Deglaciation of Fennoscandia

To provide a new reconstruction of the deglaciation of the Fennoscandian Ice Sheet, in the form of calendar-year time-slices, which are particularly useful for ice sheet modelling, we have compiled and synthesized published geomorphological data for eskers, ice-marginal formations, lineations, marginal meltwater channels, striae, ice-dammed lakes, and geochronological data from radiocarbon, varve, optically-stimulated luminescence, and cosmogenic nuclide dating. This 25 is summarized as a deglaciation map of the Fennoscandian Ice Sheet with isochrons marking every 1000 years between 22 and 13 cal kyr BP and every hundred years between 11.6 and final ice decay after 9.7 cal kyr BP. Deglaciation patterns vary across the Fennoscandian Ice Sheet domain, reflecting differences in climatic and geomorphic settings as well as ice sheet basal thermal conditions and terrestrial versus marine margins. For example, the ice sheet margin in the high-precipitation coastal setting of the western sector responded sensitively to climatic variations leaving a detailed record of prominent moraines and ice-marginal deposits in many fjords and coastal valleys. Retreat rates across the southern sector differed between slow retreat of the terrestrial margin in western and southern Sweden and rapid retreat of the calving ice margin in the Baltic Basin. Our reconstruction is consistent with much of the published research. However, the synthesis of a large amount of existing and new data support refined reconstructions in some areas. For example, we locate the LGM extent of the ice sheet in northwestern Russia further east than previously suggested and conclude that it occurred at a later time than the rest of the ice sheet, at around 17-15 cal kyr BP, and propose a slightly different chronology of moraine formation over southern Sweden based on improved correlations of moraine segments using new LiDAR data and tying the timing of moraine formation to Greenland ice core cold stages. Retreat rates vary by as much as an order of magnitude in different sectors of the ice sheet, with the lowest rates on the high-elevation and maritime Norwegian margin. Retreat rates compared to the climatic information provided by the Greenland ice core record show a general correspondence between retreat rate and climatic forcing, although a close match between retreat rate and climate is unlikely because of other controls, such as topography and marine versus terrestrial margins. Overall, the time slice reconstructions of Fennoscandian Ice Sheet deglaciation from 22 to 9.7 cal kyr BP provide an important dataset for understanding the contexts that underpin spatial and temporal patterns in retreat of the Fennoscandian Ice Sheet, and are an important resource for testing and refining ice sheet models

Ice surface changes during recent glacial cycles along the Jutulstraumen and Penck Trough ice streams in western Dronning Maud Land, East Antarctica

Reconstructing past ice-sheet surface changes is key to testing and improving ice-sheet models. Data constraining the past behaviour of the East Antarctic Ice Sheet are sparse, limiting our understanding of its response to past, present and future climate change. Here, we report the first cosmogenic multi-nuclide (10Be, 26Al, 36Cl) data from bedrock and erratics on nunataks along the Jutulstraumen and Penck Trough ice streams in western Dronning Maud Land, East Antarctica. Spanning elevations between 741 and 2394 m above sea level, the samples have apparent exposure ages between 2 ka and 5 Ma. The highest-elevation bedrock sample indicates (near-) continuous minimum exposure since the Pliocene, with a low apparent erosion rate of 0.15 ± 0.03 m Ma−1, which is similar to results from eastern Dronning Maud Land. In contrast to studies in eastern Dronning Maud Land, however, our data show clear indications of a thicker-than-present ice sheet within the last glacial cycle, with a thinning of ∼35–120 m during the Holocene (∼2–11 ka). Difficulties in separating suitable amounts of quartz from the often quartz-poor rock-types in the area, and cosmogenic nuclides inherited from exposure prior to the last deglaciation, prevented robust thinning estimates from elevational profiles. Nevertheless, the results clearly demonstrate ice-surface fluctuations of several hundred meters between the current grounding line and the edge of the polar plateau for the last glacial cycle, a constraint that should be considered in future ice-sheet model simulations

Changes in vertical ice extent along the East Antarctic Ice Sheet margin in western Dronning Maud Land – initial field and modelling results of the MAGIC-DML collaboration

