Frequency and outcome of acute neurologic complications after congenital heart disease surgery

Objectives: To determine the frequency and immediate outcome of acute neurologic complications (ANCs) in children undergoing congenital heart surgery (CHS).Materials and Methods: Inthis retrospective study, all patients undergoing CHS at our hospital from January 2007 to June 2016 were included. Patients were followed up for the development of seizures, altered level of consciousness (ALOC), abnormal movements, and stroke. Results are presented as mean with standard deviation and frequency with percentages.Results: Of 2000 patients who underwent CHS at our center during the study, 35 patients (1.75%) developed ANC. Seizures occurred in 28 (80%), ALOC in 5 (14%), clinical stroke in 2, brain death in 6 patients. Antiepileptic drugs (AEDs) were started in 32 patients, of which 13 patients required more than one AED. Mean length of stay was 10 ± 7.36 days. Of 35 patients who developed ANC, 7 expired during the study.Conclusion: Neurological complications are scarce but significant morbidity after CHS at our center

A Management of forgotten double J Ureteric stent in a young male: A Case Report

Urologic devices called Double-J stents (DJSs) are frequently used to treat urinary tract blockage. Advancement in endourology in last few decades has led to an increase in use of ureteric stents and so its related complications. Herein, we report a case of a 17 years old male patient of poor socioeconomic background from a remote village of Afghanistan, presented to our out-patient department with abdominal pain at the right flank. He had history of double J stent placement during right open pyelolithotomy 6 year before. However, no further details were available

Efficacy of Tamsulosin Alone and Combination with Tolterodine in Managing Intramural Ureteric Stone

Objective: To compare the efficacy of Tamsulosin alone and combination with  in  managing intramural ureteric stone in order to obviate the need for surgical treatment and related complications Methodology: A total of 104 patients with distal ureteral stones were included in the study (90 men and 14 women) age ranging from 19 to 59 years. Those with stones less than 10 mm and allowing urinary flow were included in the study. Asymptomatic or incidentally found Intramural Ureteric Stone, Ureteric stone along with kidney stone, Presence of urinary sepsis, Chronic kidney disease stage 4 or stage 5, Pregnancy, Patients currently taking an α-blocker/Antimuscrinic agents, Gross hydronephrosis, Diabetes were excluded from the study. After randomization, divided 2 groups and patients were given respective drugs. Group 1 patients received Tamsulosin 0.4 mg/day, group 2 patients received Tamsulosin 0.4 mg/day plus  2 mg (twice a day). Results: The mean days of stone expulsion was 20.05± 6.11 and 10.41±4.63 days in group 1 and 2, respectively which was significantly shorter in group 2 (p-value, <0.001). Overall in 43 (82.6%) patients in group 2 and 34 (65.3%) cases in group 2, stone was expulsed before 28 days. The expulsion of intramural ureteric stones were more observed in patients treated with combination therapy (group 2) than tamulosin alone therapy. The mean duration of expulsion of stones was also found significantly shorter the combination therapy group. Conclusion: In the present study, the expulsion of intramural ureteric stones were more observed in patients treated with combination therapy (group 2) than tamulosin alone therapy. It is concluded that Tamsulosin combined with  has a better effect in terms of intramural ureteric stone expulsion

Detection of regional DNA methylation using DNA-graphene affinity interactions

We report a new multiplexed strategy for the electrochemical detection of regional DNA methylation across multiple regions. Using the sequence dependent affinity of bisulfite treated DNA towards gold surfaces, the method integrates the high sensitivity of a micro-fabricated multiplex device comprising a microarray of gold electrodes, with the powerful multiplexing capability of multiplex-PCR. The synergy of this combination enables the monitoring of the methylation changes across several genomic regions simultaneously from as low as 500 pg μl(-1) of DNA with no sequencing requirement

Marriage and sexual and reproductive health of Rohingya adolescents and youth in Bangladesh: A qualitative study

This qualitative study focuses specifically on displaced Rohingya adolescents and youth (ages 14–24) and explores how the crisis has impacted their sexual and reproductive health (SRH), marriage practices, safety and security, and related attitudes and aspirations. This research aims to identify approaches to improve adolescents’ knowledge of SRH issues and their access to and uptake of services, and to identify gaps in programming knowledge and practice. Findings from this formative research and recommended actions will help the Government of Bangladesh, donors, and other relevant stakeholders to mobilize resources and deliver SRH services in a more organized and efficient way and thus help to ensure the well-being of the Rohingya adolescents and youth

The fingerprints of climate warming on cereal crops phenology and adaptation options

Growth and development of cereal crops are linked to weather, day length and growing degree-days (GDDs) which make them responsive to the specific environments in specific seasons. Global temperature is rising due to human activities such as burning of fossil fuels and clearance of woodlands for building construction. The rise in temperature disrupts crop growth and development. Disturbance mainly causes a shift in phenological development of crops and affects their economic yield. Scientists and farmers adapt to these phenological shifts, in part, by changing sowing time and cultivar shifts which may increase or decrease crop growth duration. Nonetheless, climate warming is a global phenomenon and cannot be avoided. In this scenario, food security can be ensured by improving cereal production through agronomic management, breeding of climate-adapted genotypes and increasing genetic biodiversity. In this review, climate warming, its impact and consequences are discussed with reference to their influences on phenological shifts. Furthermore, how different cereal crops adapt to climate warming by regulating their phenological development is elaborated. Based on the above mentioned discussion, different management strategies to cope with climate warming are suggested

Assessment of economic opportunities for young Rohingyas in Bangladesh

Bangladesh has been hosting nearly a million Rohingyas for the past five years. Since the 1980s, to escape widespread persecution and conflict, Rohingyas have been crossing the border from Myanmar into Bangladesh. Rohingyas are not entitled to, or integrated into, any long-term development agendas of the Bangladesh government. They do not have freedom of movement and permission to work, but they are engaged in some informal income-generating activities in Cox’s Bazar. This study was intended to assess the livelihood and work opportunities, challenges, aspirations, needs, and preferences of young Rohingya populations living in the camps in the Cox’s Bazar district of Bangladesh. This is a needs assessment study, and hence there was no intervention. The study consisted of an assessment of economic opportunities of young Rohingyas living in the camps, and a review of global refugee integration programs, followed by policy advocacy. This report presents the findings from our primary research on economic opportunities for Rohingyas

Continuous-time quantum walks for MAX-CUT are hot

By exploiting the link between time-independent Hamiltonians and thermalisation, heuristic predictions on the performance of continuous-time quantum walks for MAX-CUT are made. The resulting predictions depend on the number of triangles in the underlying MAX-CUT graph. We extend these results to the time-dependent setting with multi-stage quantum walks and Floquet systems. The approach followed here provides a novel way of understanding the role of unitary dynamics in tackling combinatorial optimisation problems with continuous-time quantum algorithms.Comment: 25 pages, 29 figure

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Funding: F Carvalho and E Fernandes acknowledge support from Fundação para a Ciência e a Tecnologia, I.P. (FCT), in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy i4HB; FCT/MCTES through the project UIDB/50006/2020. J Conde acknowledges the European Research Council Starting Grant (ERC-StG-2019-848325). V M Costa acknowledges the grant SFRH/BHD/110001/2015, received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006.proofepub_ahead_of_prin