Temperature anomalies in transition-metal-oxides and their correlations with photocatalytic activity: structural, dielectric and electrical characterisation of titania systems

Annealing titania in vacuum while an external electrical field was applied resulted in the observation of structural, morphological and electrical anomalies. However, treating titania in vacuum leads to a redistribution of lattice defects. The diffusion of these lattice defects forms charge carrier trapping sites and permanent dipoles. The alignment of these dipoles leads to the formation of anisotropic conductive channels. Furthermore, the redistribution of lattice defects results in a new crystalline phase

Modellierung und Entwicklung eines Abscheiders zur Entfernung nichtmetallischer Einschlüsse aus Stahlschmelzen

Gegenstand der Arbeit ist die Entwicklung und Modellierung eines keramischen Filters zur Abscheidung von nichtmetallischen Teilchen aus Stahlschmelzen. Ausgehend von einem Konzept eines Umlenkabscheiders wurde dieser mit Hilfe von Experimenten und numerischen Berechnungen auf seine Wirkungsweise und Einsatzfähigkeit für größere Stahlmengen untersucht. Wassermodellversuche dienten zur Erfassung des Geschwindigkeitsfeldes und der Teilchenbewegungen. Durch Vergleich mit numerischen Berechnungen und die Variation von Parametern wurde die Abscheidewirkung des Filters untersucht. In Technikumsversuchen mit Flüssigstahl erfolgte die Verifizierung der Modellvorstellung aus den numerischen Berechnungen und Wassermodellexperimenten. Eine Abscheidung konnte qualitativ nachgewiesen werden. Die gewonnenen Ergebnisse führten zur Entwicklung und Patentierung eines neuen Typs des Einschlussabscheiders. Der neu entwickelte Spiralabscheider weist zahlreiche technologische Vorteile gegenüber dem Umlenkabscheider auf

Charge transfer characteristics of F6TCNNQ–gold interface

The metal–organic interface between polycrystalline gold and hexafluorotetracyanonaphthoquinodimethane (F6TCNNQ) was investigated by photoelectron spectroscopy with the focus on the charge transfer characteristics from the metal to the molecule. The valence levels, as well as the core levels of the heterojunction, indicate a full electron transfer and a change in the chemical environment. The changes are observed in the first F6TCNNQ layers, whereas for further film growth, only neutral F6TCNNQ molecules could be detected. New occupied states below the Fermi level were observed in the valence levels, indicating a lowest unoccupied molecular orbital (LUMO) occupation due to the charge transfer. A fitting of the spectra reveals the presence of a neutral and a charged F6TCNNQ molecules, but no further species were present

Umsetzung und Analyse einer automatisierten Verkehrsnetzabbildung und Verkehrserzeugung im Plangebiet Vogtland

The aim of this work was to write a java program that can read the data of OpenStreetMap and automatically finds the information to create the traffic network out of those data. As well, the program should be able to read other information from the data like attractions for shopping, working, leisure time acitivities and some more. With the given data, the program will calculate how much inhabitants are statistically living in every residential building. The information that were read from the data, should be pointed to the closest traffic nodes. To do that, we tested several algorithms for example to find the shortest routes in the traffic network. In the end, we took the algorithm of Floyd and Warshall to find the shortest routes. With the given data, the traffic should be calculated with different methodes. After all the calculations, the traffic network and the traffic on the traffic network was visualized. The program was written so, that you can cut out an area of the OpenStreetMap data and the program will then do all the steps to calculate everything

Residual stresses in thermite welded rails: significance of additional forging

The aluminothermic welding (ATW) process is the most commonly used welding process for welding rails (track) in the field. The large amount of weld metal added in the ATW process may result in a wide uneven surface zone on the rail head, which may, in rare cases, lead to irregularities in wear and plastic deformation due to high dynamic wheel-rail forces as wheels pass. The present paper studies the introduction of additional forging to the ATW process, intended to reduce the width of the zone affected by the heat input, while not creating a more detrimental residual stress field. Simulations using a novel thermo-mechanical FE model of the ATW process show that addition of a forging pressure leads to a somewhat smaller width of the zone affected by heat. This is also found in a metallurgical examination, showing that this zone (weld metal and heat-affected zone) is fully pearlitic. Only marginal differences are found in the residual stress field when additional forging is applied. In both cases, large tensile residual stresses are found in the rail web at the weld. Additional forging may increase the risk of hot cracking due to an increase in plastic strains within the welded area