Constraining numerical ice sheet models by comparison with observational data is crucial to address the interactions between cryosphere and climate at a wide range of scales. Such models are tested and refined by comparing model predictions of past ice geometries with field-based reconstructions from geological, geomorphological, and ice core data. However, for the East Antarctic Ice sheet, there is a critical gap in the empirical data necessary to reconstruct changes in ice sheet geometry in the Dronning Maud Land (DML) region. In addition, there is poor control on the regional climate history of the ice sheet margin, because ice-core locations, where detailed reconstructions of climate history exist, are located on high inland domes. This leaves numerical models ofregional glaciation history in this near-coastal area largely unconstrained. MAGIC-DML is an ongoing Swedish-US-Norwegian-German-UK collaboration with a focus on improvingice sheet models of the western DML margin by combining advances in modeling with filling critical data gaps regarding the timing and pattern of ice-surface changes. A combination of geomorphological mapping using remote sensing data, field observations, cosmogenic nuclide surface exposure dating, and numerical ice sheetmodeling are being used in an iterative manner to produce a comprehensive reconstruction of the glacial historyof western DML. Here, we present an overview of the project, field evidence for formerly higher ice surfaces and in-situ cosmogenic nuclide measurements from the 2016/17 expedition. Preliminary field evidence indicate that interior sectors of DML have experienced a general decrease in ice sheet thickness since the late Miocene, with potential episodes of increasing thickness in the late Pleistocene (700-300 ka, 250-75 ka). To aid in interpreting these field data, new high-resolution ice sheet model reconstructions, constraining ice sheet configurations during key episodes, are presented

Mid-Pleistocene ice sheet fluctuations from cosmogenic nuclide field constraints in western Dronning Maud Land, Antarctica

The East Antarctic Ice Sheet (EAIS) is generally assumed to have been relatively insensitive to Quaternary climat echange. However, recent studies have shown potential instabilities in coastal, marine sectors of the EAIS. In addition, long-term climate reconstructions and modelling experiments indicate the potential for significant changes in ice volume and ice sheet configuration since the Pliocene. Hence, more empirical evidence for ice surface and ice volume changes is required to discriminate between contrasting inferences. MAGIC-DML is an ongoing Swedish-US-Norwegian-German-UK collaboration focused on improving ice sheetm odels by filling critical data gaps that exist in our knowledge of the timing and pattern of ice surface changes along the western Dronning Maud Land (DML) margin and combining this with advances in numerical techniques. As part of the project, field studies in the 2016/17 and 2017/18 austral summers targeted selected sites spanning accessible altitudes in the Heimefrontfjella, Vestfjella, Ahlmannryggen, Borgmassivet, and Kirwanveggen nunatakranges for in situcosmogenic nuclide sampling. Comparing concentrations of nuclides with widely differing half-lives in bedrock and erratics from a range of altitudes above modern ice surfaces can provide information on ice sheet fluctuations and complex burial and exposure histories, and thus, past configurations of non-erosive ice. Quartz-bearing rock types were sampled and analyzed for 10Be (t1/21.4 My),14C (t1/25.7 ky),26Al (t1/2705ky), and 21Ne (stable), and mafic lithologies for36Cl (t1/2301 ky). Results thus far for 3210Be and 26Al isotope pairs complemented with seven21Ne measurements have yielded some consistent patterns of paleoglaciation for the western DML margin. Eight out of fourteen bedrock samples from high-elevation (1700-2238 m a.s.l.) ridges and summits return some of the oldest exposure ages in Antarctica and have consistent 10Be,26Al, and 21Ne minimum apparent exposure ages of 1.8-4.1 Ma. Initial results therefore indicate that parts of the ice sheet marginal to the Antarctic plateau, along the Heimefrontfjella range, generally have experienced a decrease in ice thickness since the late Miocene. Another six bedrock samples (1556-1732 ma.s.l.) fall in the 300-700 ka range, and they all show significant burial. At face value, perhaps this indicates aregional ice sheet surface above 1700 m a.s.l. for much of the Plio-early Pleistocene. All other samples analyzedto date are erratics from lower elevation and more coastal sites (10 from nunataks at 553-1400 m a.s.l., and 6 froma surface moraine at 1385 m a.s.l.), exhibiting ages between 59 and 275 ka, save for two (4 and 6 ka). Whereas almost all of the nunatak erratics (including the young ones) show significant burial durations, five of the six surface moraine samples do not. These 2016/17 field samples are not yet leading to conclusive age constraints but already start to paint a picture of the western DML margin being relatively stable although there was possibly one or more episodes of relatively limited ice thickening during the last 700 ka

