High temperature fatigue behaviour in an advanced nickel based superalloy: The effects of oxidation and stress relaxation at notches

The low cycle fatigue performance of the nickel based superalloy RR1000 was investigated under a variety of load waveforms at high temperature, employing a double edge notch geometry under load control. Experiments on a plain cylindrical specimen design under strain control were later performed to simulate the constrained conditions at the root of the notch in order to characterise the interaction between surface constituents and the environment. A significant fatigue debit was demonstrated under both load/strain scenarios when superimposing a dwell period at the minimum point of the cycle. This debit was attributed to a reduction in fatigue crack initiation life resulting from oxidation damage which subsequently cracks under cyclic tension together with a modification to the mean stress through cyclic stabilisation. The same dwell period superimposed at the peak of the cycle was essentially benign for excursions under strain control loading

Structural elucidation of o-linked glycopeptides by high energy collision-induced dissociation

O-linked glycopeptides that bear a GalNAc core with and without the presence of sialic acid have been analyzed by high energy collision-induced dissociation (CID). We show that the CID spectra from the glycosylated precursor ions contain sufficient information to identify the peptide sequence and to determine the glycosylated site(s). Asialo O-linked glycopeptides, previously prepared from a tryptic digest of bovine fetuin were studied. One of the glycopeptides contained only a single Hex (hexose)-HexNAc (N-acetylhexosamine) substitution at Thr262, whereas the other exhibited Hex-HexNAc moieties at both Thr262 and Ser264. In addition, sialo and asialo fetuin glycopeptides from a pronase digest were derivatized with t-butoxycarbonyl-tyrosine, and characterized by high energy CID analysis. The presence of a Galβ(1,3)GalNAc core structure at Ser264 was confirmed by using the substrate specificity of endo-α-N-acetylgalactosaminidase. These studies revealed the presence of a β-galactosidase specific for β(1,4) linkages in the endo-α-N-acetylgalactosaminidase preparation employed. Finally, the relative stability of N-and O-glycosyl bonds to high energy CID is addressed based upon comparison of the behavior of a synthetic N-linked glycopeptide with analogous O-linked structures

E-therapies in England for stress, anxiety or depression: What is being used in the NHS A survey of mental health services

Objective: To document the range of web and smartphone apps used and recommended for stress, anxiety or depression by the National Health Service (NHS) in England. Design: The study was conducted using Freedom of Information (FOI) requests and systematic website searches. Data sources: Data were collected via FOI requests to NHS services between 13 February 2015 and 31 March 2015, and searches conducted on NHS apps library websites between 26 March 2015 and 2 November 2015. Data collection/extraction methods: Data were compiled from responses to: (1) FOI requests sent to all Improving Access to Psychological Therapies (IAPT) services and NHS Mental Health Trusts in England and (2) NHS apps library search results. Results: A total of 61 (54.95%) out of the then 111 IAPT service providers responded, accounting for 191 IAPT services, and all 51 of the then NHS Mental Health Trusts responded. The results were that 13 different web apps and 35 different smartphone apps for depression, anxiety or stress were available through either referral services or the online NHS Apps Libraries. The apps used and recommended vary by area and by point of access (online library/IAPT/trust). Conclusions: Future research is required to establish the evidence base for the apps that are being used in the NHS in England. There is a need for service provision to be based on evidence and established guidelines

Accretion signatures in the X-shooter spectrum of the substellar companion to SR12

About a dozen substellar companions orbiting young stellar objects or pre-main sequence stars at several hundred au have been identified in the last decade. These objects are interesting both due to the uncertainties surrounding their formation, and because their large separation from the host star offers the potential to study the atmospheres of young giant planets and brown dwarfs. Here, we present X-shooter spectroscopy of SR 12 C, a ∼2 Myr young brown dwarf orbiting SR 12 at an orbital separation of 1083 au. We determine the spectral type, gravity, and effective temperature via comparison with models and observational templates of young brown dwarfs. In addition, we detect and characterize accretion using several accretion tracers. We find SR 12 C to be a brown dwarf of spectral type L0 ± 1, log g = 4 ± 0.5, an effective temperature of 2600 ± 100 K. Our spectra provide clear evidence for accretion at a rate of ∼10−10 M⊙ yr−1. This makes SR 12 one of the few sub-stellar companions with a reliable estimate for its accretion rate. A comparison of the ages and accretion rates of sub-stellar companions with young isolated brown dwarfs does not reveal any significant differences. If further accretion rate measurements of a large number of substellar companions can confirm this trend, this would hint towards a similar formation mechanism for substellar companions at large separations and isolated brown dwarfs

Mersenne Primes, Polygonal Anomalies and String Theory Classification

It is pointed out that the Mersenne primes $M_p=(2^p-1)$ and associated perfect numbers ${\cal M}_p=2^{p-1}M_p$ play a significant role in string theory; this observation may suggest a classification of consistent string theories.Comment: 10 pages LaTe

E-Therapies in England for stress, anxiety or depression: How are apps developed? A survey of NHS e-therapy developers

© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. To document the quality of web and smartphone apps used and recommended for stress, anxiety or depression by examining the manner in which they were developed. Design The study was conducted using a survey sent to developers of National Health Service (NHS) e-therapies. Data sources Data were collected via a survey sent out to NHS e-therapy developers during October 2015 and review of development company websites during October 2015. Data collection/extraction methods Data were compiled from responses to the survey and development company websites of the NHS e-therapies developers. Results A total of 36 (76.6%) out of the 48 app developers responded. One app was excluded due to its contact details and developer website being unidentifiable. Data from the missing 10 was determined from the app developer's website. The results were that 12 out of 13 web apps and 20 out of 34 smartphone apps had clinical involvement in their development. Nine out of 13 web apps and nine out of 34 smartphone apps indicated academic involvement in their development. Twelve out of 13 web apps and nine out of 34 smartphone apps indicated published research evidence relating to their app. Ten out of 13 web apps and 10 out of 34 smartphone apps indicated having other evidence relating to their app. Nine out of 13 web apps and 19 out of 34 smartphone apps indicated having a psychological approach or theory behind their app. Conclusions As an increasing number of developers are looking to produce e-therapies for the NHS it is essential they apply clinical and academic best practices to ensure the creation of safe and effective apps

Strong Phase Separation in a Model of Sedimenting Lattices

We study the steady state resulting from instabilities in crystals driven through a dissipative medium, for instance, a colloidal crystal which is steadily sedimenting through a viscous fluid. The problem involves two coupled fields, the density and the tilt; the latter describes the orientation of the mass tensor with respect to the driving field. We map the problem to a 1-d lattice model with two coupled species of spins evolving through conserved dynamics. In the steady state of this model each of the two species shows macroscopic phase separation. This phase separation is robust and survives at all temperatures or noise levels--- hence the term Strong Phase Separation. This sort of phase separation can be understood in terms of barriers to remixing which grow with system size and result in a logarithmically slow approach to the steady state. In a particular symmetric limit, it is shown that the condition of detailed balance holds with a Hamiltonian which has infinite-ranged interactions, even though the initial model has only local dynamics. The long-ranged character of the interactions is responsible for phase separation, and for the fact that it persists at all temperatures. Possible experimental tests of the phenomenon are discussed.Comment: To appear in Phys Rev E (1 January 2000), 16 pages, RevTex, uses epsf, three ps figure

Nodal Quasiparticle Dispersion in Strongly Correlated d-wave Superconductors

We analyze the effects of a momentum-dependent self-energy on the photoemission momentum distribution curve (MDC) lineshape, dispersion and linewidth. We illustrate this general analysis by a detailed examination of nodal quasiparticles in high Tc cuprates. We use variational results for the nodal quasiparticle weight Z (which varies rapidly with hole doping x) and the low energy Fermi velocity $v_F^{low}$ (which is independent of x), to show that the high energy MDC dispersion $v_{high} = v_F^{low}/Z$, so that it is much larger than the bare (band structure) velocity and also increases strongly with underdoping. We also present arguments for why the low energy Fermi velocity and the high energy dispersion are independent of the bare band structure at small x. All of these results are in good agreement with earlier and recent photoemission data [Zhou et al, Nature 423, 398 (2003)].Comment: 4 pages, 3 eps fig

Exact Cover with light

We suggest a new optical solution for solving the YES/NO version of the Exact Cover problem by using the massive parallelism of light. The idea is to build an optical device which can generate all possible solutions of the problem and then to pick the correct one. In our case the device has a graph-like representation and the light is traversing it by following the routes given by the connections between nodes. The nodes are connected by arcs in a special way which lets us to generate all possible covers (exact or not) of the given set. For selecting the correct solution we assign to each item, from the set to be covered, a special integer number. These numbers will actually represent delays induced to light when it passes through arcs. The solution is represented as a subray arriving at a certain moment in the destination node. This will tell us if an exact cover does exist or not.Comment: 20 pages, 4 figures, New Generation Computing, accepted, 200

What do young athletes implicitly understand about psychological skills?

One reason sport psychologists teach psychological skills is to enhance performance in sport; but the value of psychological skills for young athletes is questionable because of the qualitative and quantitative differences between children and adults in their understanding of abstract concepts such as mental skills. To teach these skills effectively to young athletes, sport psychologists need to appreciate what young athletes implicitly understand about such skills because maturational (e.g., cognitive, social) and environmental (e.g., coaches) factors can influence the progressive development of children and youth. In the present qualitative study, we explored young athletes’ (aged 10–15 years) understanding of four basic psychological skills: goal setting, mental imagery, self-talk, and relaxation. Young athletes (n = 118: 75 males and 43 females) completed an open-ended questionnaire to report their understanding of these four basic psychological skills. Compared with the older youth athletes, the younger youth athletes were less able to explain the meaning of each psychological skill. Goal setting and mental imagery were better understood than self-talk and relaxation. Based on these findings, sport psychologists should consider adapting interventions and psychoeducational programs to match young athletes’ age and developmental level