9,894 research outputs found
3D polarization speckle as a demonstration of tensor version of the van Cittert-Zernike theorem for stochastic electromagnetic beams
New insights on Drosophila antimicrobial peptide function in host defense and beyond
This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record Since the first animal antimicrobial peptides (AMPs) were discovered in insects, Drosophila melanogaster has emerged as a powerful model for their characterization. Drosophila AMPs have been used extensively to monitor the activity of the Toll and Imd NF-κB pathways, but little was known of their precise functions. In this review, we summarize recent findings on the function of Drosophila AMPs not only for antimicrobial defense, but also in the gut, tumor control, and neurology. The integration of these new studies allows a new framework to be drawn that explains how AMPs can contribute simultaneously to microbe killing whilst also regulating important host cellular functions. These functions require that AMPs target not only negatively charged microbes but also aberrant host cells.SNF SinergiaNovarti
Three‐dimensional, multispecies, high spatial resolution MHD studies of the solar wind interaction with Mars
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95232/1/jgra17355.pd
Ecology-relevant bacteria drive the evolution of host antimicrobial peptides in Drosophila
This is the author accepted manuscript. The final version is available from the American Association for the Advancement of Science via the DOI in this recordData availability: Raw data and analysis scripts and outputs are available in the supplementary data files included with this manuscriptAntimicrobial peptides are host-encoded immune effectors that combat pathogens and shape the microbiome in plants and animals. However, little is known about how the host antimicrobial peptide repertoire is adapted to its microbiome. Here, we characterized the function and evolution of the Diptericin antimicrobial peptide family of Diptera. Using mutations affecting the two Diptericins (Dpt) of Drosophila melanogaster, we reveal the specific role of DptA for the pathogen Providencia rettgeri and DptB for the gut mutualist Acetobacter. The presence of DptA- or DptB-like genes across Diptera correlates with the presence of Providencia and Acetobacter in their environment. Moreover, DptA- and DptB-like sequences predict host resistance against infection by these bacteria across the genus Drosophila. Our study explains the evolutionary logic behind the bursts of rapid evolution of an antimicrobial peptide family and reveals how the host immune repertoire adapts to changing microbial environments.Swiss National Science Foundation (SNSF)SinergiaNovartis Foundatio
Coherence and polarization speckle generated by a rough-surfaced retardation plate depolarizer.
An Ultra-High Discrimination Y Chromosome Short Tandem Repeat Multiplex DNA Typing System
In forensic casework, Y chromosome short tandem repeat markers (Y-STRs) are often used to identify a male donor DNA profile in the presence of excess quantities of female DNA, such as is found in many sexual assault investigations. Commercially available Y-STR multiplexes incorporating 12–17 loci are currently used in forensic casework (Promega's PowerPlex® Y and Applied Biosystems' AmpFlSTR® Yfiler®). Despite the robustness of these commercial multiplex Y-STR systems and the ability to discriminate two male individuals in most cases, the coincidence match probabilities between unrelated males are modest compared with the standard set of autosomal STR markers. Hence there is still a need to develop new multiplex systems to supplement these for those cases where additional discriminatory power is desired or where there is a coincidental Y-STR match between potential male participants. Over 400 Y-STR loci have been identified on the Y chromosome. While these have the potential to increase the discrimination potential afforded by the commercially available kits, many have not been well characterized. In the present work, 91 loci were tested for their relative ability to increase the discrimination potential of the commonly used ‘core’ Y-STR loci. The result of this extensive evaluation was the development of an ultra high discrimination (UHD) multiplex DNA typing system that allows for the robust co-amplification of 14 non-core Y-STR loci. Population studies with a mixed African American and American Caucasian sample set (n = 572) indicated that the overall discriminatory potential of the UHD multiplex was superior to all commercial kits tested. The combined use of the UHD multiplex and the Applied Biosystems' AmpFlSTR® Yfiler® kit resulted in 100% discrimination of all individuals within the sample set, which presages its potential to maximally augment currently available forensic casework markers. It could also find applications in human evolutionary genetics and genetic genealogy
Demonstration of entanglement-by-measurement of solid state qubits
Projective measurements are a powerful tool for manipulating quantum states.
In particular, a set of qubits can be entangled by measurement of a joint
property such as qubit parity. These joint measurements do not require a direct
interaction between qubits and therefore provide a unique resource for quantum
information processing with well-isolated qubits. Numerous schemes for
entanglement-by-measurement of solid-state qubits have been proposed, but the
demanding experimental requirements have so far hindered implementations. Here
we realize a two-qubit parity measurement on nuclear spins in diamond by
exploiting the electron spin of a nitrogen-vacancy center as readout ancilla.
The measurement enables us to project the initially uncorrelated nuclear spins
into maximally entangled states. By combining this entanglement with
high-fidelity single-shot readout we demonstrate the first violation of Bells
inequality with solid-state spins. These results open the door to a new class
of experiments in which projective measurements are used to create, protect and
manipulate entanglement between solid-state qubits.Comment: 6 pages, 4 figure
Decoherence-protected quantum gates for a hybrid solid-state spin register
Protecting the dynamics of coupled quantum systems from decoherence by the
environment is a key challenge for solid-state quantum information processing.
An idle qubit can be efficiently insulated from the outside world via dynamical
decoupling, as has recently been demonstrated for individual solid-state
qubits. However, protection of qubit coherence during a multi-qubit gate poses
a non-trivial problem: in general the decoupling disrupts the inter-qubit
dynamics, and hence conflicts with gate operation. This problem is particularly
salient for hybrid systems, wherein different types of qubits evolve and
decohere at vastly different rates. Here we present the integration of
dynamical decoupling into quantum gates for a paradigmatic hybrid system, the
electron-nuclear spin register. Our design harnesses the internal resonance in
the coupled-spin system to resolve the conflict between gate operation and
decoupling. We experimentally demonstrate these gates on a two-qubit register
in diamond operating at room temperature. Quantum tomography reveals that the
qubits involved in the gate operation are protected as accurately as idle
qubits. We further illustrate the power of our design by executing Grover's
quantum search algorithm, achieving fidelities above 90% even though the
execution time exceeds the electron spin dephasing time by two orders of
magnitude. Our results directly enable decoherence-protected interface gates
between different types of promising solid-state qubits. Ultimately, quantum
gates with integrated decoupling may enable reaching the accuracy threshold for
fault-tolerant quantum information processing with solid-state devices.Comment: This is original submitted version of the paper. The revised and
finalized version is in print, and is subjected to the embargo and other
editorial restrictions of the Nature journa
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