Which climate services do farmers and pastoralists need in Malawi?

This report presents final findings from the baseline data collection exercise conducted for the Global Framework for Climate Services (GFCS) Adaptation Programme in Africa. The GFCS programme seeks to improve climate services for agriculture, food security, heath and disaster risk reduction in Tanzania and Malawi. Under the auspices of this GFCS project, the CGIAR research program on Climate Change, Agriculture and Food Security (CCAFS) is responsible to support baseline data collection and monitoring and evaluation to evaluate climate services for farmers and pastoralists in both countries. The purpose of this report is to inform national partners on farmers’ current needs and access to climate information services. Households interviewed in Malawi are mostly crop farmers, and have access to conventional climate information. However, they rely more on indigenous knowledge, personal experience and traditional cropping calendar than on climate information for their farm decision-making. Respondents would like to receive more advice about improved cropping practices, and better communication of climate information through village meetings and in their local languages. The climate information farmers would like to receive includes forecasts of extreme events, onset of the rains, seasonal rainfall, daily weather, and pest and diseases. These forecasts should be timely. Seasonal forecasts should be available preferably months before the start of the season to allow farmers to integrate them in their farm management decisions. The preferred communication channels were visits from extension agents, radio messages and SMS in cell phones. Farmers trust information from government extension agents, radio presenters and NGOs. Women particularly trust NGO workers

What climate services do farmers and pastoralists need in Tanzania?

This report presents final findings from the baseline data collection exercise conducted for Global Framework for Climate Services (GFCS) Adaptation Programme in Africa. The GFCS programme, having a focus on agriculture, food security, heath and disaster risk reduction, is implemented in Tanzania and Malawi. Under the auspices of this GFCS project, the CGIAR research program on Climate Change, Agriculture and Food Security (CCAFS) is responsible to support baseline data collection and monitoring and evaluation (M&E) to evaluate climate services for farmers and pastoralists in Tanzania. The purpose of this report is to inform national partners on farmers’ current access and needs for climate information services. Communities of agro-pastoralists and pastoralists interviewed have little access to climate information, which is generally not associated with agricultural advice. To increase the relevance and communication of climate information in their communities, respondents have recommended training of local extension agents and traditional leaders on the concepts of climate information, having site specific information and using local languages and brochures. The forecasts of greatest interest include start of the rain and expected amount of rainfall over the season. Preferred formats cited by men are radio messages, visits from extension agents while women selected voice message on cell phones and villages communicators. Messengers suggested for radio presenters, local extension agents and village leaders highly recommended by women

Climate services for agriculture in Rwanda: What farmers know about climate information services in Rwanda

We evaluated 3,046 farmers spread across the country’s districts to establish baseline about climate information and climate change, in September 2016. This Info Note shares insights into the status and needs for climate services in Rwanda at the time of this survey

International portfolio flows and exchange rate volatility in emerging Asian markets

This paper investigates the effects of equity and bond portfolio inflows on exchange rate volatility using monthly bilateral data for the US vis-a-vis seven Asian developing and emerging countries (India, Indonesia, Pakistan, the Philippines, South Korea, Taiwan and Thailand) over the period 1993:01-2015:11. GARCH models and Markov switching specifications with time-varying transition probabilities are estimated in addition to a benchmark linear model. The evidence suggests that high (low) exchange rate volatility is associated with equity (bond) inflows from the Asian countries toward the US in all cases, with the exception of the Philippines. Therefore, capital controls could be an effective tool to stabilise the foreign exchange market in countries where flows affect exchange rate volatility

De Novo Mutations in SIK1 Cause a Spectrum of Developmental Epilepsies

Developmental epilepsies are age-dependent seizure disorders for which genetic causes have been increasingly identified. Here we report six unrelated individuals with mutations in salt-inducible kinase 1 (SIK1) in a series of 101 persons with early myoclonic encephalopathy, Ohtahara syndrome, and infantile spasms. Individuals with SIK1 mutations had short survival in cases with neonatal epilepsy onset, and an autism plus developmental syndrome after infantile spasms in others. All six mutations occurred outside the kinase domain of SIK1 and each of the mutants displayed autophosphorylation and kinase activity toward HDAC5. Three mutations generated truncated forms of SIK1 that were resistant to degradation and also showed changes in sub-cellular localization compared to wild-type SIK1. We also report the human neuropathologic examination of SIK1-related developmental epilepsy, with normal neuronal morphology and lamination but abnormal SIK1 protein cellular localization. Therefore, these results expand the genetic etiologies of developmental epilepsies by demonstrating SIK1 mutations as a cause of severe developmental epilepsy

The Vehicle, Fall 1978

Vol. 2, No. 1 Table of Contents FarewellGregory Manifoldpage 4 Visiting HoursCindy Grocepage 5 The Deer KillerG.L. Bullardpage 6 Identity CrisisCindy Grocepage 9 I ScreamDale Stroheckerpage 11 John RobertLee Martinpage 12 Smiling in WinterNancy Cunninghampage 20 Walt Disney Told Us LiesThomas C. Howellpage 20 LakesideMary McDanielpage 21 Heavy LiteratureTerry Kroenungpage 22 Old FriendsMary McDanielpage 27 A Sunny AfternoonJoan O\u27Connorpage 28 Always TomorrowMary McDanielpage 29 Four SunsetsGregory Manifoldpage 30 Come FreeBob Welshpage 32 Faded PinstripesLee Martinpage 33 WindsongCarolyn Perrypage 38 SilenceSylvia Aldertonpage 39 One More TimeCheri Clousepage 40 Grandfather Was IlliterateCindy Grocepage 41 StonehengeGregory Manifoldpage 43 GabsCheri Clousepage 44 Spindley Bare BranchesJeanne Hansenpage 48 Art CoverLafayette Wilson PhotographBill Cochranpage 3 DrawingLafayette Wilsonpage 10 DrawingLafayette Wilsonpage 19 PhotographBill Cochranpage 21 PhotographBarbara Colemanpage 28 DrawingJoyce Bonwellpage 31 PhotographKathy Sanderspage 39 DrawingKathy Sanderspage 42https://thekeep.eiu.edu/vehicle/1035/thumbnail.jp

PRMT1 promotes neuroblastoma cell survival through ATF5

Aberrant expression of protein arginine methyltransferases (PRMTs) has been implicated in a number of cancers, making PRMTs potential therapeutic targets. But it remains not well understood how PRMTs impact specific oncogenic pathways. We previously identified PRMTs as important regulators of cell growth in neuroblastoma, a deadly childhood tumor of the sympathetic nervous system. Here, we demonstrate a critical role for PRMT1 in neuroblastoma cell survival. PRMT1 depletion decreased the ability of murine neuroblastoma sphere cells to grow and form spheres, and suppressed proliferation and induced apoptosis of human neuroblastoma cells. Mechanistic studies reveal the prosurvival factor, activating transcription factor 5 (ATF5) as a downstream effector of PRMT1-mediated survival signaling. Furthermore, a diamidine class of PRMT1 inhibitors exhibited anti-neuroblastoma efficacy both in vitro and in vivo. Importantly, overexpression of ATF5 rescued cell apoptosis triggered by PRMT1 inhibition genetically or pharmacologically. Taken together, our findings shed new insights into PRMT1 signaling pathway, and provide evidence for PRMT1 as an actionable therapeutic target in neuroblastoma