Environmental and Molecular Mutagenesis Meeting Report Assessing Human Germ-Cell Mutagenesis in the Post-Genome Era: A Celebration of the Legacy of William Lawson (Bill) Russell

ABSTRACT Although numerous germ-cell mutagens have been identified in animal model systems, to date, no human germ-cell mutagens have been confirmed. Because the genomic integrity of our germ cells is essential for the continuation of the human species, a resolution of this enduring conundrum is needed. To facilitate such a resolution, we organized a workshop at The Jackson Laboratory in Bar Harbor, Maine on September [28][29][30] 2004. This interactive workshop brought together scientists from a wide range of disciplines to assess the applicability of emerging molecular methods for genomic analysis to the field of human germ-cell mutagenesis. Participants recommended that focused, coordinated human germ-cell mutation studies be conducted in relation to important societal exposures. Because cancer survivors represent a unique cohort with well-defined exposures, there was a consensus that studies should be designed to assess the mutational impact on children born to parents who had received certain types of mutagenic cancer chemotherapy prior to conceiving their children. Within this high-risk cohort, parents and children could be evaluated for inherited changes in (a) gene sequences and chromosomal structure, (b) repeat sequences and minisatellite regions, and (c) global gene expression and chromatin. Participants also recommended studies to examine trans-generational effects in humans involving mechanisms such as changes in imprinting and methylation patterns, expansion of nucleotide repeats, or induction of mitochondrial DNA mutations. Workshop participants advocated establishment of a bio-bank of human tissue samples that could be used to conduct a multiple-endpoint, comprehensive, and collaborative effort to detect exposure-induced heritable alterations in the human genome. Appropriate animal models of human germ-cell mutagenesis should be used in parallel with human studies to provide insights into the mechanisms of mammalian germ-cell mutagenesis. Finally, participants recommended that 4 scientific specialty groups be convened to address specific questions regarding the potential germ-cell mutagenicity of environmental, occupational, and lifestyle exposures. Strong support from relevant funding agencies and engagement of scientists outside the fields of genomics and germ-cell mutagenesis will be required to launch a full-scale assault on some of the most pressing and enduring questions in environmental mutagenesis: Do human germ-cell mutagens exist, what risk do they pose to future generations, and are some parents at higher risk than others for acquiring and transmitting germ-cell mutations?

Compliance with diabetes guidelines at a regional hospital in KwaZulu-Natal, South Africa

Background: Diabetes is a major problem in South Africa and throughout the world. Themanagement of type 2 diabetes aims at maintaining normoglycaemia and preventing thedevelopment of complications arising from diabetes. The Society for Endocrine Metabolismand Diabetes of South Africa (SEMDSA) guidelines are based on a number of internationaltrials which showed that strict control of blood sugar leads to a reduction in the developmentof diabetic complications. However, many studies have shown poor adherence to nationalguidelines by doctors caring for diabetes patients. Objectives: The aim of this study was to assess doctors’ compliance with the SEMDSA diabetesguidelines at a regional hospital in KwaZulu-Natal.Method: Seven hundred and fifty diabetic patient records were selected by systematicsampling of cases from the diabetic clinic and reviewed against SEMDSA guidelines. Results: Eighty three per cent of the patients had high values of glycated haemoglobin (HbA1c).Lipid examination was rarely performed, and comprehensive foot examination was carriedout in only 6% of patients. Although blood pressure and weight were regularly checked,these examinations were performed by the nursing staff, and medical staff generally did notrespond to abnormal results. Conclusion: This study demonstrates poor compliance with current diabetic guidelines. Thereis an urgent need to review how guidelines are disseminated and implemented in South Africanpublic sector hospitals if evidence-based guidelines are to have any impact on patient care