NaOH protective layer for a stable sodium metal anode in liquid electrolytes

Sodium is known as a soft metal that can easily change its particle morphology. It can form outstretched and rolled fibers with plastic or brittle behavior, and cubes. In Na-batteries, metallic Na anodes demonstrate a high reactivity towards the majority of electrolyte solutions, volume change and a random deposition process from the electrolyte, accompanied by dendrite formation. In order to smooth the electrochemical Na deposition, we propose NaOH as a simple artificial protective layer for sodium, formed by its exposure to ambient conditions for a certain period of time. The formed NaOH layer on top of the metallic sodium suppresses the volume change and dendrite growth on the sodium surface. Additionally, the protected sodium does not change its morphology after a prolonged contact with carbonate-based electrolytes. In symmetric Na-batteries, the NaOH layer increases the lifetime of the electrochemical cell by eight times in comparison to non-protected Na. In the full-cell with a layered sodium oxide cathode, the NaOH-protected sodium anode also leads to a high cycling stability, providing 81 % of the initial cell capacity after 500 cycles with a 1C current rate. In contrast, batteries with a non-protected Na-anode reach only 20 % of their initial capacity under the same conditions. Therefore, the main benefits of the NaOH artificial layer are the chemical compatibility with the carbonate-based electrolytes, the protection of Na metal against reaction with the electrolyte solution, the rapid Na-ion diffusion through the layer and the formation of a mechanical barrier, mitigating Na-dendrite growth. This work presents an easily scalable method to protect sodium without any additional chemicals or a special environment for this reaction

Acid Treatments of Ti-Based Metallic Glasses for Improving Corrosion Resistance in Implant Applications

Ti-based bulk metallic glasses are promising materials for metallic bone implants, mainly due to their mechanical biofunctionality. A major drawback is their limited corrosion resistance, with high sensitivity to pitting. Thus, effective surface treatments for these alloys must be developed. This work investigates the electrochemical treatment feasibility of nitric acid (HNO3) solution for two bulk glass-forming alloys. The surface states obtained at different anodic potentials are characterized with electron microscopy and Auger electron spectroscopy. The corrosion behavior of the treated glassy alloys is analyzed via comparison to non-treated states in phosphate-buffered saline solution (PBS) at 37 °C. For the glassy Ti47Zr7.5Cu38Fe2.5Sn2Si1Ag2 alloy, the pre-treatment causes pseudo-dealloying, with a transformation from naturally passivated surfaces to Ti- and Zr-oxide nanoporous layers and Cu-species removal from the near-surface regions. This results in effective suppression of chloride-induced pitting in PBS. The glassy Ti40Zr10Cu34Pd14Sn2 alloy shows lower free corrosion activity in HNO3 and PBS due to Pd stabilizing its strong passivity. However, this alloy undergoes pitting under anodic conditions. Surface pre-treatment results in Cu depletion but causes enrichment of Pd species and non-homogeneous surface oxidation. Therefore, for this glassy alloy, pitting cannot be completely inhibited in PBS. Concluding, anodic treatments in HNO3 are more suitable for Pd-free glassy Ti-based alloys

Sp1/Sp3 and DNA-methylation contribute to basal transcriptional activation of human podoplanin in MG63 versus Saos-2 osteoblastic cells

