Point-Source Power in 3 Year Wilkinson Microwave Anisotropy Probe Data

Using a set of multifrequency cross spectra computed from the 3 year WMAP sky maps, we fit for the unresolved point-source contribution. For a white-noise power spectrum, we find a Q-band amplitude of A = 0.011 ± 0.001 μK^2 sr (antenna temperature), significantly smaller than the value of 0.017 ± 0.002 μK^2 sr used to correct the spectra in the WMAP release. Modifying the point-source correction in this way largely resolves the discrepancy that Eriksen et al. found between the WMAP V- and W-band power spectra. Correcting the co-added WMAP spectrum for both the low-l power excess due to a suboptimal likelihood approximation—also reported by Eriksen et al.—and the high-l power deficit due to oversubtracted point sources—presented in this Letter—we find that the net effect in terms of cosmological parameters is an ~0.7 σ shift in n_s to larger values. For the combination of WMAP, BOOMERANG, and ACBAR data, we find ns = 0.969 ± 0.016, lowering the significance of n_s ≠ 1 from ~2.7 σ to ~2.0 σ

Deep Convolutional Neural Networks for Interpretable Analysis of EEG Sleep Stage Scoring

Sleep studies are important for diagnosing sleep disorders such as insomnia, narcolepsy or sleep apnea. They rely on manual scoring of sleep stages from raw polisomnography signals, which is a tedious visual task requiring the workload of highly trained professionals. Consequently, research efforts to purse for an automatic stage scoring based on machine learning techniques have been carried out over the last years. In this work, we resort to multitaper spectral analysis to create visually interpretable images of sleep patterns from EEG signals as inputs to a deep convolutional network trained to solve visual recognition tasks. As a working example of transfer learning, a system able to accurately classify sleep stages in new unseen patients is presented. Evaluations in a widely-used publicly available dataset favourably compare to state-of-the-art results, while providing a framework for visual interpretation of outcomes.Comment: 8 pages, 1 figure, 2 tables, IEEE 2017 International Workshop on Machine Learning for Signal Processin

Predicting spring barley yield from variety-specific yield potential, disease resistance and straw length, and from environment-specific disease loads and weed pressure

Abstract For low-input crop production, well-characterised varieties increase the possibilities of managing diseases and weeds. This analysis aims at developing a framework for analyzing grain yield using external varietal information about disease resistance, weed competitiveness and yield potential and quantifying the impact of susceptibility grouping and straw length scores (as a measure for weed competitiveness) for predicting spring barley grain yield under variable biotic stress levels. The study comprised 52 spring barley varieties and 17 environments, i.e., combinations of location, growing system and year. Individual varieties and their interactions with environments were analysed by factorial regression of grain yield on external variety information combined with observed environmental disease loads and weed pressure. The external information was based on the official Danish VCU testing. The most parsimonious models explained about 50% of the yield variation among varieties including genotypeenvironment interactions. Disease resistance characteristics of varieties, weighted with disease loads of powdery mildew, leaf rust and net blotch, respectively, had a highly significant influence on grain yield. The extend to which increased susceptibility resulted in increased yield losses in environments with high disease loads of the respective diseases was predicted. The effect of externally determined straw length scores, weighted with weed pressure, was weaker although significant for weeds with creeping growth habit. Higher grain yield was thus predicted for taller plants under weed pressure. The results are discussed in relation to the model ramework, impact of the considered traits and use of information from conventional variety testing in organic cropping systems

Asymmetries in the CMB anisotropy field

We report on the results from two independent but complementary statistical analyses of the WMAP first-year data, based on the power spectrum and N-point correlation functions. We focus on large and intermediate scales (larger than about 3 degrees) and compare the observed data against Monte Carlo ensembles with WMAP-like properties. In both analyses, we measure the amplitudes of the large-scale fluctuations on opposing hemispheres and study the ratio of the two amplitudes. The power-spectrum analysis shows that this ratio for WMAP, as measured along the axis of maximum asymmetry, is high at the 95%-99% level (depending on the particular multipole range included). The axis of maximum asymmetry of the WMAP data is weakly dependent on the multipole range under consideration but tends to lie close to the ecliptic axis. In the N-point correlation function analysis we focus on the northern and southern hemispheres defined in ecliptic coordinates, and we find that the ratio of the large-scale fluctuation amplitudes is high at the 98%-99% level. Furthermore, the results are stable with respect to choice of Galactic cut and also with respect to frequency band. A similar asymmetry is found in the COBE-DMR map, and the axis of maximum asymmetry is close to the one found in the WMAP data.Comment: 6 pages, 5 figures; version to appear in ApJ, textual improvements, added reference

Experimental Comparisons of Derivative Free Optimization Algorithms

In this paper, the performances of the quasi-Newton BFGS algorithm, the NEWUOA derivative free optimizer, the Covariance Matrix Adaptation Evolution Strategy (CMA-ES), the Differential Evolution (DE) algorithm and Particle Swarm Optimizers (PSO) are compared experimentally on benchmark functions reflecting important challenges encountered in real-world optimization problems. Dependence of the performances in the conditioning of the problem and rotational invariance of the algorithms are in particular investigated.Comment: 8th International Symposium on Experimental Algorithms, Dortmund : Germany (2009

