Accessing numeric data via flags and tags: A final report on a real world experiment

An experiment is reported which: extended the concepts of data flagging and tagging to the aerospace scientific and technical literature; generated experience with the assignment of data summaries and data terms by documentation specialists; and obtained real world assessments of data summaries and data terms in information products and services. Inclusion of data summaries and data terms improved users' understanding of referenced documents from a subject perspective as well as from a data perspective; furthermore, a radical shift in document ordering behavior occurred during the experiment toward proportionately more requests for data-summarized items

The identification and psychological treatment of panic disorder in adolescents: a survey of CAMHS clinicians

Background Panic disorder is experienced by around 1% of adolescents, and has a significant impact on social and academic functioning. Preliminary evidence supports the effectiveness of panic disorder specific treatment in adolescents with panic disorder, however panic disorder may be overlooked in adolescents due to overlapping symptoms with other anxiety disorders and other difficulties being more noticeable to others. The aim of this study was to establish what training National Health Service (NHS) Child and Adolescent Mental Health Services (CAMHS) clinicians have received in psychological therapies and panic disorder and how they identify and treat panic disorder in adolescents. Method CAMHS clinicians from a range of professions (n = 427), who were delivering psychological treatments to children and adolescents with anxiety disorders, participated. They completed a cross-sectional, online survey, including a vignette describing an adolescent with panic disorder, and were asked to identify the main diagnosis or presenting problem. Results Less than half the clinicians (48.6%) identified panic disorder or panic symptoms as the main presenting problem from the vignette. The majority of clinicians suggested CBT would be their treatment approach. However, few identified an evidence-based treatment protocol for working with young people with panic disorder. Almost half the sample had received no training in cognitive behaviour therapy (CBT) and around a fifth had received no training in delivering psychological treatments. Conclusions Only half of CAMHS clinicians identified panic disorder from a vignette and although CBT treatments are widely offered, only a minority of adolescents with panic disorder are receiving treatments developed for, and evaluated with young people with panic disorder. There is a vital need for clinician training, the use of tools that aid identification and the implementation of evidence-based treatments within CAMHS

Instructional development of community improvement programs

Across the nation there exists many housing communities that have poorly maintained, run down, and/or vandalized external properties. These communities, although strongly manipulated by the amount of public monies that circulate within them, may not solely be the direct result of such economic influences. But rather, these external living conditions may be the result of a lack of education, organization, and motivation on the part of the people of these communities. This lack of education, organization, and motivation may result in the neglect and poor maintenance of external properties and grounds in such areas as: condemned housing that may be boarded up but not torn down; in-operational vehicles that have been left on city streets; trash and garbage dispersed throughout neighborhoods; overgrown weeds in yards; inadequate maintenance of homes and living facilities (pealing paint, broken drain spouts, and unsafe stairs and exits), and vandalized public and private property

Blast injuries in children: a mixed-methods narrative review.

Background and significance. Blast injuries arising from high explosive weaponry is common in conflict areas. While blast injury characteristics are well recognised in the adults, there is a lack of consensus as to whether these characteristics translate to the paediatric population. Understanding blast injury patterns in this cohort is essential for providing appropriate provision of services and care for this vulnerable cohort. Methods. In this mixed-method review, original papers were screened for data pertaining to paediatric injuries following blasts. Information on demographics, morbidity and mortality and service requirements were evaluated. The papers were written and published in English from a range of international specialists in the field. Patient and public involvement statement: No patients or members of the public were involved in this review. Results. Children affected by blast injuries are predominantly male and their injuries arise from explosive remnants of war, particularly unexploded ordinance. Blasts show increased morbidity and mortality in younger children, while older children have injury patterns similar to adults. Head and burn injuries represent a significant cause of mortality in young children, while lower limb morbidity is reduced compared to adults. Children have a disproportionate requirement for both operative and non-operative service resources, and provisions for this burden are essential. Conclusions. Certain characteristics of paediatric injuries arising from blasts are distinct from that of the adult cohort, while the intensive demands on services highlights the importance of understanding the diverse injury patterns in order to optimise future service provisions in caring for this the child blast survivor

First characterization of a superconducting filter-bank spectrometer for hyper-spectral microwave atmospheric sounding with transition edge sensor readout

We describe the design, fabrication, integration and characterization of a prototype superconducting filter bank with transition edge sensor readout designed to explore millimetre-wave detection at frequencies in the range 40 to 65 GHz. Results indicate highly uniform filter channel placement in frequency and high overall detection efficiency. The route to a full atmospheric sounding instrument in this frequency range is discussed.Centre for Earth Observing Instrumentation UK (CEOI