BACKGROUND: Podoplanin is a membrane mucin that, among a series of tissues, is expressed on late osteoblasts and osteocytes. Since recent findings have focussed on podoplanin's potential role as a tumour progression factor, we aimed at identifying regulatory elements conferring PDPN promoter activity. Here, we characterized the molecular mechanism controlling basal PDPN transcription in human osteoblast-like MG63 versus Saos-2 cells. RESULTS: We cloned and sequenced 2056 nucleotides from the 5'-flanking region of the PDPN gene and a computational search revealed that the TATA and CAAT box-lacking promoter possesses features of a growth-related gene, such as a GC-rich 5' region and the presence of multiple putative Sp1, AP-4 and NF-1 sites. Reporter gene assays demonstrated a functional promoter in MG63 cells exhibiting 30-fold more activity than in Saos-2 cells. In vitro DNase I footprinting revealed eight protected regions flanked by DNaseI hypersensitive sites within the region bp -728 to -39 present in MG63, but not in Saos-2 cells. Among these regions, mutation and supershift electrophoretic mobility shift assays (EMSA) identified four Sp1/Sp3 binding sites and two binding sites for yet unknown transcription factors. Deletion studies demonstrated the functional importance of two Sp1/Sp3 sites for PDPN promoter activity. Overexpression of Sp1 and Sp3 independently increased the stimulatory effect of the promoter and podoplanin mRNA levels in MG63 and Saos-2 cells. In SL2 cells, Sp3 functioned as a repressor, while Sp1 and Sp3 acted positively synergistic. Weak PDPN promoter activity of Saos-2 cells correlated with low Sp1/Sp3 nuclear levels, which was confirmed by Sp1/Sp3 chromatin immunoprecipitations in vivo. Moreover, methylation-sensitive Southern blot analyses and bisulfite sequencing detected strong methylation of CpG sites upstream of bp -464 in MG63 cells, but hypomethylation of these sites in Saos-2 cells. Concomitantly, treatment with the DNA methyltransferase inhibitor 5-azaCdR in combination with trichostatin A (TSA) downregulated podoplanin mRNA levels in MG63 cells, and region-specific in vitro methylation of the distal promoter suggested that DNA methylation rather enhanced than hindered PDPN transcription in both cell types. CONCLUSION: These data establish that in human osteoblast-like MG63 cells, Sp1 and Sp3 stimulate basal PDPN transcription in a concerted, yet independent manner, whereas Saos-2 cells lack sufficient nuclear Sp protein amounts for transcriptional activation. Moreover, a highly methylated chromatin conformation of the distal promoter region confers cell-type specific podoplanin upregulation versus Saos-2 cells

Targeting Androgen, Thyroid Hormone, and Vitamin A and D Receptors to Treat Prostate Cancer

The nuclear hormone family of receptors regulates gene expression. The androgen receptor (AR), upon ligand binding and homodimerization, shuttles from the cytosol into the nucleus to activate gene expression. Thyroid hormone receptors (TRs), retinoic acid receptors (RARs), and the vitamin D receptor (VDR) are present in the nucleus bound to chromatin as a heterodimer with the retinoid X receptors (RXRs) and repress gene expression. Ligand binding leads to transcription activation. The hormonal ligands for these receptors play crucial roles to ensure the proper conduct of very many tissues and exert effects on prostate cancer (PCa) cells. Androgens support PCa proliferation and androgen deprivation alone or with chemotherapy is the standard therapy for PCa. RARγ activation and 3,5,3′-triiodo-L-thyronine (T3) stimulation of TRβ support the growth of PCa cells. Ligand stimulation of VDR drives growth arrest, differentiation, and apoptosis of PCa cells. Often these receptors are explored as separate avenues to find treatments for PCa and other cancers. However, there is accumulating evidence to support receptor interactions and crosstalk of regulatory events whereby a better understanding might lead to new combinatorial treatments

Water-Free SbOx ALD Process for Coating Bi2Te3 Particle

We developed a water-free atomic layer deposition (ALD) process to homogeneously deposit SbOx using SbCl5 and Sb-Ethoxide as precursors, and report it here for the first time. The coating is applied on Bi2Te3 particles synthesized via the solvothermal route to enhance the thermoelectric properties (i.e., Seebeck coefficient, thermal and electrical conductivity) via interface engineering. The amorphous character of the coating was shown by the missing reflexes on the X-ray diffractograms (XRD). A shift from the oxidation state +III to +V of the Sb species was observed using X-ray photoelectron spectroscopy (XPS), indicating increased thickness of the SbOx coating layer. Additionally, a peak shift of the Sb 3d5/2 + O 1s peak indicated increased n-type doping of the material. Electrical measurements of spark plasma-sintered bulk samples confirmed the doping effect on the basis of decreased specific resistivity with increasing SbOx layer thickness. The Seebeck coefficient was improved for the coated sample with 500 cycles of SbOx, while the total thermal conductivity was reduced, resulting in enhancement of the zT. The results distinctly show that surface engineering via powder ALD is an effective tool for improving key properties of thermoelectric materials like electrical conductivity and the Seebeck coefficient