Increasing evidence for hemispherical power asymmetry in the five-year WMAP data

(Abridged)Motivated by the recent results of Hansen et al. (2008) concerning a noticeable hemispherical power asymmetry in the WMAP data on small angular scales, we revisit the dipole modulated signal model introduced by Gordon et al. (2005). This model assumes that the true CMB signal consists of a Gaussian isotropic random field modulated by a dipole, and is characterized by an overall modulation amplitude, A, and a preferred direction, p. Previous analyses of this model has been restricted to very low resolution due to computational cost. In this paper, we double the angular resolution, and compute the full corresponding posterior distribution for the 5-year WMAP data. The results from our analysis are the following: The best-fit modulation amplitude for l <= 64 and the ILC data with the WMAP KQ85 sky cut is A=0.072 +/- 0.022, non-zero at 3.3sigma, and the preferred direction points toward Galactic coordinates (l,b) = (224 degree, -22 degree) +/- 24 degree. The corresponding results for l <~ 40 from earlier analyses was A = 0.11 +/- 0.04 and (l,b) = (225 degree,-27 degree). The statistical significance of a non-zero amplitude thus increases from 2.8sigma to 3.3sigma when increasing l_max from 40 to 64, and all results are consistent to within 1sigma. Similarly, the Bayesian log-evidence difference with respect to the isotropic model increases from Delta ln E = 1.8 to Delta ln E = 2.6, ranking as "strong evidence" on the Jeffreys' scale. The raw best-fit log-likelihood difference increases from Delta ln L = 6.1 to Delta ln L = 7.3. Similar, and often slightly stronger, results are found for other data combinations. Thus, we find that the evidence for a dipole power distribution in the WMAP data increases with l in the 5-year WMAP data set, in agreement with the reports of Hansen et al. (2008).Comment: 6 pages, 2 figures; added references and minor comments. Accepted for publication in Ap

The scalar perturbation spectral index n_s: WMAP sensitivity to unresolved point sources

Precision measurement of the scalar perturbation spectral index, n_s, from the Wilkinson Microwave Anisotropy Probe temperature angular power spectrum requires the subtraction of unresolved point source power. Here we reconsider this issue. First, we note a peculiarity in the WMAP temperature likelihood's response to the source correction: Cosmological parameters do not respond to increased source errors. An alternative and more direct method for treating this error term acts more sensibly, and also shifts n_s by ~0.3 sigma closer to unity. Second, we re-examine the source fit used to correct the power spectrum. This fit depends strongly on the galactic cut and the weighting of the map, indicating that either the source population or masking procedure is not isotropic. Jackknife tests appear inconsistent, causing us to assign large uncertainties to account for possible systematics. Third, we note that the WMAP team's spectrum was computed with two different weighting schemes: uniform weights transition to inverse noise variance weights at l = 500. The fit depends on such weighting schemes, so different corrections apply to each multipole range. For the Kp2 mask used in cosmological analysis, we prefer source corrections A = 0.012 +/- 0.005 muK^2 for uniform weighting and A = 0.015 +/- 0.005 muK^2 for N_obs weighting. Correcting WMAP's spectrum correspondingly, we compute cosmological parameters with our alternative likelihood, finding n_s = 0.970 +/- 0.017 and sigma_8 = 0.778 +/- 0.045 . This n_s is only 1.8 sigma from unity, compared to the ~2.6 sigma WMAP 3-year result. Finally, an anomalous feature in the source spectrum at l<200 remains, most strongly associated with W-band.Comment: 9 pages, 10 figures, 3 tables. Submitted to Ap

Alloreactive cytotoxic T lymphocytes generated in the presence of viral- derived peptides show exquisite peptide and MHC specificity

The nature of alloreactivity to MHC molecules has been enigmatic, primarily because of the observation that allogeneic responses are considerably stronger than syngeneic responses. To better determine the specificity potential of allogeneic responses, we have generated alloreactive CTL specific for exogenous, viral-derived peptide ligands. This approach allowed us to critically evaluate both the peptide- and MHC-specificity of these alloreactive T cells. Exploiting the accessibility of the H-2Ld class I molecule for exogenous peptide ligands, alloreactive CTL were generated that are specific for either murine cytomegalovirus (MCMV) or lymphocytic choriomeningitis virus (LCMV) peptides bound by Ld alloantigens. Peptide specificity was initially observed in bulk cultures of alloreactive CTL only when tested on peptide-sensitized T2.Ld target cells that have defective presentation of endogenous peptides. Subsequent cloning of bulk alloreactive CTL lines generated to MCMV yielded CTL clones that had exquisitely specific MCMV peptide recognition requirement. All of the MCMV/Ld alloreactive CTL clones were also exquisitely MHC-specific in that none of the CTL clones lysed targets expressing MCMV/Lq complexes, even though Lq differs from Ld by only six amino acid residues and Lq also binds the MCMV peptide. This observation clearly demonstrates that alloreactive CTL are capable of the same degree of specificity for target cell recognition as are syngeneic CTL in MHC-restricted responses

Evidence of vorticity and shear at large angular scales in the WMAP data: a violation of cosmological isotropy?

Motivated by the large-scale asymmetry observed in the cosmic microwave background sky, we consider a specific class of anisotropic cosmological models -- Bianchi type VII_h -- and compare them to the WMAP first-year data on large angular scales. Remarkably, we find evidence of a correlation which is ruled out as a chance alignment at the 3sigma level. The best fit Bianchi model corresponds to x=0.55, Omega_0=0.5, a rotation axis in the direction (l,b)=(222degr,-62degr), shear (sigma/H)_0=2.4e-10 and a right--handed vorticity (omega/H)_0=6.1e-10. Correcting for this component greatly reduces the significance of the large-scale power asymmetry, resolves several anomalies detected on large angular scales (ie. the low quadrupole amplitude and quadrupole/octopole planarity and alignment), and can account for a non--Gaussian "cold spot" on the sky. Despite the apparent inconsistency with the best-fit parameters required in inflationary models to account for the acoustic peaks, we consider the results sufficiently provocative to merit further consideration.Comment: 4 pages, 3 figures; emulateapj.cls; ApJL accepted version plus fixed error in vorticity calculation (sqrt(2) off in Table 1, abstract, and conclusions); basic conclusions unchange