Arabic Musical Instruments: From a MS in the Farmer Collection

Abstract Not Provided

The enigma of facial asymmetry:is there a gender specific pattern of facedness?

Although facial symmetry correlates with facial attractiveness, human faces are often far from symmetrical with one side frequently being larger than the other (Kowner, 1998). Smith (2000) reported that male and female faces were asymmetrical in opposite directions, with males having a larger area on the left side compared to the right side, and females having a larger right side compared to the left side. The present study attempted to replicate and extend this finding. Two databases of facial images from Stirling and St Andrews Universities, consisting of 180 and 122 faces respectively, and a third set of 62 faces collected at Abertay University, were used to examine Smith's findings. Smith's unique method of calculating the size of each hemiface was applied to each set. For the Stirling and St Andrews sets a computer program did this automatically and for the Abertay set it was done manually. No significant overall effect of gender on facial area asymmetry was found. However, the St Andrews sample demonstrated a similar effect to that found by Smith, with females having a significantly larger mean area of right hemiface and males having a larger left hemiface. In addition, for the Abertay faces handedness had a significant effect on facial asymmetry with right-handers having a larger left side of the face. These findings give limited support for Smith's results but also suggest that finding such an asymmetry may depend on some as yet unidentified factors inherent in some methods of image collection

AMPK promotes lysosomal and mitochondrial biogenesis via folliculin:FNIP1

The AMP-activated protein kinase (AMPK) is known to maintain the integrity of cellular mitochondrial networks by (i) promoting fission, (ii) inhibiting fusion, (iii) promoting recycling of damaged components via mitophagy, (iv) enhancing lysosomal biogenesis to support mitophagy, and (v) promoting biogenesis of new mitochondrial components. While the AMPK targets underlying the first three of these effects are known, a recent paper suggests that direct phosphorylation of the folliculin-interacting protein 1 (FNIP1) by AMPK may be involved in the remaining two.</p

Effect of statin and aspirin use on toxicity and pathological complete response rate of neo-adjuvant chemoradiation for rectal cancer

Aim To retrospectively evaluate the potential impact of statin and aspirin use on acute toxicity and pathological complete response (pCR) rate in rectal cancer patients receiving neo-adjuvant long-course radiation therapy (LCRT) with concurrent chemotherapy. Methods A retrospective review was performed of all patients undergoing neo-adjuvant LCRT for rectal adenocarcinoma at the Regional Cancer Treatment Service between 1 September 2007 and 1 June 2011. Data obtained include demographic details; date and radiological TNM stage at diagnosis; medication taken at time of RT; toxicity during LCRT; and surgical histology to determine if a pCR was obtained following LCRT. Results Neo-adjuvant LCRT was administered to 142 patients for rectal cancer during this period; concurrent chemotherapy was omitted in 13 due to significant comorbidities. TNM stage was 2 or 3 radiologically at diagnosis in 127 (89.4%) of patients. At the time of LCRT, 23% were taking a statin and 25% were taking aspirin. Of 135 assessable patients, 34 (13%) achieved a pCR at surgery. On logistic regression, pCR was not significantly associated with the use of chemotherapy, statins, aspirin, other NSAIDs, T-stage or N-stage. There was no significant correlation between statin or aspirin use with bladder or rectal toxicity. Actuarial time to maximum rectal toxicity was not different in statin users or nonusers. Conclusion In contrast to other larger retrospective series, this study did not find improvements in toxicity or pCR rate through statin or aspirin use in rectal cancer patients undergoing LCRT. Their potential benefits in this setting would be best studied prospectively in a large randomized trial

Young People’s Differential Vulnerability to Criminogenic Exposure: Bridging The Gap Between People and Place Oriented Approaches in the Study of Crime Causation

