Tunable BODIPY derivatives amenable to "click" and peptide chemistry

Novel azido- and amino- functionalised fluorescent probes based on the BODIPY framework have been developed. The probes can be easily and cheaply synthesised, exhibit the highly desirable BODIPY fluorescent properties, and are amenable to “click” and peptide chemistry methodologies. These probes provide a stable and readily available tool amenable for the visualisation of both solution and solid supported events

Bounds on the cosmological abundance of primordial black holes from diffuse sky brightness: single mass spectra

We constrain the mass abundance of unclustered primordial black holes (PBHs), formed with a simple mass distribution and subject to the Hawking evaporation and particle absorption from the environment. Since the radiative flux is proportional to the numerical density, an upper bound is obtained by comparing the calculated and observed diffuse background values, (similarly to the Olbers paradox in which point sources are considered) for finite bandwidths. For a significative range of formation redshifts the bounds are better than several values obtained by other arguments $\Omega_{pbh} \leq 10^{-10}$; and they apply to PBHs which are evaporating today.Comment: 20 pages, 5 figures, to appear in PR

Uncorrelated scattering approximation revisited

The formalism to describe the scattering of a weakly bound projectile nucleus by a heavy target is investigated, using the Uncorrelated Scattering Approximation. The main assumption involved is to neglect the correlation between the fragments of the projectile in the region where the interaction with the target is important. It is shown that the angular momentum of each fragment with respect to the target is conserved. Moreover, when suitable approximations are assumed, the kinetic energy of each fragment is also shown to be conserved. The S-matrix for the scattering of the composite system can be written as a combination of terms, each one being proportional to the product of the S-matrices of the fragments.Comment: 27 pages, 6 figures, submitted to Nucl. Phys. A (v2: minor misprints and grammatical errors corrected

Long range absorption in the scattering of 6He on 208Pb and 197Au at 27 MeV

Quasi-elastic scattering of 6He at E_lab=27 MeV from 197Au has been measured in the angular range of 6-72 degrees in the laboratory system employing LEDA and LAMP detection systems. These data, along with previously analysed data of 6He + 208Pb at the same energy, are analyzed using Optical Model calculations. The role of Coulomb dipole polarizability has been investigated. Large imaginary diffuseness parameters are required to fit the data. This result is an evidence for long range absorption mechanisms in 6He induced reactions.Comment: 10 pages, 10 figures, minor corrections. To appear in Nucl. Phys.

Life cycle modelling of environmental impacts of application of processed organic municipal solid waste on agricultural land (EASEWASTE)

A model capable of quantifying the potential environmental impacts of agricultural application of composted or anaerobically digested source-separated organic municipal solid waste (MSW) is presented. In addition to the direct impacts, the model accounts for savings by avoiding the production and use of commercial fertilizers. The model is part of a larger model, Environmental Assessment of Solid Waste Systems and Technology (EASEWASTE), developed as a decisionsupport model, focusing on assessment of alternative waste management options. The environmental impacts of the land application of processed organic waste are quantified by emission coefficients referring to the composition of the processed waste and related to specific crop rotation as well as soil type. The model contains several default parameters based on literature data, field experiments and modelling by the agro-ecosystem model, Daisy. All data can be modified by the user allowing application of the model to other situations. A case study including four scenarios was performed to illustrate the use of the model. One tonne of nitrogen in composted and anaerobically digested MSW was applied as fertilizer to loamy and sandy soil at a plant farm in western Denmark. Application of the processed organic waste mainly affected the environmental impact categories global warming (0.4–0.7 PE), acidification (–0.06 (saving)–1.6 PE), nutrient enrichment (–1.0 (saving)–3.1 PE), and toxicity. The main contributors to these categories were nitrous oxide formation (global warming), ammonia volatilization (acidification and nutrient enrichment), nitrate losses (nutrient enrichment and groundwater contamination), and heavy metal input to soil (toxicity potentials). The local agricultural conditions as well as the composition of the processed MSW showed large influence on the environmental impacts. A range of benefits, mainly related to improved soil quality from long-term application of the processed organic waste, could not be generally quantified with respect to the chosen life cycle assessment impact categories and were therefore not included in the model. These effects should be considered in conjunction with the results of the life cycle assessment

Quasiconvex Constrained Multicriteria Continuous Location Problems: Structure of Nondominated Solution Sets

In this paper, we consider constrained multicriteria continuous location problems in two-dimensional spaces. In the literature, the continuous multicriteria location problem in two-dimensional spaces has received special attention in the last years, although only particular instances of convex functions have been considered. Our approach only requires the functions to be strictly quasiconvex and inf-compact. We obtain a geometrical description that provides a unified approach to handle multicriteria location models in two-dimensional spaces which has been implemented in MATHEMATIC

How participatory design works:mechanisms and effects

We argue that the distinguishing features of Participatory Design are not the participatory activities as such but the mechanisms used, the effects produced and the way in which these are sustained. We use program theory to illuminate how participatory design works and how it may be understood as more than a collection of methods or a matter of configuring user participation. Program theory operates by formulating the causal relations between the planned inputs, the process and the effects in terms of output, outcome and impact. While participatory design might appear similar to co-design or user-centered design on the level of design activities, PD differs in terms of the mechanisms employed and how effects and their sustainment are conceived. Looking at participatory design through the lens of program theory highlights how particular mechanisms work towards not only the designed product but also towards generating gains and lasting effects for participants