On high-altitude and high- latitude frost environments

Frost environments occur throughout the world, with associated processes occurring across climatic zones. Climatic geomorphology proposes that climatic zones, largely derived from annual average air temperature and precipitation values, have specific landforms and processes active within that zone. This study offers unique insights into the frost environments of three locations in the Southern Hemisphere, namely the Eastern Cape Drakensberg of South Africa, sub-Antarctic Marion Island, and Dronning Maud Land of Antarctica. The Drakensberg ranges from temperate to alpine, Marion Island is hyper-maritime, and Dronning Maud Land a polar desert. Drivers and forcings on the ground frost regime are identified, as are future climatic scenarios. Altitude and latitude were identified as the most important locational drivers, while air temperature showed highest correlation with freezing events. The initiation of a freeze event correlated strongly with maximum ground temperatures. Vegetation cover was found to ameliorate frost cycles, thereby increasing ground temperatures. Dronning Maud Land of Antarctica is characterised by annual frost (permafrost), with limited seasonal thaw in summer. Thawing cycles reflected the depth of the active layer, which ranged from just under 60 cm for Robertskollen (at lowest altitude) to less than 15 cm on Slettfjell (at greatest altitude). Marion Island had the most active frost environment, exhibiting both seasonal frost, and ubiquitous shallow diurnal frost cycles. The Drakensberg were largely frost-free, with limited seasonal frost and few diurnal freeze- thaw events. Diurnal frost processes were found to be azonal, and present at all three study locations. Evidence of landforms derived from diurnal frost processes were evident in each zone. Equifinality/convergence of form was present to a degree. The presence of patterned ground, which was not wholly derived from frost processes, suggests a measure of equifinality. Furthermore, openwork block deposits, of which not all are either blockstreams nor blockfields, are not necessarily the result of frost processes. The periglacial environment is poorly defined and methods to delineate this environment, as well as other climatic zones, should include additional parameters. Delineating zones on annual (and limited) monthly averages based on predominantly temperature, is not sufficient. While concepts of climatic geomorphology may be applied in a general sense, this framework is not suited to working at smaller scales. Specifically, periglacial environments should be delineated using ground moisture, as well as air temperature. Furthermore, vegetation and snow cover are important, as are soil textural properties

Geomorphological processes and landforms of glacier forelands in the upper Aktru River basin (Gornyi Altai), Russia : evidence for rapid recent retreat and paraglacial adjustment

The glaciers in the Aktru River basin of Gornyi Altai, Russia currently represent some of the fastest receding glaciers in the world. Formation of the morainic complexes closest to the contemporary glaciers in the Aktru River basin took place during the 17th - 18th centuries with recession commencing at the end of the 18th century. Coupled with this glacial retreat, earth surface processes and vegetation succession are responding to shape the glacier forelands. This article presents the first geomorphological maps for the upper reaches of the Aktru River basin and focuses on the geomorphological landforms that occur in the rapidly changing glacier forelands. Geomorphological mapping is difficult in steep mountainous regions and, thus, mapping was completed using satellite imagery, field mapping and observations coupled with highresolution aerial photography obtained from Unmanned Aerial Vehicles (UAVs). Critical steps of the procedure used to process UAV imagery and difficulties encountered in this mountainous terrain are noted. The acquired spatial data enable the mapping and classification of small-scale transient geomorphological features such as talus, glacial and glaciofluvial landforms. Their dynamics provide insights into supraglacial and subglacial processes of the glaciers of the Aktru River basin and subsequent paraglacial adjustment. The presented highresolution spatial data, which can also be obtained at high temporal resolutions in the future, can act as a reference frame for geomorphologists and ecologists studying the temporal evolution of glacier forelands of the Aktru River basin during paraglacial adjustment and subsequent colonisation and stabilisation by biota.Incentive Funding for Rated Researchers Programme from the National Research Foundation South Africa, the BRICS Network University International Thematic Groups Seed-Funding and the Tomsk State University Competitive Improvement Programme.https://www.springer.com/journal/116292021-04-11hj2020Geography, Geoinformatics and Meteorolog

The connection between the initial and unique solutions of domain equations in the partial order and metric approach

The purpose of this paper is twofold: First, we show in which way the initial solution of a domain equation for cpo’s and the unique solution of a corresponding domain equation for metric spaces are related. Second, we present a technique to lift a given domain equation for cpo’s to a corresponding domain equation for metric spaces

From representing views to representativeness of views: illustrating a new (Q2S) approach in the context of health care priority setting in nine European countries

Governments across Europe are required to make decisions about how best to allocate scarce health care resources. There are legitimate arguments for eliciting societal vales in relation to health care resource allocation given the roles of the general public as payers and potential patients. However, relatively little is known about the views of the general public on general principles which could guide these decisions. In this paper we present five societal viewpoints on principles for health care resources allocation and develop a new approach, Q2S, designed to investigate the extent to which these views are held across a range of European countries. An online survey was developed, based on a previously completed study Q methodology, and delivered between November 2009 and February 2010 across nine countries to 33,515 respondents. The largest proportion of our respondents (44%), were found to most associate themselves with an egalitarian perspective. Differences in views were more strongly associated with countries than with socio-demographic characteristics. These results provide information which could be useful for decision makers in understanding the pluralistic context in which they are making health care resource allocation decisions and how different groups in society may respond to such decisions

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment