Characterization of p-type silicon semiconductor detectors for use in in vivo dosimetry

The response of a p-type diode detector for use in patient dose monitoring in photon and electron fields was evaluated for a number of commonly-encountered clinical parameters. Effects of energy, field size, source-to-surface distance, presence of beam modifiers, beam orientation, and temperature were investigated. Shielding effects and batch variations were also examined. In most cases, diode performance was in good agreement with manufacturer\u27s specifications and/or the results of others using similar detectors. Variations in excess of +/-12 % were observed in high-energy wedged fields over the source-to-surface distances investigated. Reductions in local dose directly behind the diode due to electron shielding ranged from 8 to 12%. Entrance and exit dose measurements were made on patients undergoing treatment for lung or prostate carcinoma. Differences in measured and calculated exit doses could be improved by the inclusion of tissue heterogeneity correction factors in the treatment planning algorithm

Performance Evaluation of Modified Bitumen with Replaced Percentage of Waste Cooking Oil & Tire Rubber with Bagasse Ash as Modifier

Flexible pavements are the major type of pavement use in recent days. Bitumen is the main constituent’s part of flexible pavement. Bitumen is the by-produce of petroleum. The depleting reserve of petroleum led researcher to look for alternative binder. This research work explicitly aim at replacing certain percentage of bitumen with Tire Rubber powder (TR), Waste Cooking Oil (WCO) in the presence of Bagasse Ash (BA) as a modifier. Physical test were performed to determine optimum percentages of TR, WCO and BA that can be used as a percentage replacement in bitumen. Result shows that up to 20 % of bitumen can be successfully replaced without affecting performance of bitumen. Performance Tests such as Dynamic Shear Rheometer, Rotatory thin film oven, Pressure aging Vessel and Bending Beam Rheometer were performed on modified samples for its physical and rheological properties. Modified bitumen showed good resistance against rutting, skidding and low temperature cracking. The research work directly contribute in developments of alternative binder for flexible pavement which is a leading research trend these days and environmental friendly initiative

Developmental dysplasia of the hip

Developmental dysplasia of the hip (DDH) is a spectrum of anatomical abnormalities of the hip joint in which the femoral head has an abnormal relationship with the acetabulum. Most studies report an incidence of 1 to 34 cases per 1,000 live births and differences could be due to different diagnostic methods and timing of evaluation. Risk factors include first born status, female sex, positive family history, breech presentation and oligohydramnios. Clinical presentations of DDH depend on the age of the child. Newborns present with hip instability, infants have limited hip abduction on examination, and older children and adolescents present with limping, joint pain, and/or osteoarthritis. Repeated, careful examination of all infants from birth and throughout the first year of life until the child begins walking is important to prevent late cases. Provocative testing includes the Barlow and Ortolani maneuvers. Other signs, such as shorting of the femur with hips and knees flexed (Galeazzi sign), asymmetry of the thigh or gluteal folds, and discrepancy of leg lengths are potential clues. Treatment depends on age at presentation and outcomes are much better when the child is treated early, particularly during the first six months of life

Foreign Bodies in Ear, Nose and Throat - A Clinical Audit

To study the pattern of foreignbodies of ear, nose and throat.Method: This prospective study was conducted on85 patients who presented with complaint of foreignbody insertion / impaction.Results: These cases comprised of 46 (54%) males &39 (46%) females having male: female ratio= 1.17: 1.Out of all patients 37 (43.52%) presented with earforeign bodies, 25 patients (29.4%) presented withnasal cavity foreign bodies, 23 patients (27.05%)presented with throat (oropharyngeal /hypopharyngeal) foreign bodies. General anesthesiawas required in 16 cases (18.8%).Most of foreignbodies were removed by house officers undersupervision by Consultants.Conclusion: Foreign bodies remain a majorconcern in ENT practice .Majority of children werechildre

Continuous user authentication featuring keystroke dynamics based on robust recurrent confidence model and ensemble learning approach

User authentication is considered to be an important aspect of any cybersecurity program. However, one-time validation of user’s identity is not strong to provide resilient security throughout the user session. In this aspect, continuous monitoring of session is necessary to ensure that only legitimate user is accessing the system resources for entire session. In this paper, a true continuous user authentication system featuring keystroke dynamics behavioural biometric modality has been proposed and implemented. A novel method of authenticating the user on each action has been presented which decides the legitimacy of current user based on the confidence in the genuineness of each action. The 2-phase methodology, consisting of ensemble learning and robust recurrent confidence model(R-RCM), has been designed which employs a novel perception of two thresholds i.e., alert and final threshold. Proposed methodology classifies each action based on the probability score of ensemble classifier which is afterwards used along with hyperparameters of R-RCM to compute the current confidence in the genuineness of user. System decides if user can continue using the system or not based on new confidence value and final threshold. However, it tends to lock out imposter user more quickly if it reaches the alert threshold. Moreover, system has been validated with two different experimental settings and results are reported in terms of mean average number of genuine actions (ANGA) and average number of imposter actions(ANIA), whereby achieving the lowest mean ANIA with experimental setting II

Investigation of Alumina-Doped Prunus domestica Gum Grafted Polyaniline Epoxy Resin for Corrosion Protection Coatings for Mild Steel and Stainless Steel

Eco-friendly inhibitors have attracted considerable interest due to the increasing environmental issues caused by the extensive use of hazardous corrosion inhibitors. In this paper, environmentally friendly PDG-g-PANI/Al$_2$O$_3$ composites were prepared by a low-cost inverse emulsion polymerization for corrosion inhibition of mild steel (MS) and stainless steel (SS). The PDG-g-PANI/Al$_2$O$_3$ composites were characterized by different techniques such as X-ray diffraction (XRD), UV/Vis, and FTIR spectroscopy. XRD measurements show that the PDG-g-PANI/Al$_2$O$_3$ composite is mostly amorphous and scanning electron micrographs (SEM) reveal a uniform distribution of Al$_2$O$_3$ on the surface of the PDG-g-PANI matrix. The composite was applied as a corrosion inhibitor on mild steel (MS) and stainless steel (SS), and its efficiency was investigated by potentiodynamic polarization measurement in a 3.5% NaCl and 1 M H$_2$SO$_4$ solution. Corrosion kinetic parameters obtained from Tafel evaluation show that the PDG-g-PANI/Al$_2$O$_3$ composites protect the surface of MS and SS with inhibition efficiencies of 92.3% and 51.9% in 3.5% NaCl solution, which is notably higher than those obtained with untreated epoxy resin (89.3% and 99.5%). In particular, the mixture of epoxy/PDG-g-PANI/Al$_2$O$_3$ shows the best performance with an inhibition efficiency up to 99.9% on MS and SS. An equivalent good inhibition efficiency was obtained for the composite for 1M H$_2$SO$_4$. Analysis of activation energy, formation enthalpy, and entropy values suggest that the epoxy/PDG-g-PANI/Al$_2$O$_3$ coating is thermodynamically favorable for corrosion protection of MS and exhibits long-lasting stability

Combined experimental and theoretical study of poly(aniline-co-pyrrole) oligomer

Quantum mechanical calculations are performed to establish the structure of an oligomer of aniline and pyrrole [Poly(Ani-co-Py)], through comparison of experimental and theoretically calculated properties, including conductivity. The copolymer was synthesized through chemical oxidative polymerization and then confirmed from the experimental IR, UV-vis, mass spectra, elemental, XRD, TGA, and SEM analysis. Quantum mechanical calculations are performed at Density Functional Theory (DFT) and Time dependent DFT (TD-DFT) methods for the electronic and spectroscopic properties of the oligomer. A very nice correlation is found between the theory and experiment which consequences the structure of Poly(Ani-co-Py). Poly(Ani-co-Py) is not explored like other conducting polymers; however, by tuning this molecular structure, the electro-active nature of this material can be enhanced adequately

Development and characterization of a murine hepatoma model expressing hepatitis Cvirus (HCV) non-structural antigens for evaluating HCV vaccines

Hepatitis C (HCV) is a highly prevalent blood-borne virus with infection of 2-3% of world population and high rate of chronicity (\u3e70%) leading to chronic hepatitis, which often progress to cirrhosis and hepatocellular carcinoma. HCV- specific immune responses consisting of CD4 and CD8 T cells and virus neutralizing antibodies have been shown to eliminate HCV infections in humans and chimpanzees. Therefore, vaccines that can induce potent and durable anti-HCV T and B cell responses may have the potential to clear chronic HCV infections. A number of HCV vaccines have been tested clinically with limited success. One of the major limitations in developing effective HCV therapies is the lack of effective and reliable animal models due to the narrow host range of the HCV virus. The study described herein reports the generation of a murine hepatoma cell line expressing HCV non-structural proteins and its use in a metastatic tumor setting to test anti-tumor efficacy of bacterial and viral vector vaccines expressing the HCV non-structural genes. HCV-recombinant hepatoma cells formed large solid-mass tumors when implanted into syngeneic mice, allowing the testing of HCV vaccines for immunogenicity and anti-tumor efficacy. Using this model, we tested the therapeutic potential of recombinant anti-HCV-specific vaccines based on two fundamentally different attenuated pathogen vaccine systems - attenuated Salmonella and recombinant adenoviral vector based vaccine. Attenuated Salmonella secreting HCV antigens limited growth of the HCV-recombinant tumors when used in a therapeutic vaccination setting. The inhibition of tumor growth by Salmonella vector-based vaccines was significantly reduced in mice co-injected with an anti-CD8 antibody, suggesting a role by CD8+ cells in the vaccine efficacy. The model was also used to compare replication deficient and replication-competent but non-infectious adenoviral vectors expressing non-structural HCV antigens. Results showed overall greater survival and reduced weight loss with the replication-competent vector compared to the non-replicating vector. Our results demonstrate the novel recombinant murine hepatoma model expressing HCV non-structural antigens as a useful model for evaluating therapeutic vaccines against HCV. Vaccines that are capable of inducing potent anti-HCV immune responses that are capable of controlling aggressive and metastatic tumor growth in this model would likely have the potential to control chronic viral infections such as HCV. This novel approach is particularly interesting for the development of therapeutic vaccines

Cost Effective Chemical Oxidative Synthesis of Soluble and Electroactive Polyaniline Salt and Its Application as Anticorrosive Agent for Steel

The cost effective synthesis of electroactive polyaniline (PANI) while retaining its desirable properties is one of the most debatable and challenging tasks for researchers in the field. Herein, we report a cost effective inverse emulsion polymerization pathway for the synthesis of soluble and processable PANI salt by using diesel as a novel dispersion medium. Different reaction parameters and their effects on the properties and yield of polyaniline were optimized. The polymer exhibited a highly porous morphology and was found to be stable up to 417 °C. The PANI salt showed good solubility in common solvents, such as chloroform, N-Methyl-2-pyrrolidone (NMP), dimethyl sulphoxide (DMSO) and in a 1:3 mixtures by volume of 2-propanol and toluene. The coating of the synthesized PANI salt on stainless steel has shown good corrosion resistant behavior in marine water by reducing the corrosion rate to 67.9% as compared to uncoated stainless steel

Evaluation of recombinant adenovirus vectors and adjuvanted protein as a heterologous prime-boost strategy using HER2 as a model antigen.

Induction of strong antigen-specific cell-mediated and humoral responses are critical to developing a successful therapeutic vaccine. Herein, using HER2 as a model antigen, we aim to evaluate a therapeutic vaccine protocol that elicits anti-tumor antibody and cytotoxic T cells to HER2/neu antigen. Replication-competent (ΔPS AdV) and non-replicating recombinant adenoviral vectors (AdV) expressing a rat HER2/neu (ErbB2) oncogene, were generated and compared for four different doses and over four time points for their ability to induce antigen-specific T and B cell responses in mice. Although ΔPS AdV:Her2 vector was shown to induce more durable antigen-specific CD8⁺ T cell responses, overall, the AdV:Her2 vector induced broader T and B cell responses. Hence the AdV:Her2 vector was used to evaluate a heterologous prime-boost vaccination regimen using rat HER2 protein encapsulated in archaeosomes composed of a semi-synthetic glycolipid (sulfated S-lactosylarchaeol, SLA; and lactosylarchaeol, LA) (SLA/LA:HER2enc) or admixed with archaeosomes composed of SLA alone (SLA:HER2adm). We first tested AdV:Her2 using a prime-boost approach with SLA/LA:HER2enc, and thereafter evaluated a sub-optimal AdV:Her2 dose in a heterologous prime-boost approach with SLA:HER2adm. A single administration of AdV:Her2 alone induced strong cell-mediated immune responses, whereas SLA/LA:HER2enc alone induced strong antigen-specific IgG titers. In mice primed with a suboptimal dose of AdV:Her2, strong CD8⁺ T-cell responses were observed after a single dose which were not further augmented by protein boost. AdV:Her2 induced CD4⁺ specific T-cell responses were augmented by SLA:HER2adm. Homologous vaccination using SLA:HER2adm induced strong antigen-specific antibody responses. However, the overall magnitude of the responses was similar with three doses of SLA:HER2adm or Ad:HER2 prime followed by two doses of SLA:HER2adm. We demonstrate that AdV:Her2 is capable of inducing strong antigen-specific CD8⁺ T cell responses, even at a low dose, and that these responses can be broadened to include antigen-specific antibody responses by boosting with SLA adjuvanted proteins without compromising CD8 T cell responses elicited by AdV priming