this presidential address delivered at the 2014 annual meeting of the Religious Research Association, the topic of religion and gender is revisited by focusing on parallel histories of American Protestant ordained clergywomen and social science scholarship on religion, noting that in both cases we have witnessed extraordinary change, but not transformation

Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma

Synonymous mutations, which do not alter the protein sequence, have been shown to affect protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet 12(10):683–691]. However, synonymous mutations are rarely investigated in the cancer genomics field. We used whole-genome and -exome sequencing to identify somatic mutations in 29 melanoma samples. Validation of one synonymous somatic mutation in BCL2L12 in 285 samples identified 12 cases that harbored the recurrent F17F mutation. This mutation led to increased BCL2L12 mRNA and protein levels because of differential targeting of WT and mutant BCL2L12 by hsa-miR-671–5p. Protein made from mutant BCL2L12 transcript bound p53, inhibited UV-induced apoptosis more efficiently than WT BCL2L12, and reduced endogenous p53 target gene transcription. This report shows selection of a recurrent somatic synonymous mutation in cancer. Our data indicate that silent alterations have a role to play in human cancer, emphasizing the importance of their investigation in future cancer genome studies

Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma

Synonymous mutations, which do not alter the protein sequence, have been shown to affect protein function [Sauna ZE, Kimchi-Sarfaty C (2011) Nat Rev Genet 12(10):683-691]. However, synonymous mutations are rarely investigated in the cancer genomics field. We used whole-genome and -exome sequencing to identify somatic mutations in 29 melanoma samples. Validation of one synonymous somatic mutation in BCL2L12 in 285 samples identified 12 cases that harbored the recurrent F17F mutation. This mutation led to increased BCL2L12 mRNA and protein levels because of differential targeting of WT and mutant BCL2L12 by hsa-miR-671-5p. Protein made from mutant BCL2L12 transcript bound p53, inhibited UV-induced apoptosis more efficiently than WT BCL2L12, and reduced endogenous p53 target gene transcription. This report shows selection of a recurrent somatic synonymous mutation in cancer. Our data indicate that silent alterations have a role to play in human cancer, emphasizing the importance of their investigation in future cancer genome studies