The overall purpose of this study is to contribute to bridging the gap between people and place oriented approaches in the study of crime causation. To achieve this we will explore some core hypotheses derived from Situational Action Theory (SAT) about what makes young people crime prone and places criminogenic, and about the interaction between crime propensity and criminogenic exposure predicting crime events. We will also calculate the expected reduction in aggregate levels of crime that will occur as a result of successful interventions targeting crime propensity and criminogenic exposure. To test the hypotheses we will utilise a unique set of space-time budget, small area community survey, land use and interviewer-led questionnaire data from the prospective longitudinal Peterborough Adolescent and Young Adult Development Study (PADS+) and an Artificial Neural Network approach to modelling. The results show that people’s crime propensity (based on their personal morals and abilities to exercise self-control) has the bulk of predictive power, but also that including criminogenic exposure (being unsupervised with peers and engaged in unstructured activities in residential areas of poor collective efficacy or commercial centres) demonstrates a substantial increase in predictive power (in addition to crime propensity). Moreover, the results show that the probability of crime is strongest when a crime prone person takes part in a criminogenic setting and, crucially, that the higher a person’s crime propensity the more vulnerable he or she is to influences of criminogenic exposure. Finally, the findings suggest that a reduction in people’s crime propensity has a much bigger impact on their crime involvement than a reduction in their exposure to criminogenic settings.This research was supported by grants from the UK Economic & Social Research Council (ESRC grant ES/K010646/1); the European Research Council (grants IDCAB 220/104702003 and Momentum 324247) and Riksbankens Jubileumsfond - the Swedish Foundation for Humanities and Social Sciences

Further experiements on the control of early blight or target spot of potatoes

The effective control of Potato Early Blight or Target Spot by the use of Zineb fungicide (used in the proprietary form Dithane Z.78) has previously been reported in this Journal. It was shown in preliminary spray trials that the foliage blight caused by this disease is very destructive, and by the application of four Dithane sprays yields were increased in the order of 30 per cent., equivalent to approximately four tons per acre. Further experiments have now been conducted and the results indicate that even two applications of Dithane spray may, under conditions of severe blight attack, promote worthwhile higher yields

Plant disease - early blight or target spot of potatoes

Early blight or target spot caused by the fungus Alternaria solani is a widespread disease of potatoes which in Western Australia is most prevalent in crops dug in autumn and early summer. The disease may attack both foliage and tubers, but the tuber rot phase of the disease has hitherto caused most concern to local growers because it causes obvious losses in storage. The less obvious but more serious effects of the foliage blight have generally been overlooked, chiefly because the disease usually develops late in the season when the crops are approaching maturity. However recent spray trials with new fungicides have clearly demonstrated that the destructiveness of the foliage attack has been greatly underestimated, for it may cause considerable reduction in yield

The fibre of a pinch map in a model category

In the category of pointed topological spaces, let F be the homotopy fibre of the pinching map X ∪ CA → X ∪ CA/ X from the mapping cone on a cofibration A → X onto the suspension of A. Gray (Proc Lond Math Soc (3) 26:497–520, 1973) proved that F is weakly homotopy equivalent to the reduced product (X, A)∞. In this paper we prove an analogue of this phenomenon in a model category, under suitable conditions including a cube axiom.Web of Scienc

Validity of a two-item physical activity questionnaire for assessing attainment of physical activity guidelines in youth

Background: As physical activity is important for health and well-being, it is essential to monitor population prevalence of physical activity. Surveillance is dependent on the use of valid and reliable measurement tools. The PACE+ questionnaire is used globally in youth and has acceptable reliability; however it has not been validated in a European sample. The purpose of this study is to validate this instrument in a sample of 10-18 year old Irish youth. Methods: Participants (n=419, 45.7 % male) completed the PACE+ two-item questionnaire and were asked to wear an Actigraph accelerometer for eight consecutive days. Freedson cut-points were used to estimate moderate to vigorous physical activity from accelerometer counts. Analyses compared self-report and accelerometry data in participants with (1) ≥5 and (2) seven valid accelerometer days. Calculations were performed for the whole sample, and were stratified by sex and school level (primary; post-primary). Results: Spearman correlations between self-reported physical activity levels and accelerometry derived minutes of moderate-to-vigorous physical activity per day were small (r=0.27; seven valid days) to moderate (r=0.34; ≥5 valid days). Higher correlations were found in older participants (post-primary r=0.39; primary r=0.24) and females (r=0.39; males r=0.27) using ≥5 valid days. The agreement level was high (68-96 %). The accuracy of classifying those not meeting the guidelines (specificity) was moderate to high (59-100 %). Conclusions: The PACE+ self-report instrument has acceptable validity for assessing non-achievement of the adolescent physical activity recommendations. The validity is higher in females and increases with age. The continued use of the tool is recommended and will allow for comparability between studies, tracking of physical activity over time including trends in youth population prevalence