MetaTel: Ongoing work on a meta-material sub-THz telescope for Earth observing

We report on ongoing technology development activities in the build and testing of a refractive telescope composed of metamaterial Gradient Index (GrIn) lenses based on photolithographic meshes. This concept is tailored for Earth Observation, and more precisely limb-scanning in the sub- THz bands addressing emission lines between 50 and 190 GHz. A single GrIn lens design which includes in-built anti-reflection coating layers, allows us to produce sufficient refraction to allow an optical design of a set of compound lenses to create the first THz range telescope fully composed of metamaterials. First lens prototypes have been built and tested spectrally and spatially and compared to analytical models showing good agreement. Prediction of telescope performance is discussed as well as future developments

The origins of X-ray emission from the hotspots of FRII radio sources

We use new and archival Chandra data to investigate the X-ray emission from a large sample of compact hotspots of FRII radio galaxies and quasars from the 3C catalogue. We find that only the most luminous hotspots tend to be in good agreement with the predictions of a synchrotron self-Compton model with equipartition magnetic fields. At low hotspot luminosities inverse-Compton predictions are routinely exceeded by several orders of magnitude, but this is never seen in more luminous hotspots. We argue that an additional synchrotron component of the X-ray emission is present in low-luminosity hotspots, and that the hotspot luminosity controls the ability of a given hotspot to produce synchrotron X-rays, probably by determining the high-energy cutoff of the electron energy spectrum. It remains plausible that all hotspots are close to the equipartition condition.Comment: 49 pages, 16 figures. ApJ accepted. Revised version fixes a typo in one of the Tables and corrects a statement about 3C27

The Electron Energy Distribution in the Hotspots of Cygnus A: Filling the Gap with the Spitzer Space Telescope

Here we present Spitzer Space Telescope imaging of Cyg A with the Infrared Array Camera, resulting in the detection of the high-energy tails or cut-offs in the synchrotron spectra for all four hotspots of this archetype radio galaxy. When combined with the other data collected from the literature, our observations allow for detailed modeling of the broad-band emission for the brightest spots A and D. We confirm that the X-ray flux detected previously from these features is consistent with the synchrotron self-Compton radiation for the magnetic field intensity 170 muG in spot A, and 270 muG in spot D. We also find that the energy density of the emitting electrons is most likely larger by a factor of a few than the energy density of the hotspots' magnetic field. We construct energy spectra of the radiating ultrarelativistic electrons. We find that for both hotspots A and D these spectra are consistent with a broken power-law extending from at least 100 MeV up to 100 GeV, and that the spectral break corresponds almost exactly to the proton rest energy of 1 GeV. We argue that the shape of the electron continuum reflects two different regimes of the electron acceleration process at mildly relativistic shocks, rather than resulting from radiative cooling and/or absorption effects. In this picture the protons' inertia defines the critical energy for the hotspot electrons above which Fermi-type acceleration processes may play a major role, but below which the operating acceleration mechanism has to be of a different type. At energies >100 GeV, the electron spectra cut-off/steepen again, most likely as a result of spectral aging due to radiative loss effects. We discuss several implications of the presented analysis for the physics of extragalactic jets.Comment: 29 pages, 8 figures and 2 tables included. Accepted for publication in Ap

PILOT: a balloon-borne experiment to measure the polarized FIR emission of dust grains in the interstellar medium

Future cosmology space missions will concentrate on measuring the polarization of the Cosmic Microwave Background, which potentially carries invaluable information about the earliest phases of the evolution of our universe. Such ambitious projects will ultimately be limited by the sensitivity of the instrument and by the accuracy at which polarized foreground emission from our own Galaxy can be subtracted out. We present the PILOT balloon project which will aim at characterizing one of these foreground sources, the polarization of the dust continuum emission in the diffuse interstellar medium. The PILOT experiment will also constitute a test-bed for using multiplexed bolometer arrays for polarization measurements. We present the results of ground tests obtained just before the first flight of the instrument.Comment: 17 pages, 13 figures. Presented at SPIE, Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy VII. To be published in Proc. SPIE volume 915

Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation

Pediatric gliomas comprise a broad range of brain tumors derived from glial cells. While high-grade gliomas are often resistant to therapy and associated with a poor outcome, children with low-grade gliomas face a better prognosis. However, the treatment of low-grade gliomas is often associated with severe long-term adverse effects. This shows that there is a strong need for improved treatment approaches. Here, we highlight the potential for repurposing disulfiram to treat pediatric gliomas. Disulfiram is a drug used to support the treatment of chronic alcoholism and was found to be effective against diverse cancer types in preclinical studies. Our results show that disulfiram efficiently kills pediatric glioma cell lines as well as patient-derived glioma stem cells. We propose a novel mechanism of action to explain disulfiram’s anti-oncogenic activities by providing evidence that disulfiram induces the degradation of the oncoprotein MLL. Our results further reveal that disulfiram treatment and MLL downregulation induce similar responses at the level of histone modifications and gene expression, further strengthening that MLL is a key target of the drug and explaining its anti-oncogenic properties